Whole-genome sequencing analysis of the cardiometabolic proteome von Gilly, Arthur, Park, Young-Chan, Png, Grace, Barysenka, Andrei, Fischer, Iris, Bjørnland, Thea, Southam, Lorraine, Suveges, Daniel, Neumeyer, Sonja, Rayner, N. William, Tsafantakis, Emmanouil, Karaleftheri, Maria, Dedoussis, George, Zeggini, Eleftheria

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Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits von Southam, Lorraine, Gilly, Arthur, Süveges, Dániel, Farmaki, Aliki-Eleni, Schwartzentruber, Jeremy, Tachmazidou, Ioanna, Matchan, Angela, Rayner, Nigel W., Tsafantakis, Emmanouil, Karaleftheri, Maria, Xue, Yali, Dedoussis, George, Zeggini, Eleftheria

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A molecular quantitative trait locus map for osteoarthritis von Steinberg, Julia, Southam, Lorraine, Roumeliotis, Theodoros I., Clark, Matthew J., Jayasuriya, Raveen L., Swift, Diane, Shah, Karan M., Butterfield, Natalie C., Brooks, Roger A., McCaskie, Andrew W., Bassett, J. H. Duncan, Williams, Graham R., Choudhary, Jyoti S., Wilkinson, J. Mark, Zeggini, Eleftheria

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A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis von Ng, Michael, Thakkar, Dipti, Southam, Lorraine, Werker, Paul, Ophoff, Roel, Becker, Kerstin, Nothnagel, Michael, Franke, Andre, Nürnberg, Peter, Espirito-Santo, Ana Isabel, Izadi, David, Hennies, Hans Christian, Nanchahal, Jagdeep, Zeggini, Eleftheria, Furniss, Dominic

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Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations von Xue, Yali, Mezzavilla, Massimo, Haber, Marc, McCarthy, Shane, Chen, Yuan, Narasimhan, Vagheesh, Gilly, Arthur, Ayub, Qasim, Colonna, Vincenza, Southam, Lorraine, Finan, Christopher, Massaia, Andrea, Chheda, Himanshu, Palta, Priit, Ritchie, Graham, Asimit, Jennifer, Dedoussis, George, Gasparini, Paolo, Palotie, Aarno, Ripatti, Samuli, Soranzo, Nicole, Toniolo, Daniela, Wilson, James F., Durbin, Richard, Tyler-Smith, Chris, Zeggini, Eleftheria

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Functional Variants within the Secreted Frizzled-Related Protein 3 Gene Are Associated with Hip Osteoarthritis in Females von Loughlin, John, Dowling, Barbara, Chapman, Kay, Marcelline, Lucy, Mustafa, Zehra, Southam, Lorraine, Ferreira, Athena, Ciesielski, Cathleen, Carson, Dennis A., Corr, Maripat

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Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations von Kuchenbaecker, Karoline, Gilly, Arthur, Suveges, Daniel, Southam, Lorraine, Giannakopoulou, Olga, Kilian, Britt, Tsafantakis, Emmanouil, Karaleftheri, Maria, Farmaki, Aliki-Eleni, Gurdasani, Deepti, Kundu, Kousik, Sandhu, Manjinder S., Danesh, John, Butterworth, Adam, Barroso, Inês, Dedoussis, George, Zeggini, Eleftheria

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Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits von Gilly, Arthur, Suveges, Daniel, Kuchenbaecker, Karoline, Pollard, Martin, Southam, Lorraine, Hatzikotoulas, Konstantinos, Farmaki, Aliki-Eleni, Bjornland, Thea, Waples, Ryan, Appel, Emil V. R., Casalone, Elisabetta, Melloni, Giorgio, Kilian, Britt, Rayner, Nigel W., Ntalla, Ioanna, Kundu, Kousik, Walter, Klaudia, Danesh, John, Butterworth, Adam, Barroso, Inês, Tsafantakis, Emmanouil, Dedoussis, George, Moltke, Ida, Zeggini, Eleftheria

