FATAL MYOCARDIAL INFARCTION AND THE ROLE OF ORAL CONTRACEPTIVES von KRUEGER, DEAN E., ELLENBERG, SUSAN S., BLOOM, SHERMAN, CALKINS, BEVERLY M., MALIZA, CAROL, NOLAN, DAVID C., PHILLIPS, ROLAND, RIOS, JORGE C., ROSIN, ILENE, SHEKELLE, RICHARD B., SPECTOR, KIM M., STADEL, BRUCE V., STOLLEY, PAUL D., TERRIS, MILTON

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RISK FACTORS FOR FATAL HEART ATTACK IN YOUNG WOMEN von KRUEGER, DEAN E., ELLENBERG, SUSAN S., BLOOM, SHERMAN, CALKINS, BEVERLY M., JACYNA, RITA, NOLAN, DAVID C., PHILLIPS, ROLAND, RIOS, JEORGE C., SOBIESKI, ROBERT, SHEKELLE, RICHARD B., SPECTOR, KIM M., STADEL, BRUCE V., STOLLEY, PAUL D., TERRIS, MILTON

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HLA Alleles Associated With Risk of Ankylosing Spondylitis and Rheumatoid Arthritis Influence the Gut Microbiome von Asquith, Mark, Sternes, Peter R., Costello, Mary‐Ellen, Karstens, Lisa, Diamond, Sarah, Martin, Tammy M., Li, Zhixiu, Marshall, Mhairi S., Spector, Timothy D., Cao, Kim‐Anh, Rosenbaum, James T., Brown, Matthew A.

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The mental health burden of racial and ethnic minorities during the COVID-19 pandemic von Nguyen, Long H, Anyane-Yeboa, Adjoa, Klaser, Kerstin, Merino, Jordi, Drew, David A, Ma, Wenjie, Mehta, Raaj S, Kim, Daniel Y, Warner, Erica T, Joshi, Amit D, Graham, Mark S, Sudre, Carole H, Thompson, Ellen J, May, Anna, Hu, Christina, Jørgensen, Solveig, Selvachandran, Somesh, Berry, Sarah E, David, Sean P, Martinez, Maria Elena, Figueiredo, Jane C, Murray, Anne M, Sanders, Alan R, Koenen, Karestan C, Wolf, Jonathan, Ourselin, Sebastien, Spector, Tim D, Steves, Claire J, Chan, Andrew T

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Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine von Baden, Lindsey R, El Sahly, Hana M, Essink, Brandon, Kotloff, Karen, Frey, Sharon, Novak, Rick, Diemert, David, Spector, Stephen A, Rouphael, Nadine, Creech, C. Buddy, McGettigan, John, Khetan, Shishir, Segall, Nathan, Solis, Joel, Brosz, Adam, Fierro, Carlos, Schwartz, Howard, Neuzil, Kathleen, Corey, Larry, Gilbert, Peter, Janes, Holly, Follmann, Dean, Marovich, Mary, Mascola, John, Polakowski, Laura, Ledgerwood, Julie, Graham, Barney S, Bennett, Hamilton, Pajon, Rolando, Knightly, Conor, Leav, Brett, Deng, Weiping, Zhou, Honghong, Han, Shu, Ivarsson, Melanie, Miller, Jacqueline, Zaks, Tal

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Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer von Cheng, Qing, Chang, Jeffrey T, Geradts, Joseph, Neckers, Leonard M, Haystead, Timothy, Spector, Neil L, Lyerly, H Kim

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Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data von Powell, Joseph E, Henders, Anjali K, McRae, Allan F, Kim, Jinhee, Hemani, Gibran, Martin, Nicholas G, Dermitzakis, Emmanouil T, Gibson, Greg, Montgomery, Grant W, Visscher, Peter M

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A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging von McCormick, Mark A., Delaney, Joe R., Tsuchiya, Mitsuhiro, Tsuchiyama, Scott, Shemorry, Anna, Sim, Sylvia, Chou, Annie Chia-Zong, Ahmed, Umema, Carr, Daniel, Murakami, Christopher J., Schleit, Jennifer, Sutphin, George L., Wasko, Brian M., Bennett, Christopher F., Wang, Adrienne M., Olsen, Brady, Beyer, Richard P., Bammler, Theodor K., Prunkard, Donna, Johnson, Simon C., Pennypacker, Juniper K., An, Elroy, Anies, Arieanna, Castanza, Anthony S., Choi, Eunice, Dang, Nick, Enerio, Shiena, Fletcher, Marissa, Fox, Lindsay, Goswami, Sarani, Higgins, Sean A., Holmberg, Molly A., Hu, Di, Hui, Jessica, Jelic, Monika, Jeong, Ki-Soo, Johnston, Elijah, Kerr, Emily O., Kim, Jin, Kim, Diana, Kirkland, Katie, Klum, Shannon, Kotireddy, Soumya, Liao, Eric, Lim, Michael, Lin, Michael S., Lo, Winston C., Lockshon, Dan, Miller, Hillary A., Moller, Richard M., Muller, Brian, Oakes, Jonathan, Pak, Diana N., Peng, Zhao Jun, Pham, Kim M., Pollard, Tom G., Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Robison, Brett, Rodriguez, Ariana A., Ros, Bopharoth, Sage, Michael, Singh, Manpreet K., Smith, Erica D., Snead, Katie, Solanky, Amrita, Spector, Benjamin L., Steffen, Kristan K., Tchao, Bie Nga, Ting, Marc K., Vander Wende, Helen, Wang, Dennis, Welton, K. Linnea, Westman, Eric A., Brem, Rachel B., Liu, Xin-guang, Suh, Yousin, Zhou, Zhongjun, Kaeberlein, Matt, Kennedy, Brian K.

