Meeting report from the joint IARC–NCI international cancer seminar series: a focus on colorectal cancer von Gunter, M.J., Alhomoud, S., Arnold, M., Brenner, H., Burn, J., Casey, G., Chan, A.T., Cross, A.J., Giovannucci, E., Hoover, R., Houlston, R., Jenkins, M., Laurent-Puig, P., Peters, U., Ransohoff, D., Riboli, E., Sinha, R., Stadler, Z.K., Brennan, P., Chanock, S.J.

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Comprehensive assessment of germline pathogenic variant detection in tumor-only sequencing von Terraf, P., Pareja, F., Brown, D.N., Ceyhan-Birsoy, O., Misyura, M., Rana, S., O’Reilly, E., Carlo, M.I., Aghajanian, C., Liu, Y., Derakhshan, F., Jayakumaran, G., Weigelt, B., Walsh, M., Stadler, Z., Offit, K., Ladanyi, M., Robson, M., Zehir, A., Reis-Filho, J.S., Mandelker, D.

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Attitudes of patients with metastatic breast cancer toward research biopsies von Seah, D.S., Scott, S.M., Najita, J., Openshaw, T., Krag, K., Frank, E., Sohl, J., Stadler, Z.K., Garrett, M., Silverman, S.G., Peppercorn, J., Winer, E.P., Come, S.E., Lin, Nancy U.

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Changes in the multidisciplinary management of rectal cancer from 2009 to 2015 and associated improvements in short‐term outcomes von Roxburgh, C. S. D., Strombom, P., Lynn, P., Cercek, A., Gonen, M., Smith, J. J., Temple, L. K. F., Nash, G. M., Guillem, J. G., Paty, P. B., Shia, J., Vakiani, E., Yaeger, R., Stadler, Z. K., Segal, N. H., Reidy, D., Varghese, A., Wu, A. J., Crane, C. H., Gollub, M. J., Saltz, L. B., Garcia‐Aguilar, J., Weiser, M. R.

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Mismatch repair deficient rectal cancer is resistant to induction combination chemotherapy von Cercek, A, Dos Santos Fernandes, G, Roxburgh, C, Ng, S, Yaeger, R, Segal, N, Ganesh, K, Reidy, D, Smith, J J, Nash, G, Guillem, J, Paty, P, Shia, J, Garcia-Aguilar, J, Diaz, L, Crane, C, Goodman, K, Saltz, L, Weiser, M, Stadler, Z

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Comparing metastatic (M) young onset (YO) colorectal cancer (CRC) with average onset (AO): Do they differ clinically and genetically? von Dos Santos Fernandes, G., Chatila, W., Yaeger, R., Mendelsohn, R., Stadler, Z., Segal, N.H., Varghese, A., Reidy, D., Diaz, L., Shia, J., Vakiani, E., Hechtman, J., Schultz, N., Berger, M., Hyman, D., Solit, D., Saltz, L., Garcia Aguilar, J., Cercek, A.

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PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer von Cercek, Andrea, Lumish, Melissa, Sinopoli, Jenna, Weiss, Jill, Shia, Jinru, Lamendola-Essel, Michelle, El Dika, Imane H., Segal, Neil, Shcherba, Marina, Sugarman, Ryan, Stadler, Zsofia, Yaeger, Rona, Smith, J. Joshua, Rousseau, Benoit, Argiles, Guillem, Patel, Miteshkumar, Desai, Avni, Saltz, Leonard B., Widmar, Maria, Iyer, Krishna, Zhang, Janie, Gianino, Nicole, Crane, Christopher, Romesser, Paul B., Pappou, Emmanouil P., Paty, Philip, Garcia-Aguilar, Julio, Gonen, Mithat, Gollub, Marc, Weiser, Martin R., Schalper, Kurt A., Diaz, Luis A.

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De novo CDH1 mutation in a family presenting with early-onset diffuse gastric cancer von Shah, MA, Salo-Mullen, E, Stadler, Z, Ruggeri, JM, Mirander, M, Pristyazhnyuk, Y, Zhang, L

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Characterization of Rectal Cancer in Patients With Lynch Syndrome von Ng, S.Y, Shia, J, Cercek, A, Segal, N, Reidy, D, Yaeger, R, Nash, G, Temple, L.K.F, Weiser, M, Kelsen, D, Gaddam, P, Lincoln, A, Markowitz, A, Robson, M, Offit, K, Paty, P, Guillem, J.G, Saltz, L, Goodman, K.A, Stadler, Z

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Cancer risks in women from BRCA -negative hereditary breast and ovarian cancer families von Pike, M, Otegbeye, E, Arnold, A, Stadler, Z, Robson, M, Barakat, R, Offit, K, Chi, D, Kauff, N

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Does postmenopausal risk-reducing salpingo-oophorectomy reduce the risk of BRCA -associated breast cancer? von Pike, M, Otegbeye, E, Arnold, A, Stadler, Z, Robson, M, Aghajanian, C, Offit, K, Barakat, R, Kauff, N

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Discriminatory accuracy and potential clinical utility of genomic profiling for breast cancer risk in BRCA-negative women von Comen, E., Balistreri, L., Gönen, M., Dutra-Clarke, A., Fazio, M., Vijai, J., Stadler, Z., Kauff, N., Kirchhoff, T., Hudis, C., Offit, K., Robson, M.

