Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF von Heidorn, Sonja J., Milagre, Carla, Whittaker, Steven, Nourry, Arnaud, Niculescu-Duvas, Ion, Dhomen, Nathalie, Hussain, Jahan, Reis-Filho, Jorge S., Springer, Caroline J., Pritchard, Catrin, Marais, Richard

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Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF von Wan, Paul T.C, Garnett, Mathew J, Roe, S.Mark, Lee, Sharlene, Niculescu-Duvaz, Dan, Good, Valerie M, Project, Cancer Genome, Jones, C.Michael, Marshall, Christopher J, Springer, Caroline J, Barford, David, Marais, Richard

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Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes von Pedersen, Malin, Küsters-Vandevelde, Heidi V N, Viros, Amaya, Groenen, Patricia J T A, Sanchez-Laorden, Berta, Gilhuis, Jacobus H, van Engen-van Grunsven, Ilse A, Renier, Willy, Schieving, Jolanda, Niculescu-Duvaz, Ion, Springer, Caroline J, Küsters, Benno, Wesseling, Pieter, Blokx, Willeke A M, Marais, Richard

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Attenuated Salmonella Targets Prodrug Activating Enzyme Carboxypeptidase G2 to Mouse Melanoma and Human Breast and Colon Carcinomas for Effective Suicide Gene Therapy von FRIEDLOS, Frank, LEHOURITIS, Panos, OGILVIE, Lesley, MEDLEY, Douglas, DAVIES, Lawrence, BERMUDES, David, KING, Ivan, MARTIN, Jan, MARAIS, Richard, SPRINGER, Caroline J

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Synthesis of Novel Cationic Lipids:  Effect of Structural Modification on the Efficiency of Gene Transfer von Heyes, James A, Niculescu-Duvaz, Dan, Cooper, Robert G, Springer, Caroline J

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Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography von Li, Jin, Zormpas-Petridis, Konstantinos, Boult, Jessica K R, Reeves, Emma L, Heindl, Andreas, Vinci, Maria, Lopes, Filipa, Cummings, Craig, Springer, Caroline J, Chesler, Louis, Jones, Chris, Bamber, Jeffrey C, Yuan, Yinyin, Sinkus, Ralph, Jamin, Yann, Robinson, Simon P

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A Phase I Study of Single Administration of Antibody-Directed Enzyme Prodrug Therapy with the Recombinant Anti–Carcinoembryonic Antigen Antibody-Enzyme Fusion Protein MFECP1 and a... von Mayer, Astrid, Francis, Roslyn J, Sharma, Surinder K, Tolner, Berend, Springer, Caroline J, Martin, Jan, Boxer, Geoff M, Bell, James, Green, Alan J, Hartley, John A, Cruickshank, Clare, Wren, Julie, Chester, Kerry A, Begent, Richard H J

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Small molecule inhibitors of BRAF in clinical trials von Zambon, Alfonso, Niculescu-Duvaz, Ion, Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J

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B-RAF is a therapeutic target in melanoma von Karasarides, Maria, Chiloeches, Antonio, Hayward, Robert, Niculescu-Duvaz, Dan, Scanlon, Ian, Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Martin, Jan, Marshall, Christopher J, Springer, Caroline J, Marais, Richard

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Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma von Bridgeman, Victoria L, Wan, Elaine, Foo, Shane, Nathan, Mark R, Welti, Jonathan C, Frentzas, Sophia, Vermeulen, Peter B, Preece, Natasha, Springer, Caroline J, Powles, Thomas, Nathan, Paul D, Larkin, James, Gore, Martin, Vasudev, Naveen S, Reynolds, Andrew R

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A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of V600EBRAF von WHITTAKER, Steven, MENARD, Delphine, LAMBROS, Maryou, REIS-FILHO, Jorge S, MARAIS, Richard, SPRINGER, Caroline J, KIRK, Ruth, OGILVIE, Lesley, HEDLEY, Douglas, ZAMBON, Alfonso, LOPES, Filipa, PREECE, Natasha, MANNE, Helen, RANA, Sareena

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Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents von Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Davies, Lawrence, Pons, Jean-Francois, Whittaker, Steven, Marais, Richard, Springer, Caroline J.

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Novel Fluorinated Prodrugs for Activation by Carboxypeptidase G2 Showing Good in Vivo Antitumor Activity in Gene-Directed Enzyme Prodrug Therapy von Davies, Lawrence C, Friedlos, Frank, Hedley, Douglas, Martin, Jan, Ogilvie, Lesley M, Scanlon, Ian J, Springer, Caroline J

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Hyperpolarized 13C magnetic resonance detection of carboxypeptidase G2 activity von Jamin, Yann, Gabellieri, Cristina, Smyth, Lynette, Reynolds, Steven, Robinson, Simon P., Springer, Caroline J., Leach, Martin O., Payne, Geoffrey S., Eykyn, Thomas R.

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Contrasting effects of sunitinib within in vivo models of metastasis von Welti, Jonathan C., Powles, Thomas, Foo, Shane, Gourlaouen, Morgane, Preece, Natasha, Foster, Julie, Frentzas, Sophia, Bird, Demelza, Sharpe, Kevin, van Weverwijk, Antoinette, Robertson, David, Soffe, Julie, Erler, Janine T., Pili, Roberto, Springer, Caroline J., Mather, Stephen J., Reynolds, Andrew R.

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Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates von Senter, Peter D, Springer, Caroline J

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Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2 von SCHEPELMANN, Silke, OGILVIE, Lesley M, HEDLEY, Douglas, FRIEDLOS, Frank, MARTIN, Janet, SCANLON, Ian, PING CHEN, MARAIS, Richard, SPRINGER, Caroline J

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Long Functionalized Poly(ethylene glycol)s of Defined Molecular Weight: Synthesis and Application in Solid-Phase Synthesis of Conjugates von Niculescu-Duvaz, Dan, Getaz, Jayne, Springer, Caroline J

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Novel Hinge Binder Improves Activity and Pharmacokinetic Properties of BRAF Inhibitors von Zambon, Alfonso, Ménard, Delphine, Suijkerbuijk, Bart M. J. M, Niculescu-Duvaz, Ion, Whittaker, Steven, Niculescu-Duvaz, Dan, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A, Lopes, Filipa, Preece, Natasha, Hedley, Douglas, Ogilvie, Lesley M, Kirk, Ruth, Marais, Richard, Springer, Caroline J

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation von Mason, Clive S., Springer, Caroline J., Cooper, Robert G, Superti-Furga, Giulio, Marshall, Christopher J., Marais, Richard

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