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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53 von Kurokawa, Manabu, Kim, Jiyeon, Geradts, Joseph, Matsuura, Kenkyo, Liu, Liu, Ran, Xu, Xia, Wenle, Ribar, Thomas J, Henao, Ricardo, Dewhirst, Mark W, Kim, Wun-Jae, Lucas, Joseph E, Wang, Shaomeng, Spector, Neil L, Kornbluth, Sally

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The mutational constraint spectrum quantified from variation in 141,456 humans von Karczewski, Konrad J., Francioli, Laurent C., Tiao, Grace, Cummings, Beryl B., Alföldi, Jessica, Wang, Qingbo, Collins, Ryan L., Laricchia, Kristen M., Ganna, Andrea, Birnbaum, Daniel P., Gauthier, Laura D., Brand, Harrison, Solomonson, Matthew, Watts, Nicholas A., Rhodes, Daniel, Singer-Berk, Moriel, England, Eleina M., Seaby, Eleanor G., Kosmicki, Jack A., Walters, Raymond K., Tashman, Katherine, Farjoun, Yossi, Banks, Eric, Poterba, Timothy, Wang, Arcturus, Seed, Cotton, Whiffin, Nicola, Chong, Jessica X., Samocha, Kaitlin E., Pierce-Hoffman, Emma, Zappala, Zachary, O’Donnell-Luria, Anne H., Minikel, Eric Vallabh, Weisburd, Ben, Lek, Monkol, Ware, James S., Vittal, Christopher, Armean, Irina M., Bergelson, Louis, Cibulskis, Kristian, Connolly, Kristen M., Covarrubias, Miguel, Donnelly, Stacey, Ferriera, Steven, Gabriel, Stacey, Gentry, Jeff, Gupta, Namrata, Jeandet, Thibault, Kaplan, Diane, Llanwarne, Christopher, Munshi, Ruchi, Novod, Sam, Petrillo, Nikelle, Roazen, David, Ruano-Rubio, Valentin, Saltzman, Andrea, Schleicher, Molly, Soto, Jose, Tibbetts, Kathleen, Tolonen, Charlotte, Wade, Gordon, Talkowski, Michael E., Neale, Benjamin M., Daly, Mark J., MacArthur, Daniel G.

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A structural variation reference for medical and population genetics von Collins, Ryan L., Brand, Harrison, Karczewski, Konrad J., Zhao, Xuefang, Alföldi, Jessica, Francioli, Laurent C., Khera, Amit V., Lowther, Chelsea, Gauthier, Laura D., Wang, Harold, Watts, Nicholas A., Solomonson, Matthew, O’Donnell-Luria, Anne, Baumann, Alexander, Munshi, Ruchi, Walker, Mark, Whelan, Christopher W., Huang, Yongqing, Brookings, Ted, Sharpe, Ted, Stone, Matthew R., Valkanas, Elise, Fu, Jack, Tiao, Grace, Laricchia, Kristen M., Ruano-Rubio, Valentin, Stevens, Christine, Gupta, Namrata, Cusick, Caroline, Margolin, Lauren, Taylor, Kent D., Lin, Henry J., Rich, Stephen S., Post, Wendy S., Chen, Yii-Der Ida, Rotter, Jerome I., Nusbaum, Chad, Philippakis, Anthony, Lander, Eric, Gabriel, Stacey, Neale, Benjamin M., Kathiresan, Sekar, Daly, Mark J., Banks, Eric, MacArthur, Daniel G., Talkowski, Michael E.

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Transcript expression-aware annotation improves rare variant interpretation von Cummings, Beryl B., Karczewski, Konrad J., Kosmicki, Jack A., Seaby, Eleanor G., Watts, Nicholas A., Singer-Berk, Moriel, Mudge, Jonathan M., Karjalainen, Juha, Satterstrom, F. Kyle, O’Donnell-Luria, Anne H., Poterba, Timothy, Seed, Cotton, Solomonson, Matthew, Alföldi, Jessica, Daly, Mark J., MacArthur, Daniel G.

