Total synthesis of halichondrin B and norhalichondrin B von Aicher, Thomas D, Buszek, Keith R, Fang, Francis G, Forsyth, Craig J, Jung, Sun Ho, Kishi, Yoshito, Matelich, Michael C, Scola, Paul M, Spero, Denice M, Yoon, Suk Kyoon

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Highly Diastereoselective Addition of Grignard Reagents to Aliphatic, Enolizable N-Alkylketimines and 2,2-Disubstituted 1,3-Oxazolidines. Asymmetric Synthesis of the Antidepressant... von Steinig, Arno G, Spero, Denice M

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Discovery of potent and selective PKC-θ inhibitors von Cywin, Charles L., Dahmann, Georg, Prokopowicz, Anthony S., Young, Erick R.R., Magolda, Ronald L., Cardozo, Mario G., Cogan, Derek A., DiSalvo, Darren, Ginn, John D., Kashem, Mohammed A., Wolak, John P., Homon, Carol A., Farrell, Thomas M., Grbic, Heather, Hu, Hanbo, Kaplita, Paul V., Liu, Lisa H., Spero, Denice M., Jeanfavre, Deborah D., O’Shea, Kathy M., White, Della M., Woska, Joseph R., Brown, Maryanne L.

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New vaccines needed for pathogens infecting animals and humans: One Health von Gutiérrez, Andres H., Spero, Denice, Gay, Cyril, Zimic, Mirko, De Groot, Anne S.

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Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors von Ward, Yancey D, Thomson, David S, Frye, Leah L, Cywin, Charles L, Morwick, Tina, Emmanuel, Michel J, Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy, White, Della, Pav, Susan, Wang, Yong, Hao, Ming-Hong, Grygon, Christine A, Labadia, Mark E, Freeman, Dorothy M, Davidson, Walter, Hopkins, Jerry L, Brown, Maryanne L, Spero, Denice M

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Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors von Bekkali, Younes, Thomson, David S., Betageri, Raj, Emmanuel, Michel J., Hao, Ming-Hong, Hickey, Eugene, Liu, Weimin, Patel, Usha, Ward, Yancey D., Young, Erick R.R., Nelson, Richard, Kukulka, Alison, Brown, Maryanne L., Crane, Kathy, White, Della, Freeman, Dorothy M., Labadia, Mark E., Wildeson, Jessi, Spero, Denice M.

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A Novel Method for the Asymmetric Synthesis of α,α-Disubstituted Alkylamines via Grignard Additions to Ketimines von Spero, Denice M, Kapadia, Suresh R

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An orally active reversible inhibitor of cathepsin S inhibits human trans vivo delayed-type hypersensitivity von Desai, Sudha N., White, Della M., O'Shea, Kathryn M., Brown, Maryanne L., Cywin, Charles L., Spero, Denice M., Panzenbeck, Maret J.

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The design of potent hydrazones and disulfides as cathepsin S inhibitors von Cywin, Charles L, Firestone, Raymond A, McNeil, Daniel W, Grygon, Christine A, Crane, Kathryn M, White, Della M, Kinkade, Peter R, Hopkins, Jerry L, Davidson, Walter, Labadia, Mark E, Wildeson, Jessi, Morelock, Maurice M, Peterson, Jeffrey D, Raymond, Ernest L, Brown, Maryanne L, Spero, Denice M

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Enantioselective Synthesis of α,α-Disubstituted Amino Acid Derivatives via Enzymatic Resolution:  Preparation of a Thiazolyl-Substituted α-Methyl α-Benzyl Amine von Spero, Denice M, Kapadia, Suresh R

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Regiospecific control of Rh(II) carbenoids in the C-H insertion reaction von Spero, Denice M., Adams, Julian

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Enantioselective synthesis of the ( syn,anti)-1-amino-2,3-diol subunit of renin inhibitors by reaction of β-Lactams with a Grignard reagent von Spero, Denice M, Kapadia, Suresh, Farina, Vittorio

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Design and Synthesis of Dipeptide Nitriles as Reversible and Potent Cathepsin S Inhibitors von Ward, Yancey D, Thomson, David S, Frye, Leah L, Cywin, Charles L, Morwick, Tina, Emmanuel, Michel J, Zindell, Renée, McNeil, Daniel, Bekkali, Younes, Girardot, Marc, Hrapchak, Matt, DeTuri, Molly, Crane, Kathy, White, Della, Pav, Susan, Wang, Yong, Hao, Ming-Hong, Grygon, Christine A, Labadia, Mark E, Freeman, Dorothy M, Davidson, Walter, Hopkins, Jerry L, Brown, Maryanne L, Spero, Denice M

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Rhodium (II) catalyzed reactions of diazo-carbonyl compounds von Adams, Julian, Spero, Denice M.

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Benzoxazolamines and Benzothiazolamines: Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action von Lazer, Edward S, Miao, Clara K, Wong, Hin-Chor, Sorcek, Ronald, Spero, Denice M, Gilman, Alex, Pal, Kollol, Behnke, Mark, Graham, Anne G

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Intramolecular cyclopropanation-ring fragmentation leading to spirocyclic ring construction: a stereoselective synthesis of .beta.-chamigrene von Adams, Julian, Lepine-Frenette, Carole, Spero, Denice M

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Radical cyclizations in conformationally restrained systems. Generation of the cis,cis-hexahydrophenanthro[4,5-bcd]furan tetracycle of morphine von Parker, Kathlyn A, Spero, Denice M, Van Epp, James

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An Improved Synthesis of Chiral α-(4-Bromobenzyl)alanine Ethyl Ester and Its Application to the Synthesis of LFA-1 Antagonist BIRT-377 von Kapadia, Suresh R., Spero, Denice M., Eriksson, Magnus

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Evaluation of some preparations of trialkoxyphthalic acid derivatives von Parker, Kathlyn A, Spero, Denice M, Koziski, Kathleen A

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AMINES via NUCLEOPHJLIC 1,2-ADDITION TO KETIMINES. CONSTRUCTION OF NITROGEN-SUBSTITUTED QUATERNARY CARBON ATOMS. A REVIEW von Steinig, Arno G., Spero, Denice M.

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