Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents von Xiao, Zhan, Chen, Zehan, Gunasekera, Angelo H., Sowin, Thomas J., Rosenberg, Saul H., Fesik, Steve, Zhang, Haiying

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Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase–activated protein kinase 2 in mediating DNA damage–induced cell cycle arrest: i... von Xiao, Zhan, Xue, John, Sowin, Thomas J, Zhang, Haiying

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Selective Chk1 inhibitors differentially sensitize p53‐deficient cancer cells to cancer therapeutics von Chen, Zehan, Xiao, Zhan, Gu, Wen‐zhen, Xue, John, Bui, Mai H., Kovar, Peter, Li, Gaoquan, Wang, Gary, Tao, Zhi‐Fu, Tong, Yunsong, Lin, Nan‐Horng, Sham, Hing L., Wang, Jean Y. J., Sowin, Thomas J., Rosenberg, Saul H., Zhang, Haiying

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A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation von Xiao, Zhan, Xue, John, Sowin, Thomas J, Rosenberg, Saul H, Zhang, Haiying

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Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors von Wang, Le, Sullivan, Gerard M, Hexamer, Laura A, Hasvold, Lisa A, Thalji, Reema, Przytulinska, Magdalena, Tao, Zhi-Fu, Li, Gaoquan, Chen, Zehan, Xiao, Zhan, Gu, Wen-Zhen, Xue, John, Bui, Mai-Ha, Merta, Philip, Kovar, Peter, Bouska, Jennifer J, Zhang, Haiying, Park, Chang, Stewart, Kent D, Sham, Hing L, Sowin, Thomas J, Rosenberg, Saul H, Lin, Nan-Horng

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Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics von Xiao, Zhan, Xue, John, Semizarov, Dimitri, Sowin, Thomas J., Rosenberg, Saul H., Zhang, Haiying

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Discovery of 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1... von Tao, Zhi-Fu, Li, Gaoquan, Tong, Yunsong, Stewart, Kent D., Chen, Zehan, Bui, Mai-Ha, Merta, Philip, Park, Chang, Kovar, Peter, Zhang, Haiying, Sham, Hing L., Rosenberg, Saul H., Sowin, Thomas J., Lin, Nan-Horng

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Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors von Tao, Zhi-Fu, Li, Gaoquan, Tong, Yunsong, Chen, Zehan, Merta, Philip, Kovar, Peter, Zhang, Haiying, Rosenberg, Saul H., Sham, Hing L., Sowin, Thomas J., Lin, Nan-Horng

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Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Molone... von Tao, Zhi-Fu, Hasvold, Lisa A, Leverson, Joel D, Han, Edward K, Guan, Ran, Johnson, Eric F, Stoll, Vincent S, Stewart, Kent D, Stamper, Geoff, Soni, Nirupama, Bouska, Jennifer J, Luo, Yan, Sowin, Thomas J, Lin, Nan-Horng, Giranda, Vincent S, Rosenberg, Saul H, Penning, Thomas D

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Isoxazolo[3,4- b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: Chemistry, biological activities, and molecular modeling von Tong, Yunsong, Stewart, Kent D., Thomas, Sheela, Przytulinska, Magdalena, Johnson, Eric F., Klinghofer, Vered, Leverson, Joel, McCall, Owen, Soni, Niru B., Luo, Yan, Lin, Nan-horng, Sowin, Thomas J., Giranda, Vincent L., Penning, Thomas D.

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Synthesis of Substituted Quinolines Using the Dianion Addition of N-Boc-anilines and α-Tolylsulfonyl-α,β-unsaturated Ketones von Swenson, Rolf E, Sowin, Thomas J, Zhang, Henry Q

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Discovery of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors von Tong, Yunsong, Claiborne, Akiyo, Stewart, Kent D., Park, Chang, Kovar, Peter, Chen, Zehan, Credo, Robert B., Gu, Wen-Zhen, Gwaltney, Stephen L., Judge, Russell A., Zhang, Haiying, Rosenberg, Saul H., Sham, Hing L., Sowin, Thomas J., Lin, Nan-horng

