Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance von Shaffer, Sydney M., Dunagin, Margaret C., Torborg, Stefan R., Torre, Eduardo A., Emert, Benjamin, Krepler, Clemens, Beqiri, Marilda, Sproesser, Katrin, Brafford, Patricia A., Xiao, Min, Eggan, Elliott, Anastopoulos, Ioannis N., Vargas-Garcia, Cesar A., Singh, Abhyudai, Nathanson, Katherine L., Herlyn, Meenhard, Raj, Arjun

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Discovery of a Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Antimelanoma Activity von Tsai, James, Lee, John T., Wang, Weiru, Zhang, Jiazhong, Cho, Hanna, Mamo, Shumeye, Bremer, Ryan, Gillette, Sam, Kong, Jun, Haass, Nikolas K., Sproesser, Katrin, Li, Ling, Smalley, Keiran S. M., Fong, Daniel, Zhu, Yong-Liang, Marimuthu, Adhirai, Nguyen, Hoa, Lam, Billy, Liu, Jennifer, Cheung, Ivana, Rice, Julie, Suzuki, Yoshihisa, Luu, Catherine, Settachatgul, Calvin, Shellooe, Rafe, Cantwell, John, Kim, Sung-Hou, Schlessinger, Joseph, Zhang, Kam Y. J., West, Brian L., Powell, Ben, Habets, Gaston, Zhang, Chao, Ibrahim, Prabha N., Hirth, Peter, Artis, Dean R., Herlyn, Meenhard, Bollag, Gideon

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Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence von Singleton, Katherine R., Crawford, Lorin, Tsui, Elizabeth, Manchester, Haley E., Maertens, Ophelia, Liu, Xiaojing, Liberti, Maria V., Magpusao, Anniefer N., Stein, Elizabeth M., Tingley, Jennifer P., Frederick, Dennie T., Boland, Genevieve M., Flaherty, Keith T., McCall, Shannon J., Krepler, Clemens, Sproesser, Katrin, Herlyn, Meenhard, Adams, Drew J., Locasale, Jason W., Cichowski, Karen, Mukherjee, Sayan, Wood, Kris C.

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The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase Inhibitor AZD6244 (ARRY-142886) Induces Growth Arrest in Melanoma Cells and Tumor Regression When Combine... von HAASS, Nikolas K, SPROESSER, Katrin, NGUYEN, Thiennga K, CONTRACTOR, Rooha, MEDINA, C. Angelica, NATHANSON, Katherine L, HERLYN, Meenhard, SMALLEY, Keiran S. M

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Concurrent MEK2 Mutation and BRAF Amplification Confer Resistance to BRAF and MEK Inhibitors in Melanoma von Villanueva, Jessie, Infante, Jeffrey R., Krepler, Clemens, Reyes-Uribe, Patricia, Samanta, Minu, Chen, Hsin-Yi, Li, Bin, Swoboda, Rolf K., Wilson, Melissa, Vultur, Adina, Fukunaba-Kalabis, Mizuho, Wubbenhorst, Bradley, Chen, Thomas Y., Liu, Qin, Sproesser, Katrin, DeMarini, Douglas J., Gilmer, Tona M., Martin, Anne-Marie, Marmorstein, Ronen, Schultz, David C., Speicher, David W., Karakousis, Giorgos C., Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Schuchter, Lynn M., Herlyn, Meenhard, Nathanson, Katherine L.

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Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines von Garman, Bradley, Anastopoulos, Ioannis N., Krepler, Clemens, Brafford, Patricia, Sproesser, Katrin, Jiang, Yuchao, Wubbenhorst, Bradley, Amaravadi, Ravi, Bennett, Joseph, Beqiri, Marilda, Elder, David, Flaherty, Keith T., Frederick, Dennie T., Gangadhar, Tara C., Guarino, Michael, Hoon, David, Karakousis, Giorgos, Liu, Qin, Mitra, Nandita, Petrelli, Nicholas J., Schuchter, Lynn, Shannan, Batool, Shields, Carol L., Wargo, Jennifer, Wenz, Brandon, Wilson, Melissa A., Xiao, Min, Xu, Wei, Xu, Xaiowei, Yin, Xiangfan, Zhang, Nancy R., Davies, Michael A., Herlyn, Meenhard, Nathanson, Katherine L.