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Molecular mechanisms underlying genotype‐dependent responses to dietary restriction von Schleit, Jennifer, Johnson, Simon C., Bennett, Christopher F., Simko, Marissa, Trongtham, Natalie, Castanza, Anthony, Hsieh, Edward J., Moller, Richard M., Wasko, Brian M., Delaney, Joe R., Sutphin, George L., Carr, Daniel, Murakami, Christopher J., Tocchi, Autumn, Xian, Bo, Chen, Weiyang, Yu, Tao, Goswami, Sarani, Higgins, Sean, Holmberg, Mollie, Jeong, Ki‐Soo, Kim, Jin R., Klum, Shannon, Liao, Eric, Lin, Michael S., Lo, Winston, Miller, Hillary, Olsen, Brady, Peng, Zhao J., Pollard, Tom, Pradeep, Prarthana, Pruett, Dillon, Rai, Dilreet, Ros, Vanessa, Singh, Minnie, Spector, Benjamin L., Wende, Helen Vander, An, Elroy H., Fletcher, Marissa, Jelic, Monika, Rabinovitch, Peter S., MacCoss, Michael J., Han, Jing‐Dong J., Kennedy, Brian K., Kaeberlein, Matt

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Evaluating drug targets through human loss-of-function genetic variation von Minikel, Eric Vallabh, Karczewski, Konrad J., Martin, Hilary C., Cummings, Beryl B., Whiffin, Nicola, Rhodes, Daniel, Alföldi, Jessica, Trembath, Richard C., van Heel, David A., Daly, Mark J., Schreiber, Stuart L., MacArthur, Daniel G.

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Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries von Piperni, Elisa, Nguyen, Long H., Manghi, Paolo, Kim, Hanseul, Pasolli, Edoardo, Andreu-Sánchez, Sergio, Arrè, Alberto, Bermingham, Kate M., Blanco-Míguez, Aitor, Manara, Serena, Valles-Colomer, Mireia, Bakker, Elco, Busonero, Fabio, Davies, Richard, Fiorillo, Edoardo, Giordano, Francesca, Hadjigeorgiou, George, Leeming, Emily R., Lobina, Monia, Masala, Marco, Maschio, Andrea, McIver, Lauren J., Pala, Mauro, Pitzalis, Maristella, Wolf, Jonathan, Fu, Jingyuan, Zhernakova, Alexandra, Cacciò, Simone M., Cucca, Francesco, Berry, Sarah E., Ercolini, Danilo, Chan, Andrew T., Huttenhower, Curtis, Spector, Tim D., Segata, Nicola, Asnicar, Francesco

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Development and validation of a clinical prediction-score model for distant metastases in major salivary gland carcinoma von Lukovic, J., Alfaraj, F.A., Mierzwa, M.L., Marta, G.N., Xu, W., Su, J., Moraes, F.Y., Huang, S.H., Bratman, S.V., O’Sullivan, B., Kim, J.J., Ringash, J.G., Waldron, J., de Almeida, J.R., Goldstein, D.P., Casper, K.A., Rosko, A.J., Spector, M.E., Kowalski, L.P., Hope, A., Hosni, A.

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Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer von Wu, Chunjing, Spector, Sydney A, Theodoropoulos, George, Nguyen, Dan J M, Kim, Emily Y, Garcia, Ashley, Savaraj, Niramol, Lim, Diane C, Paul, Ankita, Feun, Lynn G, Bickerdike, Michael, Wangpaichitr, Medhi

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Telemedicine‐enabled biofeedback electropalatography rehabilitation (TEBER): A pilot study for patients treated with surgery for oral cavity carcinoma von Chepeha, Douglas B., Barbon, Carly E. A., Esemezie, Alex O., Al Mardini, Majd, Philteos, Justine, Spector, Matthew E., Bressmann, Tim, Martino, Rosemary, Bratman, Scott V., Cho, John B. C., Hope, Andrew J., Hosni, Ali Abdalati, Kim, John J. H., Ringash, Jolie G., Waldron, John N., Brown, Dale H., Almeida, John R., Gilbert, Ralph W., Goldstein, David P., Gullane, Patrick J., Irish, Jonathan C., Monteiro, Eric A., Yao, Christopher M. K. L.

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Landscape of multi-nucleotide variants in 125,748 human exomes and 15,708 genomes von Wang, Qingbo, Pierce-Hoffman, Emma, Cummings, Beryl B., Alföldi, Jessica, Francioli, Laurent C., Gauthier, Laura D., Hill, Andrew J., O’Donnell-Luria, Anne H., Karczewski, Konrad J., MacArthur, Daniel G.

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Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative von Wang, Jun, Kurilshikov, Alexander, Radjabzadeh, Djawad, Turpin, Williams, Croitoru, Kenneth, Bonder, Marc Jan, Jackson, Matthew A, Medina-Gomez, Carolina, Frost, Fabian, Homuth, Georg, Rühlemann, Malte, Hughes, David, Kim, Han-Na, Spector, Tim D, Bell, Jordana T, Steves, Claire J, Timpson, Nicolas, Franke, Andre, Wijmenga, Cisca, Meyer, Katie, Kacprowski, Tim, Franke, Lude, Paterson, Andrew D, Raes, Jeroen, Kraaij, Robert, Zhernakova, Alexandra

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