Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing br... von WENLE XIA, GERARD, Catherine M, LEIHUA LIU, BAUDSON, Nathalie M, ORY, Thierry L, SPECTOR, Neil L

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Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways von Xia, Wenle, Mullin, Robert J, Keith, Barry R, Liu, Lei-Hua, Ma, Hong, Rusnak, David W, Owens, Gary, Alligood, Krystal J, Spector, Neil L

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Truncated ErbB2 receptor (p95 ) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR ErbB2 kinase inhibitor GW572016 von WENLE XIA, LIU, Lei-Hua, HO, Peter, SPECTOR, Neil L

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Anti-B4-blocked ricin: a phase I trial of 7-day continuous infusion in patients with B-cell neoplasms von GROSSBARD, M. L, LAMBERT, J. M, NADLER, L. M, GOLDMACHER, V. S, SPECTOR, N. L, KINSELLA, J, ELISEA, L, CORAL, F, TAYLOR, J. A, BLÄTTLER, W. A, EPSTEIN, C. L

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28-kDa Mammalian Heat Shock Protein, a Novel Substrate of a Growth Regulatory Protease Involved in Differentiation of Human Leukemia Cells (∗) von Spector, Neil L., Hardy, Lys, Ryan, Colleen, Miller, Wilson H., Humes, John L., Nadler, Lee M., Luedke, Edward

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Heat shock protein is a unique marker of growth arrest during macrophage differentiation of HL-60 cells von Spector, Neil L., Ryan, Colleen, Samson, William, Levine, Herbert, Nadler, Lee M., Arrigo, A.-P.

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Abstract PL2-1: Drug Development — Targeting HER2 beyond Trastuzumab von NL, Spector

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Growth arrest of human B lymphocytes is accompanied by induction of the low molecular weight mammalian heat shock protein (Hsp28) von Spector, NL, Samson, W, Ryan, C, Gribben, J, Urba, W, Welch, WJ, Nadler, LM

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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53 von Kurokawa, Manabu, Kim, Jiyeon, Geradts, Joseph, Matsuura, Kenkyo, Liu, Liu, Ran, Xu, Xia, Wenle, Ribar, Thomas J, Henao, Ricardo, Dewhirst, Mark W, Kim, Wun-Jae, Lucas, Joseph E, Wang, Shaomeng, Spector, Neil L, Kornbluth, Sally

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Regulation of the 28 kDa heat shock protein by retinoic acid during differentiation of human leukemic HL-60 cells von Specter, Neil Lee, Mehlen, Patrick, Ryan, Colleen, Hardy, L., Samson, William, Levine, Herbert, Nadler, Lee Marshall, Fabre, Nathalie, Arrigo, André-Patrick

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Phase I Safety, Pharmacokinetics, and Clinical Activity Study of Lapatinib (GW572016), a Reversible Dual Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinases, in Heavily... von Burris, 3rd, Howard A, Hurwitz, Herbert I, Dees, E Claire, Dowlati, Afshin, Blackwell, Kimberly L, O'Neil, Bert, Marcom, Paul K, Ellis, Matthew J, Overmoyer, Beth, Jones, Suzanne F, Harris, Jennifer L, Smith, Deborah A, Koch, Kevin M, Stead, Andrew, Mangum, Steve, Spector, Neil L

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Sensitization of tumor cells to Fas killing through overexpression of heat-shock transcription factor 1 von Xia, Wenle, Voellmy, Richard, Spector, Neil L.

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Study of the Biologic Effects of Lapatinib, a Reversible Inhibitor of ErbB1 and ErbB2 Tyrosine Kinases, on Tumor Growth and Survival Pathways in Patients With Advanced Malignancies von Spector, Neil L, Xia, Wenle, Burris, 3rd, Howard, Hurwitz, Herbert, Dees, E Claire, Dowlati, Afshin, O'Neil, Bert, Overmoyer, Beth, Marcom, Paul K, Blackwell, Kimberly L, Smith, Deborah A, Koch, Kevin M, Stead, Andrew, Mangum, Steven, Ellis, Matthew J, Liu, Leihua, Man, Albert K, Bremer, Troy M, Harris, Jennifer, Bacus, Sarah

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Truncation of Sp1 transcription factor by myeloblastin in undifferentiated HL60 cells von Rao, Jia, Zhang, Fan, Donnelly, Robert J., Spector, Neil L., Studzinski, George P.

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Activation primes human B lymphocytes to respond to heat shock von SPECTOR, N. L, FREEDMAN, A. S, FREEMAN, G, SEGIL, J, WHITMAN, J. F, WELCH, W. J, NADLER, L. M

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Regulation of survivin by ErbB2 signaling : Therapeutic implications for ErbB2-overexpressing breast cancers von WENLE XIA, BISI, John, WESTLUND, Ron E, SUMIN ZHAO, BACUS, Sarah, SPECTOR, Neil L, STRUM, Jay, LEIHUA LIU, CARRICK, Kevin, GRAHAM, Katherine M, TREECE, Amanda L, HARDWICKE, Mary Ann, DUSH, Michael, QIAOYIN LIAO

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A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon von Czito, Brian G, Hong, Timothy J, Cohen, Darrel P, Tyler, Douglas S, Lee, Catherine G, Anscher, Mitchell S, Ludwig, Kirk A, Seigler, Hilliard F, Mantyh, Christopher, Morse, Michael A, Lockhart, Albert C, Petros, William P, Honeycutt, Wanda, Spector, Neil L, Ertel, Phillip J, Mangum, Steve G, Hurwitz, Herbert I

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Tumor Selective G2/M Cell Cycle Arrest and Apoptosis of Epithelial and Hematological Malignancies by BBL22, a Benzazepine von Xia, Wenle, Spector, Sydney, Hardy, Lys, Zhao, Sumin, Saluk, Alan, Alemane, Lourdes, Spector, Neil L.

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Abstract P4-08-03: The impact of the heregulin-HER receptor signaling axis on response to HER tyrosine kinase inhibitors von Gwin, WR, Liu, L, Zhao, S, Xia, W, Spector, NL

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Activation of the AMPK regulated metabolic stress response by a small molecule HER2/EGFR tyrosine kinase inhibitor protects cardiac myocytes from apoptotic stimuli von Bacus, S. S., Hill, J. E., Trusk, P., Seger, R., Spector, N. L.

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