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Acetylsalicylic Acid Governs the Effect of Sorafenib in RAS -Mutant Cancers von Hammerlindl, Heinz, Ravindran Menon, Dinoop, Hammerlindl, Sabrina, Emran, Abdullah Al, Torrano, Joachim, Sproesser, Katrin, Thakkar, Divya, Xiao, Min, Atkinson, Victoria G, Gabrielli, Brian, Haass, Nikolas K, Herlyn, Meenhard, Krepler, Clemens, Schaider, Helmut

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PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas von Lee, John T., Li, Ling, Brafford, Patricia A., van den Eijnden, Marcia, Halloran, Molly B., Sproesser, Katrin, Haass, Nikolas K., Smalley, Keiran S.M., Tsai, James, Bollag, Gideon, Herlyn, Meenhard

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Oncogenic BRAF-Mediated Melanoma Cell Invasion von Lu, Hezhe, Liu, Shujing, Zhang, Gao, Kwong, Lawrence N., Zhu, Yueyao, Miller, John P., Hu, Yi, Zhong, Wenqun, Zeng, Jingwen, Wu, Lawrence, Krepler, Clemens, Sproesser, Katrin, Xiao, Min, Xu, Wei, Karakousis, Giorgos C., Schuchter, Lynn M., Field, Jeffery, Zhang, Paul J., Herlyn, Meenhard, Xu, Xiaowei, Guo, Wei

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Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors von Zhang, Gao, Frederick, Dennie T, Wu, Lawrence, Wei, Zhi, Krepler, Clemens, Srinivasan, Satish, Chae, Young Chan, Xu, Xiaowei, Choi, Harry, Dimwamwa, Elaida, Ope, Omotayo, Shannan, Batool, Basu, Devraj, Zhang, Dongmei, Guha, Manti, Xiao, Min, Randell, Sergio, Sproesser, Katrin, Xu, Wei, Liu, Jephrey, Karakousis, Giorgos C, Schuchter, Lynn M, Gangadhar, Tara C, Amaravadi, Ravi K, Gu, Mengnan, Xu, Caiyue, Ghosh, Abheek, Xu, Weiting, Tian, Tian, Zhang, Jie, Zha, Shijie, Liu, Qin, Brafford, Patricia, Weeraratna, Ashani, Davies, Michael A, Wargo, Jennifer A, Avadhani, Narayan G, Lu, Yiling, Mills, Gordon B, Altieri, Dario C, Flaherty, Keith T, Herlyn, Meenhard

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PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas von Lu, Hezhe, Liu, Shujing, Zhang, Gao, Bin Wu, Zhu, Yueyao, Frederick, Dennie T., Hu, Yi, Zhong, Wenqun, Randell, Sergio, Sadek, Norah, Zhang, Wei, Chen, Gang, Cheng, Chaoran, Zeng, Jingwen, Wu, Lawrence W., Zhang, Jie, Liu, Xiaoming, Xu, Wei, Krepler, Clemens, Sproesser, Katrin, Xiao, Min, Miao, Benchun, Liu, Jianglan, Song, Claire D., Liu, Jephrey Y., Karakousis, Giorgos C., Schuchter, Lynn M., Lu, Yiling, Mills, Gordon, Cong, Yusheng, Chernoff, Jonathan, Guo, Jun, Boland, Genevieve M., Sullivan, Ryan J., Wei, Zhi, Field, Jeffrey, Amaravadi, Ravi K., Flaherty, Keith T., Herlyn, Meenhard, Xu, Xiaowei, Guo, Wei

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Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies von Krepler, Clemens, Xiao, Min, Sproesser, Katrin, Brafford, Patricia A, Shannan, Batool, Beqiri, Marilda, Liu, Qin, Xu, Wei, Garman, Bradley, Nathanson, Katherine L, Xu, Xiaowei, Karakousis, Giorgos C, Mills, Gordon B, Lu, Yiling, Ahmed, Tamer A, Poulikakos, Poulikos I, Caponigro, Giordano, Boehm, Markus, Peters, Malte, Schuchter, Lynn M, Weeraratna, Ashani T, Herlyn, Meenhard

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Targeting RRM2 and Mutant BRAF Is a Novel Combinatorial Strategy for Melanoma von Fatkhutdinov, Nail, Sproesser, Katrin, Krepler, Clemens, Liu, Qin, Brafford, Patricia A, Herlyn, Meenhard, Aird, Katherine M, Zhang, Rugang

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Abstract 5662: JNJ-67571244: A novel anti-CD33 C2 domain binding bispecific antibody with potent T cell redirection activity von Nair-Gupta, Priyanka, Diem, Michael, Reeves, Dara, Wang, Weirong, Schulingkamp, Robert, Sproesser, Katrin, Mattson, Bethany, Heidrich, Bradley, Joseph, Jocelin, Sendecki, Jocelyn, Foulk, Brad, Chu, Gerald, Fink, Damien, Jiao, Qun, Wu, Sheng-Jiun, Packman, Kathryn, Elsayed, Yusri, Attar, Ricardo, Gaudet, Francois

