Type IIA topoisomerase inhibition by a new class of antibacterial agents von Giordano, Ilaria, Spitzfaden, Claus E, Jones, Emma, Theobald, Andrew J, Gorrec, Fabrice, Jones, Jo, Hann, Michael M, May, Earl W, Saunders, Martin R, Fosberry, Andrew, Chan, Pan F, Eggleston, Drake S, Hibbs, Martin, Brown, Kristin Koretke, Lewis, Ceri J, Bax, Benjamin D, Singh, Onkar, Pearson, Neil D, Wohlkonig, Alexandre, Hennessy, Alan, Gentry, Daniel R, Huang, Jianzhong, Shen, Carol, Gwynn, Michael N, Shillings, Anthony

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Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin von Chan, Pan F., Srikannathasan, Velupillai, Huang, Jianzhong, Cui, Haifeng, Fosberry, Andrew P., Gu, Minghua, Hann, Michael M., Hibbs, Martin, Homes, Paul, Ingraham, Karen, Pizzollo, Jason, Shen, Carol, Shillings, Anthony J., Spitzfaden, Claus E., Tanner, Robert, Theobald, Andrew J., Stavenger, Robert A., Bax, Benjamin D., Gwynn, Michael N.

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Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients von Lekova, Eleonora, Zelek, Wioleta M., Gower, David, Spitzfaden, Claus, Osuch, Isabelle H., John-Morris, Elen, Stach, Lasse, Gormley, Darren, Sanderson, Andrew, Bridges, Angela, Wear, Elizabeth R., Petit-Frere, Sebastien, Burden, Michael N., Priest, Richard, Wattam, Trevor, Kitchen, Semra J., Feeney, Maria, Davis, Susannah, Morgan, B. Paul, Nichols, Eva-Maria

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Structural Requirements for Biological Activity of the Ninth and Tenth FIII Domains of Human Fibronectin von Grant, Richard P., Spitzfaden, Claus, Altroff, Harri, Campbell, Iain D., Mardon, Helen J.

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A comparison of the folding kinetics and thermodynamics of two homologous fibronectin type III modules von Plaxco, Kevin W, Spitzfaden, Claus, Campbell, Iain D, Dobson, Christopher M

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The structure of ribonuclease P protein from Staphylococcus aureus reveals a unique binding site for single-stranded RNA von Spitzfaden, Claus, Nicholson, Neville, Jones, Jo J, Guth, Sabine, Lehr, Ruth, Prescott, Cathy D, Hegg, Lisa A, Eggleston, Drake S

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Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion von Agrawal, Alka, Roué, Mélanie, Spitzfaden, Claus, Petrella, Stéphanie, Aubry, Alexandra, Hann, Michael, Bax, Benjamin, Mayer, Claudine

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Module-module interactions in the cell binding region of fibronectin: stability, flexibility and specificity von Spitzfaden, Claus, Grant, Richard P, Mardon, Helen J, Campbell, Iain D

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Destabilization of the complete protein secondary structure on binding to the chaperone GroEL von Zahn, Ralph, Spitzfaden, Claus, Ottiger, Marcel, Wüthrich, Kurt, Plückthun, Andreas

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Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy von Kallen, Jörg, Spitzfaden, Claus, Zurini, Mauro G. M, Wider, Gerhard, Widmer, Hans, Wüthrich, Kurt, Walkinshaw, Malcolm D

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Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening von Borthwick, Jennifer A, Ancellin, Nicolas, Bertrand, Sophie M, Bingham, Ryan P, Carter, Paul S, Chung, Chun-wa, Churcher, Ian, Dodic, Nerina, Fournier, Charlène, Francis, Peter L, Hobbs, Andrew, Jamieson, Craig, Pickett, Stephen D, Smith, Sarah E, Somers, Donald O’N, Spitzfaden, Claus, Suckling, Colin J, Young, Robert J

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The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits von Bertrand, Sophie M, Ancellin, Nicolas, Beaufils, Benjamin, Bingham, Ryan P, Borthwick, Jennifer A, Boullay, Anne-Bénédicte, Boursier, Eric, Carter, Paul S, Chung, Chun-wa, Churcher, Ian, Dodic, Nerina, Fouchet, Marie-Hélène, Fournier, Charlène, Francis, Peter L, Gummer, Laura A, Herry, Kenny, Hobbs, Andrew, Hobbs, Clare I, Homes, Paul, Jamieson, Craig, Nicodeme, Edwige, Pickett, Stephen D, Reid, Iain H, Simpson, Graham L, Sloan, Lisa A, Smith, Sarah E, Somers, Donald O’N, Spitzfaden, Claus, Suckling, Colin J, Valko, Klara, Washio, Yoshiaki, Young, Robert J

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Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases von Miles, Timothy J., Hennessy, Alan J., Bax, Ben, Brooks, Gerald, Brown, Barry S., Brown, Pamela, Cailleau, Nathalie, Chen, Dongzhao, Dabbs, Steven, Davies, David T., Esken, Joel M., Giordano, Ilaria, Hoover, Jennifer L., Huang, Jianzhong, Jones, Graham E., Kusalakumari Sukmar, Senthill K., Spitzfaden, Claus, Markwell, Roger E., Minthorn, Elisabeth A., Rittenhouse, Steve, Gwynn, Michael N., Pearson, Neil D.

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Inhibitors of the DNA-cleavage gate of bacterial type IIA topoisomerases von Bax, Ben, Fosberry, Andrew, Spitzfaden, Claus, Shillings, Anthony, Pearson, Neil, Chan, Pan, Huang, Jianzhong

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Cyclosporin A—cyclophilin complex formation A model based on X-ray and NMR data von Spitzfaden, Claus, Weber, Hans-Peter, Braun, Werner, Kallen, Joerg, Wider, Gerhard, Widmer, Hans, Walkinshaw, Malcolm D., Wüthrich, Kurt

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Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide von Srikannathasan, Velupillai, Wohlkonig, Alexandre, Shillings, Anthony, Singh, Onkar, Chan, Pan F., Huang, Jianzhong, Gwynn, Michael N., Fosberry, Andrew P., Homes, Paul, Hibbs, Martin, Theobald, Andrew J., Spitzfaden, Claus, Bax, Benjamin D.

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Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans von Howlett, D R, Perry, A E, Godfrey, F, Swatton, J E, Jennings, K H, Spitzfaden, C, Wadsworth, H, Wood, S J, Markwell, R E

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Building proteins with fibronectin type III modules von Campbell, Iain D, Spitzfaden, Claus

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Rapid Refolding of a Proline-Rich all-$\beta $-sheet Fibronectin Type III Module von Plaxco, Kevin W., Spitzfaden, Claus, Campbell, Iain D., Dobson, Christopher M.

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Structural studies on bacterial type IIA topoisomerases - targets for quinolone and coumarin antibiotics von Bax, Ben, Hibbs, Martin, Jones, Emma, Theobald, Andrew, Fosberry, Andrew, Spitzfaden, Claus, Shillings, Anthony, Wohlkonig, Alexandre, Koretke, Kristin K., Huang, Jianzhong, Pearson, Neil, Gwynn, Michael N.

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