Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy von Di Stasi, Antonio, Tey, Siok-Keen, Dotti, Gianpietro, Fujita, Yuriko, Kennedy-Nasser, Alana, Martinez, Caridad, Straathof, Karin, Liu, Enli, Liu, Hao, Durett, April G, Grilley, Bambi, Cruz, Conrad R, Savoldo, Barbara, Gee, Adrian P, Schindler, John, Krance, Robert A, Heslop, Helen E, Spencer, David M, Rooney, Cliona M, Brenner, Malcolm K

Volltext

Combining a CD20 chimeric antigen receptor and an inducible caspase 9 suicide switch to improve the efficacy and safety of T cell adoptive immunotherapy for lymphoma von Budde, Lihua E, Berger, Carolina, Lin, Yukang, Wang, Jinjuan, Lin, Xubin, Frayo, Shani E, Brouns, Shaunda A, Spencer, David M, Till, Brian G, Jensen, Michael C, Riddell, Stanley R, Press, Oliver W

Volltext

Paths of FGFR-driven tumorigenesis von Acevedo, Victor D., Ittmann, Michael, Spencer, David M.

Volltext

Notch and TGFβ Form a Reciprocal Positive Regulatory Loop that Suppresses Murine Prostate Basal Stem/Progenitor Cell Activity von Valdez, Joseph M., Zhang, Li, Su, Qingtai, Dakhova, Olga, Zhang, Yiqun, Shahi, Payam, Spencer, David M., Creighton, Chad J., Ittmann, Michael M., Xin, Li

Volltext

Inducible FGFR-1 Activation Leads to Irreversible Prostate Adenocarcinoma and an Epithelial-to-Mesenchymal Transition von Acevedo, Victor D., Gangula, Rama D., Freeman, Kevin W., Li, Rile, Zhang, Youngyou, Wang, Fen, Ayala, Gustavo E., Peterson, Leif E., Ittmann, Michael, Spencer, David M.

Volltext

A composite MyD88/CD40 switch synergistically activates mouse and human dendritic cells for enhanced antitumor efficacy von Narayanan, Priyadharshini, Lapteva, Natalia, Seethammagari, Mamatha, Levitt, Jonathan M, Slawin, Kevin M, Spencer, David M

Volltext

Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches von Duong, MyLinh T., Collinson-Pautz, Matthew R., Morschl, Eva, Lu, An, Szymanski, Slawomir P., Zhang, Ming, Brandt, Mary E., Chang, Wei-Chun, Sharp, Kelly L., Toler, Steven M., Slawin, Kevin M., Foster, Aaron E., Spencer, David M., Bayle, J. Henri

Volltext

Wnt and Notch Pathways Have Interrelated Opposing Roles on Prostate Progenitor Cell Proliferation and Differentiation von Shahi, Payam, Seethammagari, Mamatha R., Valdez, Joseph M., Xin, Li, Spencer, David M.

Volltext

Caspase-10 is an Initiator Caspase in Death Receptor Signaling von Wang, Jin, Chun, Hyung J., Wong, Wilson, Spencer, David M., Lenardo, Michael J.

Volltext

Inducible Activation of MyD88 and CD40 in CAR T Cells Results in Controllable and Potent Antitumor Activity in Preclinical Solid Tumor Models von Mata, Melinda, Gerken, Claudia, Nguyen, Phuong, Krenciute, Giedre, Spencer, David M, Gottschalk, Stephen

Volltext

MyD88/CD40 Genetic Adjuvant Function in Cutaneous Atypical Antigen-Presenting Cells Contributes to DNA Vaccine Immunogenicity von Collinson-Pautz, Matthew R, Slawin, Kevin M, Levitt, Jonathan M, Spencer, David M

Volltext

Regulated Apoptosis of Genetically Modified Hematopoietic Stem and Progenitor Cells Via an Inducible Caspase‐9 Suicide Gene in Rhesus Macaques von Barese, Cecilia N., Felizardo, Tania C., Sellers, Stephanie E., Keyvanfar, Keyvan, Di Stasi, Antonio, Metzger, Mark E., Krouse, Allen E., Donahue, Robert E., Spencer, David M., Dunbar, Cynthia E.

Volltext

Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes von Ono, Nobuyuki, Murakami, Kiichi, Chan, Olivia, Hall, Håkan, Elford, Alisha R, Yen, Patty, Calzascia, Thomas, Spencer, David M, Ohashi, Pamela S, Dhanji, Salim

Volltext

The phosphatase SRC homology region 2 domain-containing phosphatase-1 is an intrinsic central regulator of dendritic cell function von Ramachandran, Indu R, Song, Weitao, Lapteva, Natalia, Seethammagari, Mamatha, Slawin, Kevin M, Spencer, David M, Levitt, Jonathan M

Volltext

Distinct inflammatory mechanisms mediate early versus late colitis in mice von Spencer, David M., Veldman, Geertruidam M., Banerjee, Subhashis, Willis, Joseph, Levine, Alan D.

Volltext

Development of an inducible caspase-9 safety switch for pluripotent stem cell-based therapies von Wu, Chuanfeng, Hong, So Gun, Winkler, Thomas, Spencer, David M, Jares, Alexander, Ichwan, Brian, Nicolae, Alina, Guo, Vicky, Larochelle, Andre, Dunbar, Cynthia E

Volltext

Enhanced Activation of Human Dendritic Cells by Inducible CD40 and Toll-like Receptor-4 Ligation von LAPTEVA, Natalia, SEETHAMMAGARI, Mamatha R, HANKS, Brent A, JIANGHONG JIANG, LEVITT, Jonathan M, SLAWIN, Kevin M, SPENCER, David M

Volltext

Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts von Wang, Jianghua, Cai, Yi, Yu, Wendong, Ren, Chengxi, Spencer, David M, Ittmann, Michael

Volltext

Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation von Zhou, Xiaoou, Dotti, Gianpietro, Krance, Robert A., Martinez, Caridad A., Naik, Swati, Kamble, Rammurti T., Durett, April G., Dakhova, Olga, Savoldo, Barbara, Di Stasi, Antonio, Spencer, David M., Lin, Yu-Feng, Liu, Hao, Grilley, Bambi J., Gee, Adrian P., Rooney, Cliona M., Heslop, Helen E., Brenner, Malcolm K.

Volltext

Activation of antigen-exposed iMC-DCs at the "right place" and "right time" promotes potent anti-tumor immunity von Spencer, David M.

Volltext