Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis von Linsley, Peter S, Speake, Cate, Whalen, Elizabeth, Chaussabel, Damien

Volltext

Citrullination of glucokinase is linked to autoimmune diabetes von Yang, Mei-Ling, Horstman, Sheryl, Gee, Renelle, Guyer, Perrin, Lam, TuKiet T., Kanyo, Jean, Perdigoto, Ana L., Speake, Cate, Greenbaum, Carla J., Callebaut, Aïsha, Overbergh, Lut, Kibbey, Richard G., Herold, Kevan C., James, Eddie A., Mamula, Mark J.

Volltext

A standardized metric to enhance clinical trial design and outcome interpretation in type 1 diabetes von Ylescupidez, Alyssa, Bahnson, Henry T., O’Rourke, Colin, Lord, Sandra, Speake, Cate, Greenbaum, Carla J.

Volltext

Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes von Abdelsamed, Hossam A., Zebley, Caitlin C., Nguyen, Hai, Rutishauser, Rachel L., Fan, Yiping, Ghoneim, Hazem E., Crawford, Jeremy Chase, Alfei, Francesca, Alli, Shanta, Ribeiro, Susan Pereira, Castellaw, Ashley H., McGargill, Maureen A., Jin, Hongjian, Boi, Shannon K., Speake, Cate, Serti, Elisavet, Turka, Laurence A., Busch, Michael E., Stone, Mars, Deeks, Steven G., Sekaly, Rafick-Pierre, Zehn, Dietmar, James, Eddie A., Nepom, Gerald T., Youngblood, Ben

Volltext

Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas von Linsley, Peter S., Nakayama, Maki, Balmas, Elisa, Chen, Janice, Barahmand-pour-Whitman, Fariba, Bansal, Shubham, Bottorff, Ty, Serti, Elisavet, Speake, Cate, Pugliese, Alberto, Cerosaletti, Karen

Volltext

SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity von Jaycox, Jillian R., Lucas, Carolina, Yildirim, Inci, Dai, Yile, Wang, Eric Y., Monteiro, Valter, Lord, Sandra, Carlin, Jeffrey, Kita, Mariko, Buckner, Jane H., Ma, Shuangge, Campbell, Melissa, Ko, Albert, Omer, Saad, Lucas, Carrie L., Speake, Cate, Iwasaki, Akiko, Ring, Aaron M.

Volltext

Testing a new platform to screen disease-modifying therapy in type 1 diabetes von Lord, Sandra M, Bahnson, Henry T, Greenbaum, Carla J, Liljenquist, David R, Virostko, John, Speake, Cate

Volltext

Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes von Rodrigues, Kameron B., Dufort, Matthew J., Llibre, Alba, Speake, Cate, Rahman, M. Jubayer, Bondet, Vincent, Quiel, Juan, Linsley, Peter S., Greenbaum, Carla J., Duffy, Darragh, Tarbell, Kristin V.

Volltext

Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis von Shapiro, Melanie R., Wasserfall, Clive H., McGrail, Sean M., Posgai, Amanda L., Bacher, Rhonda, Muir, Andrew, Haller, Michael J., Schatz, Desmond A., Wesley, Johnna D., von Herrath, Matthias, Hagopian, William A., Speake, Cate, Atkinson, Mark A., Brusko, Todd M.

Volltext

The Relationship of Immune Cell Signatures to Patient Survival Varies within and between Tumor Types von Linsley, Peter S, Chaussabel, Damien, Speake, Cate

Volltext

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4 + T Cells in Peripheral Blood of Subjects with Type 1 Diabetes von Cerosaletti, Karen, Barahmand-Pour-Whitman, Fariba, Yang, Junbao, DeBerg, Hannah A, Dufort, Matthew J, Murray, Sara A, Israelsson, Elisabeth, Speake, Cate, Gersuk, Vivian H, Eddy, James A, Reijonen, Helena, Greenbaum, Carla J, Kwok, William W, Wambre, Erik, Prlic, Martin, Gottardo, Raphael, Nepom, Gerald T, Linsley, Peter S

Volltext

Mediators of monocyte chemotaxis and matrix remodeling are associated with mortality and pulmonary fibroproliferation in patients with severe COVID-19 von Holton, Sarah E, Mitchem, Mallorie, Chalian, Hamid, Pipavath, Sudhakar, Morrell, Eric D, Bhatraju, Pavan K, Hamerman, Jessica A, Speake, Cate, Malhotra, Uma, Wurfel, Mark M, Ziegler, Steven E, Mikacenic, Carmen

Volltext

Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR von Cortez, Felipe de Jesus, Gebhart, David, Robinson, Peter V., Seftel, David, Pourmandi, Narges, Owyoung, Jordan, Bertozzi, Carolyn R., Wilson, Darrell M., Maahs, David M., Buckingham, Bruce A., Mills, John R., Roforth, Matthew M., Pittock, Sean J., McKeon, Andrew, Page, Kara, Wolf, Wendy A., Sanda, Srinath, Speake, Cate, Greenbaum, Carla J., Tsai, Cheng-ting

Volltext

The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes von Greaney, Allison J, Eguia, Rachel T, Starr, Tyler N, Khan, Khadija, Franko, Nicholas, Logue, Jennifer K, Lord, Sandra M, Speake, Cate, Chu, Helen Y, Sigal, Alex, Bloom, Jesse D

Volltext

Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes von Yang, Junbao, Wen, Xiaomin, Xu, Hengyu, Torres-Chinn, Nadia, Speake, Cate, Greenbaum, Carla J, Nepom, Gerald T, Kwok, William W

Volltext

Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates von Bogdani, Marika, Speake, Cate, Dufort, Mathew J., Johnson, Pamela Y., Larmore, Megan J., Day, Anthony J., Wight, Thomas N., Lernmark, Åke, Greenbaum, Carla J.

Volltext

Characterizing T cell responses to enzymatically modified beta cell neo-epitopes von Nguyen, Hai, Arribas-Layton, David, Chow, I-Ting, Speake, Cate, Kwok, William W, Hessner, Martin J, Greenbaum, Carla J, James, Eddie A

Volltext

Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles von Long, Sarah Alice, Muir, Virginia S, Jones, Britta E, Wall, Valerie Z, Ylescupidez, Alyssa, Hocking, Anne M, Pribitzer, Stephan, Thorpe, Jerill, Fuchs, Bryce, Wiedeman, Alice E, Tatum, Megan, Lambert, Katharina, Uchtenhagen, Hannes, Speake, Cate, Ng, Bernard, Heubeck, Alexander T, Torgerson, Troy R, Savage, Adam K, Maldonado, Michael A, Ray, Neelanjana, Khaychuk, Vadim, Liu, Jinqi, Linsley, Peter S, Buckner, Jane H

Volltext

Diminished responses to mRNA-based SARS-CoV-2 vaccines in individuals with rheumatoid arthritis on immune modifying therapies von Klebanoff, Samuel D, Rodda, Lauren B, Morishima, Chihiro, Wener, Mark H, Yuzefpolskiy, Yevgeniy, Bettelli, Estelle, Buckner, Jane H, Speake, Cate, Pepper, Marion, Campbell, Daniel J

Volltext

Islet-autoreactive CD4+ T cells are linked with response to alefacept in type 1 diabetes von Balmas, Elisa, Chen, Janice, Hu, Alex K, DeBerg, Hannah A, Rosasco, Mario G, Gersuk, Vivian H, Serti, Elisavet, Speake, Cate, Greenbaum, Carla J, Nepom, Gerald T, Linsley, Peter S, Cerosaletti, Karen

Volltext