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Assessment of the prevalence of de novo mutations in the BRCA1 and BRCA2 genes von Zhang, L, Fleischut, MH, Kohut, K, Spencer, S, Wong, K, Stadler, ZK, Kauff, ND, Offit, K, Robson, ME

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Risk of Radiation-Associated Secondary Malignancies among Patients with Breast Cancer Harboring TP53 Germline Variants von Cederquist, G., Boe, L., Walsh, M.F., Stadler, Z., Xu, A.J., Mueller, B.A., Roth O'Brien, D.A., Bernstein, M.B., Cuaron, J., Bakhoum, S.F., Powell, S.N., Khan, A.J., Robson, M.E., Maxwell, K., Taunk, N.K., Braunstein, L.Z.

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Topic: AS07-Singular Entities/Subtypes/AS07a-ARCH, CCUS, ICUS: RARE GENETIC DETERMINANTS OF CLONAL HEMATOPOIESIS AND PROGRESSION TO HEMATOLOGIC MALIGNANCIES von Liu, J., Wiley, B., Chan, I., Batchi-Bouyou, A., Zong, X., Ding, L., Cao, Y., Offit, K., Stadler, Z., Link, D., Bolton, K.

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O-5 Frequency of minimal residual disease as measured by ctDNA in mismatch repair deficient tumors following curative resection von Janjigian, Y., Lumish, M., Jayakumaran, G., Fox, M., Sabwa, S., Cercek, A., Stadler, Z., Ku, G., Segal, N., Won, E., Maron, S., Troso-Sandoval, T., Segal, M., Strong, V., Molena, D., Weiser, M., Jones, D., Zehir, A., Berger, M., Diaz, L.

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Induction Chemotherapy Reduces Patient-Reported Toxicities During Neoadjuvant Chemoradiation with Intensity Modulated Radiation Therapy for Rectal Cancer von Ng, S.Y., Colborn, K., Cambridge, L., Cercek, A., Reidy, D., Segal, N., Stadler, Z., Saltz, L., Garcia-Aguilar, J., Goodman, K.A.

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T.02.1 DELPHI INITIATIVE FOR EARLY-ONSET COLORECTAL CANCER (DIRECT): INTERNATIONAL MANAGEMENT GUIDELINES von Cavestro, G.M., Mannucci, A., Balaguer, F., Heather, H., Kupfer, S., Repici, A., Sartore-Bianchi, A., Seppala, T., Valentini, V., Boland, C., Brand, R., Buffart, T., Burke, C., Caccialanza, R., Cannizzaro, R., Cascinu, S., Cercek, A., Crosbie, E., Danese, S., Dekker, E., Daca-Alvarez, M., Deni, F., Latchford, A., Liska, D., Lynch, P., Malesci, A., Mauri, G., Meldolesi, E., Pal, M., Monahan, K., Moslein, G., Murphy, C., Nass, K., Ng, K., Oliani, C., Papaleo, E., Patel, S., Puzzono, M., Remo, A., Ricciardiello, L., Ripamonti, C., Siena, S., Singh, S., Stadler, Z., Stanich, P., Syngal, S., Turi, S., Urso, E., Valle, L., Vanni, V., Vilar, E., Vitellaro, M., You, Y., Yurgelun, M., Zuppardo, R., Stoffel, E.

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Friction behavior of sintered metallic brake pads on a C/C–SiC composite brake disc von Stadler, Zmago, Krnel, Kristoffer, Kosmac, Tomaz

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591PComparing metastatic (M) young onset (YO) colorectal cancer (CRC) with average onset (AO): Do they differ clinically and genetically? von Dos Santos Fernandes, G, Chatila, W, Yaeger, R, Mendelsohn, R, Stadler, Z, Segal, N H, Varghese, A, Reidy, D, Diaz, L, Shia, J, Vakiani, E, Hechtman, J, Schultz, N, Berger, M, Hyman, D, Solit, D, Saltz, L, Garcia Aguilar, J, Cercek, A

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