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1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel von Dinges, Jürgen, Albert, Daniel H, Arnold, Lee D, Ashworth, Kimba L, Akritopoulou-Zanze, Irini, Bousquet, Peter F, Bouska, Jennifer J, Cunha, George A, Davidsen, Steven K, Diaz, Gilbert J, Djuric, Stevan W, Gasiecki, Alan F, Gintant, Gary A, Gracias, Vijaya J, Harris, Christopher M, Houseman, Kathryn A, Hutchins, Charles W, Johnson, Eric F, Li, Hu, Marcotte, Patrick A, Martin, Ruth L, Michaelides, Michael R, Nyein, Michelle, Sowin, Thomas J, Su, Zhi, Tapang, Paul H, Xia, Zhiren, Zhang, Henry Q

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Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors von Xiao, Zhan, Xue, John, Gu, Wen-Zhen, Bui, Mai, Li, Gaoquan, Tao, Zhi-Fu, Lin, Nan-Horng, Sowin, Thomas J., Zhang, Haiying

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Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[ b, e][1,4]diazepin-11-ones as potent Chk1 inhibitors von Hasvold, Lisa A., Wang, Le, Przytulinska, Magdalena, Xiao, Zhan, Chen, Zehan, Gu, Wen-Zhen, Merta, Philip J., Xue, John, Kovar, Peter, Zhang, Haiying, Park, Chang, Sowin, Thomas J., Rosenberg, Saul H., Lin, Nan-Horng

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Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2- c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors von Akritopoulou-Zanze, Irini, Albert, Daniel H., Bousquet, Peter F., Cunha, George A., Harris, Christopher M., Moskey, Maria, Dinges, Jurgen, Stewart, Kent D., Sowin, Thomas J.

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Hit-to-lead optimization of 1,4-dihydroindeno[1,2- c]pyrazoles as a novel class of KDR kinase inhibitors von Dinges, Jürgen, Akritopoulou-Zanze, Irini, Arnold, Lee D., Barlozzari, Teresa, Bousquet, Peter F., Cunha, George A., Ericsson, Anna M., Iwasaki, Nobuhiko, Michaelides, Michael R., Ogawa, Nobuo, Phelan, Kathleen M., Rafferty, Paul, Sowin, Thomas J., Stewart, Kent D., Tokuyama, Ryukou, Xia, Zhiren, Zhang, Henry Q.

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1,4-Dihydroindeno[1,2- c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors von Dinges, Jürgen, Ashworth, Kimba L., Akritopolou-Zanze, Irini, Arnold, Lee D., Baumeister, Steven A., Bousquet, Peter F., Cunha, George A., Davidsen, Steven K., Djuric, Stevan W., Gracias, Vijaya J., Michaelides, Michael R., Rafferty, Paul, Sowin, Thomas J., Stewart, Kent D., Xia, Zhiren, Zhang, Henry Q.

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1,4-Dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Extended exploration on phenyl ring substitutions and preliminary ADME/PK studies von Tong, Yunsong, Claiborne, Akiyo, Pyzytulinska, Magdalena, Tao, Zhi-Fu, Stewart, Kent D., Kovar, Peter, Chen, Zehan, Credo, Robert B., Guan, Ran, Merta, Philip J., Zhang, Haiying, Bouska, Jennifer, Everitt, Elizabeth A., Murry, Bernard P., Hickman, Dean, Stratton, Tim J., Wu, Jian, Rosenberg, Saul H., Sham, Hing L., Sowin, Thomas J., Lin, Nan-horng

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Cyanopyridyl containing 1,4-dihydroindeno[1,2- c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability von Tong, Yunsong, Przytulinska, Magdalena, Tao, Zhi-Fu, Bouska, Jennifer, Stewart, Kent D., Park, Chang, Li, Gaoquan, Claiborne, Akiyo, Kovar, Peter, Chen, Zehan, Merta, Philip J., Bui, Mai-Ha, Olson, Amanda, Osterling, Donald, Zhang, Haiying, Sham, Hing L., Rosenberg, Saul H., Sowin, Thomas J., Lin, Nan-horng

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