Metabolism-guided discovery of a potent and orally bioavailable urea-based calcimimetic for the treatment of secondary hyperparathyroidism von Wehn, Paul M., Harrington, Paul E., Carlson, Timothy J., Davis, James, Deprez, Pierre, Fotsch, Christopher H., Grillo, Mark P., Lu, Jenny Ying-Lin, Morony, Sean, Pattabiraman, Kanaka, Poon, Steve F., Reagan, Jeff D., St. Jean, David J., Temal, Taoues, Wang, Minghan, Yang, Yuhua, Henley, Charles, Lively, Sarah E.

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors von Lloyd, David J., St Jean, David J., Kurzeja, Robert J. M., Wahl, Robert C., Michelsen, Klaus, Cupples, Rod, Chen, Michelle, Wu, John, Sivits, Glenn, Helmering, Joan, Komorowski, Renée, Ashton, Kate S., Pennington, Lewis D., Fotsch, Christopher, Vazir, Mukta, Chen, Kui, Chmait, Samer, Zhang, Jiandong, Liu, Longbin, Norman, Mark H., Andrews, Kristin L., Bartberger, Michael D., Van, Gwyneth, Galbreath, Elizabeth J., Vonderfecht, Steven L., Wang, Minghan, Jordan, Steven R., Véniant, Murielle M., Hale, Clarence

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Mitigating Heterocycle Metabolism in Drug Discovery von St. Jean, David J, Fotsch, Christopher

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From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) von Cheng, Yuan, Judd, Ted C, Bartberger, Michael D, Brown, James, Chen, Kui, Fremeau, Robert T, Hickman, Dean, Hitchcock, Stephen A, Jordan, Brad, Li, Vivian, Lopez, Patricia, Louie, Steven W, Luo, Yi, Michelsen, Klaus, Nixey, Thomas, Powers, Timothy S, Rattan, Claire, Sickmier, E. Allen, St. Jean, David J, Wahl, Robert C, Wen, Paul H, Wood, Stephen

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STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts von Buckbinder, Leonard, St Jean, Jr, David J, Tieu, Trang, Ladd, Brendon, Hilbert, Brendan, Wang, Weixue, Alltucker, Jacob T, Manimala, Samantha, Kryukov, Gregory V, Brooijmans, Natasja, Dowdell, Gregory, Jonsson, Philip, Huff, Michael, Guzman-Perez, Angel, Jackson, Erica L, Goncalves, Marcus D, Stuart, Darrin D

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Structural Characterization and Pharmacodynamic Effects of an Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor von Hale, Clarence, Véniant, Murielle, Wang, Zhulun, Chen, Michelle, McCormick, Jocelyn, Cupples, Rod, Hickman, Dean, Min, Xiaoshan, Sudom, Athena, Xu, Haoda, Matsumoto, Guy, Fotsch, Christopher, St. Jean, David J. Jr, Wang, Minghan

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Next-generation small molecule therapies for heart failure: 2015 and beyond von Malinowski, Justin T., St. Jean, David J.

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the N‑Arylsulfonamid... von Nishimura, Nobuko, Norman, Mark H, Liu, Longbin, Yang, Kevin C, Ashton, Kate S, Bartberger, Michael D, Chmait, Samer, Chen, Jie, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steven R, Kunz, Roxanne K, Pennington, Lewis D, Poon, Steve F, Siegmund, Aaron, Sivits, Glenn, Lloyd, David J, Hale, Clarence, St. Jean, David J

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis von Tamayo, Nuria A, Norman, Mark H, Bartberger, Michael D, Hong, Fang-Tsao, Bo, Yunxin, Liu, Longbin, Nishimura, Nobuko, Yang, Kevin C, Tadesse, Seifu, Fotsch, Christopher, Chen, Jie, Chmait, Samer, Cupples, Rod, Hale, Clarence, Jordan, Steven R, Lloyd, David J, Sivits, Glenn, Van, Gwyneth, St. Jean, David J

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept von Ashton, Kate S., Andrews, Kristin L., Bryan, Marion C., Chen, Jie, Chen, Kui, Chen, Michelle, Chmait, Samer, Croghan, Michael, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steve R., Kurzeja, Robert J. M., Michelsen, Klaus, Pennington, Lewis D., Poon, Steve F., Sivits, Glenn, Van, Gwyneth, Vonderfecht, Steve L., Wahl, Robert C., Zhang, Jiandong, Lloyd, David J., Hale, Clarence, St. Jean, David J.

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 4. Exploration of a Novel Binding Pocket von Hong, Fang-Tsao, Norman, Mark H, Ashton, Kate S, Bartberger, Michael D, Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Jordan, Steven R, Lloyd, David J, Sivits, Glenn, Tadesse, Seifu, Hale, Clarence, St. Jean, David J

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Discovery of a calcimimetic with differential effects on parathyroid hormone and calcitonin secretion von Henley, 3rd, Charles, Yang, Yuhua, Davis, James, Lu, Jenny Ying Lin, Morony, Sean, Fan, Wei, Florio, Monica, Sun, Banghua, Shatzen, Edward, Pretorius, James K, Richards, William G, St Jean, Jr, David J, Fotsch, Christopher, Reagan, Jeff D

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Oxopyrido[2,3‑d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors von Wurz, Ryan P, Pettus, Liping H, Ashton, Kate, Brown, James, Chen, Jian Jeffrey, Herberich, Brad, Hong, Fang-Tsao, Hu-Harrington, Essa, Nguyen, Tom, St. Jean, David J, Tadesse, Seifu, Bauer, David, Kubryk, Michele, Zhan, Jinghui, Cooke, Keegan, Mitchell, Petia, Andrews, Kristin L, Hsieh, Faye, Hickman, Dean, Kalyanaraman, Nataraj, Wu, Tian, Reid, Darren L, Lobenhofer, Edward K, Andrews, Dina A, Everds, Nancy, Guzman, Roberto, Parsons, Andrew T, Hedley, Simon J, Tedrow, Jason, Thiel, Oliver R, Potter, Matthew, Radinsky, Robert, Beltran, Pedro J, Tasker, Andrew S

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Discovery and Optimization of Substituted 1-(1-Phenyl-1H-pyrazol-3-yl)methanamines as Potent and Efficacious Type II Calcimimetics von Poon, Steve F, St. Jean, David J, Harrington, Paul E, Henley, Charles, Davis, James, Morony, Sean, Lott, Fred D, Reagan, Jeff D, Lu, Jenny Ying-Lin, Yang, Yuhua, Fotsch, Christopher

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Discovery of Small-Molecule Glucokinase Regulatory Protein Modulators That Restore Glucokinase Activity von Chen, Kui, Michelsen, Klaus, Kurzeja, Robert J.M., Han, Joon, Vazir, Mukta, St. Jean, David J., Hale, Clarence, Wahl, Robert C.

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Methods for treating cancer von St. Jean, Jr., David

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A General Route toward the Synthesis of the Cladiellin Skeleton Utilizing a SmI2-Mediated Cyclization von Molander, Gary A, Czakó, Barbara, St. Jean, David J

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Methods for treating cancer von St. Jean, Jr., David

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Small molecules with potent osteogenic-inducing activity in osteoblast cells von Han, Chun-Ya E., Wang, Youping, Yu, Longchuan, Powers, David, Xiong, Xiaoling, Yu, Violeta, Nguyen, Yen, Jean, David J. St, Babij, Philip

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A tandem cross-coupling/S(N)Ar approach to functionalized carbazoles von St Jean, Jr, David J, Poon, Steve F, Schwarzbach, Jamie L

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