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Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance von Liu, Jianglan, Rebecca, Vito W, Kossenkov, Andrew V, Connelly, Thomas, Liu, Qin, Gutierrez, Alexis, Xiao, Min, Li, Ling, Zhang, Gao, Samarkina, Anastasia, Zayasbazan, Delaine, Zhang, Jie, Cheng, Chaoran, Wei, Zhi, Alicea, Gretchen M, Fukunaga-Kalabis, Mizuho, Krepler, Clemens, Aza-Blanc, Pedro, Yang, Chih-Cheng, Delvadia, Bela, Tong, Cynthia, Huang, Ye, Delvadia, Maya, Morias, Alice S, Sproesser, Katrin, Brafford, Patricia, Wang, Joshua X, Beqiri, Marilda, Somasundaram, Rajasekharan, Vultur, Adina, Hristova, Denitsa M, Wu, Lawrence W, Lu, Yiling, Mills, Gordon B, Xu, Wei, Karakousis, Giorgos C, Xu, Xiaowei, Schuchter, Lynn M, Mitchell, Tara C, Amaravadi, Ravi K, Kwong, Lawrence N, Frederick, Dennie T, Boland, Genevieve M, Salvino, Joseph M, Speicher, David W, Flaherty, Keith T, Ronai, Ze'ev A, Herlyn, Meenhard

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Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma von Zhang, Gao, Wu, Lawrence W, Mender, Ilgen, Barzily-Rokni, Michal, Hammond, Marc R, Ope, Omotayo, Cheng, Chaoran, Vasilopoulos, Themistoklis, Randell, Sergio, Sadek, Norah, Beroard, Aurelie, Xiao, Min, Tian, Tian, Tan, Jiufeng, Saeed, Umar, Sugarman, Eric, Krepler, Clemens, Brafford, Patricia, Sproesser, Katrin, Murugan, Sengottuvelan, Somasundaram, Rajasekharan, Garman, Bradley, Wubbenhorst, Bradley, Woo, Jonathan, Yin, Xiangfan, Liu, Qin, Frederick, Dennie T, Miao, Benchun, Xu, Wei, Karakousis, Giorgos C, Xu, Xiaowei, Schuchter, Lynn M, Mitchell, Tara C, Kwong, Lawrence N, Amaravadi, Ravi K, Lu, Yiling, Boland, Genevieve M, Wei, Zhi, Nathanson, Katherine, Herbig, Utz, Mills, Gordon B, Flaherty, Keith T, Herlyn, Meenhard, Shay, Jerry W

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A novel C2 domain binding CD33xCD3 bispecific antibody with potent T-cell redirection activity against acute myeloid leukemia von Nair-Gupta, Priyanka, Diem, Michael, Reeves, Dara, Wang, Weirong, Schulingkamp, Robert, Sproesser, Katrin, Mattson, Bethany, Heidrich, Bradley, Mendonça, Mark, Joseph, Jocelin, Sendecki, Jocelyn, Foulk, Brad, Chu, Gerald, Fink, Damien, Jiao, Qun, Wu, Sheng-Jiun, Packman, Kathryn, Elsayed, Yusri, Attar, Ricardo, Gaudet, François

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Induction of cellular immunity by anti-idiotypic antibodies mimicking GD2 ganglioside von BASAK, Saroj, BIREBENT, Brigitte, HONG SONG, JIAN LI, SPROESSER, Katrin, GUERRY, Dupont, NAIR, Sridar, FURUKAWA, Koichi, HERLYN, Dorothee, PUREV, Enkhtsetseg, SOMASUNDARAM, Rajasekharan, MARUYAMA, Haruhiko, ZALOUDIK, Jan, SWOBODA, Rolf, STRITTMATTER, Wolfgang, WEIPING LI, LUCKENBACH, Albrecht

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Corrigendum: Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance von Shaffer, Sydney M, Dunagin, Margaret C, Torborg, Stefan R, Torre, Eduardo A, Emert, Benjamin, Krepler, Clemens, Beqiri, Marilda, Sproesser, Katrin, Brafford, Patricia A, Xiao, Min, Eggan, Elliott, Anastopoulos, Ioannis N, Vargas-Garcia, Cesar A, Singh, Abhyudai, Nathanson, Katherine L, Herlyn, Meenhard, Raj, Arjun

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Correction: Corrigendum: Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance von Shaffer, Sydney M., Dunagin, Margaret C., Torborg, Stefan R., Torre, Eduardo A., Emert, Benjamin, Krepler, Clemens, Beqiri, Marilda, Sproesser, Katrin, Brafford, Patricia A., Xiao, Min, Eggan, Elliott, Anastopoulos, Ioannis N., Vargas-Garcia, Cesar A., Singh, Abhyudai, Nathanson, Katherine L., Herlyn, Meenhard, Raj, Arjun

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