Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS von Trowbridge, Jennifer J., Starczynowski, Daniel T.

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Chronic immune response dysregulation in MDS pathogenesis von Barreyro, Laura, Chlon, Timothy M., Starczynowski, Daniel T.

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Are DDX41 variants of unknown significance and pathogenic variants created equal? von Xie, Zhuoer, Starczynowski, Daniel T

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Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs von Muto, Tomoya, Walker, Callum S., Choi, Kwangmin, Hueneman, Kathleen, Smith, Molly A., Gul, Zartash, Garcia-Manero, Guillermo, Ma, Averil, Zheng, Yi, Starczynowski, Daniel T.

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U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies von Smith, Molly A., Choudhary, Gaurav S., Pellagatti, Andrea, Choi, Kwangmin, Bolanos, Lyndsey C., Bhagat, Tushar D., Gordon-Mitchell, Shanisha, Von Ahrens, Dagny, Pradhan, Kith, Steeples, Violetta, Kim, Sanghyun, Steidl, Ulrich, Walter, Matthew, Fraser, Iain D. C., Kulkarni, Aishwarya, Salomonis, Nathan, Komurov, Kakajan, Boultwood, Jacqueline, Verma, Amit, Starczynowski, Daniel T.

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Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia von Chlon, Timothy M., Stepanchick, Emily, Hershberger, Courtney E., Daniels, Noah J., Hueneman, Kathleen M., Kuenzi Davis, Ashley, Choi, Kwangmin, Zheng, Yi, Gurnari, Carmelo, Haferlach, Torsten, Padgett, Richard A., Maciejewski, Jaroslaw P., Starczynowski, Daniel T.

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Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets von Wang, Tiansu, Pine, Allison R., Kotini, Andriana G., Yuan, Han, Zamparo, Lee, Starczynowski, Daniel T., Leslie, Christina, Papapetrou, Eirini P.

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Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome von Rhyasen, Garrett W., Bolanos, Lyndsey, Fang, Jing, Jerez, Andres, Wunderlich, Mark, Rigolino, Carmela, Mathews, Lesley, Ferrer, Marc, Southall, Noel, Guha, Rajarshi, Keller, Jonathan, Thomas, Craig, Beverly, Levi J., Cortelezzi, Agostino, Oliva, Esther N., Cuzzola, Maria, Maciejewski, Jaroslaw P., Mulloy, James C., Starczynowski, Daniel T.

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Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype von Kuchenbauer, Florian, Lam, Wan, Hogge, Donna, Humphries, R Keith, Marra, Marco, Morin, Ryan, Wells, Richard A, Buckstein, Rena, Hirst, Martin, Starczynowski, Daniel T, Sung, Sandy, Muranyi, Andrew, Karsan, Aly, Argiropoulos, Bob

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Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis von Culver-Cochran, Ashley E., Hassan, Aishlin, Hueneman, Kathleen, Choi, Kwangmin, Ma, Averil, VanCauwenbergh, Brett, O’Brien, Eric, Wunderlich, Mark, Perentesis, John P., Starczynowski, Daniel T.

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A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes von Fang, Jing, Liu, Xiaona, Bolanos, Lyndsey, Barker, Brenden, Rigolino, Carmela, Cortelezzi, Agostino, Oliva, Esther N, Cuzzola, Maria, Grimes, H Leighton, Fontanillo, Celia, Komurov, Kakajan, MacBeth, Kyle, Starczynowski, Daniel T

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Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling von Varney, Melinda E, Niederkorn, Madeline, Konno, Hiroyasu, Matsumura, Takayuki, Gohda, Jin, Yoshida, Nobuaki, Akiyama, Taishin, Christie, Susanne, Fang, Jing, Miller, David, Jerez, Andres, Karsan, Aly, Maciejewski, Jaroslaw P, Meetei, Ruhikanta A, Inoue, Jun-ichiro, Starczynowski, Daniel T

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Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation von Muto, Tomoya, Walker, Callum S, Agarwal, Puneet, Vick, Eric, Sampson, Avery, Choi, Kwangmin, Niederkorn, Madeline, Ishikawa, Chiharu, Hueneman, Kathleen, Varney, Melinda, Starczynowski, Daniel T

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Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes von Aoyagi, Yasushige, Hayashi, Yoshihiro, Harada, Yuka, Choi, Kwangmin, Matsunuma, Natsumi, Sadato, Daichi, Maemoto, Yuki, Ito, Akihiro, Yanagi, Shigeru, Starczynowski, Daniel T, Harada, Hironori

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TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling von Agarwal, Puneet, Li, Hui, Choi, Kwangmin, Hueneman, Kathleen, He, Jianbo, Welner, Robert S., Starczynowski, Daniel T., Bhatia, Ravi

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TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis von Niederkorn, Madeline, Hueneman, Kathleen, Choi, Kwangmin, Varney, Melinda E., Romano, Laurel, Pujato, Mario A., Greis, Kenneth D., Inoue, Jun-ichiro, Meetei, Ruhikanta, Starczynowski, Daniel T.

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TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis von Fang, Jing, Muto, Tomoya, Kleppe, Maria, Bolanos, Lyndsey C., Hueneman, Kathleen M., Walker, Callum S., Sampson, Leesa, Wellendorf, Ashley M., Chetal, Kashish, Choi, Kwangmin, Salomonis, Nathan, Choi, Yongwon, Zheng, Yi, Cancelas, Jose A., Levine, Ross L., Starczynowski, Daniel T.

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ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms von Riabov, Vladimir, Xu, Qingyu, Schmitt, Nanni, Streuer, Alexander, Ge, Guo, Bolanos, Lyndsey, Wunderlich, Mark, Jann, Johann-Christoph, Wein, Alina, Altrock, Eva, Demmerle, Marie, Mukherjee, Sanjay, Ali, Abdullah Mahmood, Rapp, Felicitas, Nowak, Verena, Weimer, Nadine, Obländer, Julia, Palme, Iris, Göl, Melda, Jawhar, Ahmed, Darwich, Ali, Wuchter, Patrick, Weiss, Christel, Raza, Azra, Foulks, Jason M, Starczynowski, Daniel T, Yang, Feng-Chun, Metzgeroth, Georgia, Steiner, Laurenz, Jawhar, Mohamad, Hofmann, Wolf-Karsten, Nowak, Daniel

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Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages von Kong, Fansheng, Liu, Zhiwei, Jain, Viral G, Shima, Kenjiro, Suzuki, Takuji, Muglia, Louis J, Starczynowski, Daniel T, Pasare, Chandrashekhar, Bhattacharyya, Sandip

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Myeloid Malignancies with Chromosome 5q Deletions Acquire a Dependency on an Intrachromosomal NF-κB Gene Network von Fang, Jing, Barker, Brenden, Bolanos, Lyndsey, Liu, Xiaona, Jerez, Andres, Makishima, Hideki, Christie, Susanne, Chen, Xiaoting, Rao, Dinesh S., Grimes, H. Leighton, Komurov, Kakajan, Weirauch, Matthew T., Cancelas, Jose A., Maciejewski, Jaroslaw P., Starczynowski, Daniel T.

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