Alternative molecular formats and therapeutic applications for bispecific antibodies von Spiess, Christoph, Zhai, Qianting, Carter, Paul J.

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The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions von Frydman, Judith, Tam, Stephen, Geller, Ron, Spiess, Christoph

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Plasma membrane damage limits cytoplasmic delivery by conventional cell penetrating peptides von Polderdijk, Stéphanie G I, Limzerwala, Jazeel F, Spiess, Christoph

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A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma von Kakiuchi-Kiyota, Satoko, Ross, Thorsten, Wallweber, Heidi Ackerly, Kiefer, James R., Schutten, Melissa M., Adedeji, Adeyemi O., Cai, Hao, Hendricks, Robert, Cohen, Sivan, Myneni, Srividya, Liu, Luna, Fullerton, Aaron, Corr, Nicholas, Yu, Lanlan, de Almeida Nagata, Denise, Zhong, Shelly, Leong, Steven R., Li, Ji, Nakamura, Rin, Sumiyoshi, Teiko, Li, Jinze, Ovacik, Ayse Meric, Zheng, Bing, Dillon, Mike, Spiess, Christoph, Wingert, Susanne, Rajkovic, Erich, Ellwanger, Kristina, Reusch, Uwe, Polson, Andrew G.

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Prediction of methionine oxidation risk in monoclonal antibodies using a machine learning method von Sankar, Kannan, Hoi, Kam Hon, Yin, Yizhou, Ramachandran, Prasanna, Andersen, Nisana, Hilderbrand, Amy, McDonald, Paul, Spiess, Christoph, Zhang, Qing

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Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets von Spiess, Christoph, Meyer, Anne S., Reissmann, Stefanie, Frydman, Judith

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TRiC's tricks inhibit huntingtin aggregation von Shahmoradian, Sarah H, Galaz-Montoya, Jesus G, Schmid, Michael F, Cong, Yao, Ma, Boxue, Spiess, Christoph, Frydman, Judith, Ludtke, Steven J, Chiu, Wah

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A Temperature-Dependent Switch from Chaperone to Protease in a Widely Conserved Heat Shock Protein von Spiess, Christoph, Beil, Alexandra, Ehrmann, Michael

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Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies von Tsai, Wen-Ting K, Li, Yinyin, Yin, Zhaojun, Tran, Peter, Phung, Qui, Zhou, Zhenru, Peng, Kun, Qin, Dan, Tam, Sien, Spiess, Christoph, Brumm, Jochen, Wong, Manda, Ye, Zhengmao, Wu, Patrick, Cohen, Sivan, Carter, Paul J

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Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells von Dillon, Michael, Yin, Yiyuan, Zhou, Jianhui, McCarty, Luke, Ellerman, Diego, Slaga, Dionysos, Junttila, Teemu T, Han, Guanghui, Sandoval, Wendy, Ovacik, Meric A, Lin, Kedan, Hu, Zhilan, Shen, Amy, Corn, Jacob E, Spiess, Christoph, Carter, Paul J

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An integrated approach for characterizing immunogenic responses toward a bispecific antibody von Cohen, Sivan, Chung, Shan, Spiess, Christoph, Lundin, Victor, Stefanich, Eric, Laing, Steven T., Clark, Vanessa, Brumm, Jochen, Zhou, Ying, Huang, Catherine, Guerrero, Joyce, Myneni, Srividya, Yadav, Rajbharan, Siradze, Ketevan, Peng, Kun

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Identification of the TRiC/CCT Substrate Binding Sites Uncovers the Function of Subunit Diversity in Eukaryotic Chaperonins von Spiess, Christoph, Miller, Erik J., McClellan, Amie J., Frydman, Judith

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MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner von Du, Changchun, Bevers, 3rd, Jack, Cook, Ryan, Lombana, T Noelle, Rajasekaran, Kamalakannan, Matsumoto, Marissa, Spiess, Christoph, Kim, Jeong M, Ye, Zhengmao

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Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent... von Yadav, Rajbharan, Sukumaran, Siddharth, Zabka, Tanja S, Li, Jinze, Oldendorp, Amy, Morrow, Gary, Reyes, Arthur, Cheu, Melissa, Li, Jessica, Wallin, Jeffrey J, Tsai, Siao, Sun, Laura, Wang, Peiyin, Ellerman, Diego, Spiess, Christoph, Polson, Andy, Stefanich, Eric G, Kamath, Amrita V, Ovacik, Meric A

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Data on charge separation of bispecific and mispaired IgGs using native charge-variant mass spectrometry von Phung, Wilson, Han, Guanghui, Polderdijk, Stéphanie G.I., Dillon, Michael, Shatz, Whitney, Liu, Peter, Wei, Bingchuan, Suresh, Pawankumar, Fischer, David, Spiess, Christoph, Bailey, Aaron, Carter, Paul J., Lill, Jennie R., Sandoval, Wendy

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Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice von Lo, Megan, Kim, Hok Seon, Tong, Raymond K., Bainbridge, Travis W., Vernes, Jean-Michel, Zhang, Yin, Lin, Yuwen Linda, Chung, Shan, Dennis, Mark S., Zuchero, Y. Joy Yu, Watts, Ryan J., Couch, Jessica A., Meng, Y. Gloria, Atwal, Jasvinder K., Brezski, Randall J., Spiess, Christoph, Ernst, James A.

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The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation von Spiess, Christoph, Joachimiak, Lukasz, Frydman, Judith, Tam, Stephen, Poirier, Michelle A, Auyeung, William, Chen, Bryan

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Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies von Spiess, Christoph, Merchant, Mark, Huang, Arthur, Zheng, Zhong, Yang, Nai-Ying, Peng, Jing, Ellerman, Diego, Shatz, Whitney, Reilly, Dorothea, Yansura, Daniel G, Scheer, Justin M

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High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry von Sawyer, William S., Srikumar, Neha, Carver, Joseph, Chu, Phillip Y., Shen, Amy, Xu, Ankai, Williams, Ambrose J., Spiess, Christoph, Wu, Cong, Liu, Yichin, Tran, John C.

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Plasma membrane damage limits cytoplasmic delivery by conventional cell penetrating peptides von Stéphanie G. I. Polderdijk, Jazeel F. Limzerwala, Christoph Spiess

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