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A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates von Tachmazidou, Ioanna, Dedoussis, George, Southam, Lorraine, Farmaki, Aliki-Eleni, Ritchie, Graham R. S., Xifara, Dionysia K., Matchan, Angela, Hatzikotoulas, Konstantinos, Rayner, Nigel W., Chen, Yuan, Pollin, Toni I., O’Connell, Jeffrey R., Yerges-Armstrong, Laura M., Kiagiadaki, Chrysoula, Panoutsopoulou, Kalliope, Schwartzentruber, Jeremy, Moutsianas, Loukas, Tsafantakis, Emmanouil, Tyler-Smith, Chris, McVean, Gil, Xue, Yali, Zeggini, Eleftheria

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Evaluating the glucose raising effect of established loci via a genetic risk score von Marouli, Eirini, Kanoni, Stavroula, Mamakou, Vasiliki, Hackinger, Sophie, Southam, Lorraine, Prins, Bram, Rentari, Angela, Dimitriou, Maria, Zengini, Eleni, Gonidakis, Fragiskos, Kolovou, Genovefa, Kontaxakis, Vassilis, Rallidis, Loukianos, Tentolouris, Nikolaos, Thanopoulou, Anastasia, Lamnissou, Klea, Dedoussis, George, Zeggini, Eleftheria, Deloukas, Panagiotis

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Author Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits von Gilly, Arthur, Suveges, Daniel, Kuchenbaecker, Karoline, Pollard, Martin, Southam, Lorraine, Hatzikotoulas, Konstantinos, Farmaki, Aliki-Eleni, Bjornland, Thea, Waples, Ryan, Appel, Emil V. R., Casalone, Elisabetta, Melloni, Giorgio, Kilian, Britt, Rayner, Nigel W., Ntalla, Ioanna, Kundu, Kousik, Walter, Klaudia, Danesh, John, Butterworth, Adam, Barroso, Inês, Tsafantakis, Emmanouil, Dedoussis, George, Moltke, Ida, Zeggini, Eleftheria

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Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study von Mamakou, Vasiliki, Hackinger, Sophie, Zengini, Eleni, Tsompanaki, Evgenia, Marouli, Eirini, Serafetinidis, Ioannis, Prins, Bram, Karabela, Athina, Glezou, Eirini, Southam, Lorraine, Rayner, Nigel W, Kuchenbaecker, Karoline, Lamnissou, Klea, Kontaxakis, Vassilis, Dedoussis, George, Gonidakis, Fragiskos, Thanopoulou, Anastasia, Tentolouris, Nikolaos, Zeggini, Eleftheria

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Genome-wide Association Scan Identifies a Prostaglandin-Endoperoxide Synthase 2 Variant Involved in Risk of Knee Osteoarthritis von Valdes, Ana M., Loughlin, John, Timms, Kirsten M., van Meurs, Joyce J.B., Southam, Lorraine, Wilson, Scott G., Doherty, Sally, Lories, Rik J., Luyten, Frank P., Gutin, Alexander, Abkevich, Victor, Ge, Dongliang, Hofman, Albert, Uitterlinden, André G., Hart, Deborah J., Zhang, Feng, Zhai, Guangju, Egli, Rainer J., Doherty, Michael, Lanchbury, Jerry, Spector, Tim D.

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Association of a functional microsatellite within intron 1 of the BMP5 gene with susceptibility to osteoarthritis von Wilkins, James M, Southam, Lorraine, Mustafa, Zehra, Chapman, Kay, Loughlin, John

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Variation in the secreted frizzled-related protein-3 gene and risk of Osteolysis and heterotopic ossification after total hip arthroplasty von Gordon, Andrew, Southam, Lorraine, Loughlin, John, Wilson, Anthony Gerard, Stockley, Ian, Hamer, Andrew J., Eastell, Richard, Wilkinson, Jeremy Mark

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Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data von Tachmazidou, Ioanna, Hatzikotoulas, Konstantinos, Southam, Lorraine, Esparza-Gordillo, Jorge, Haberland, Valeriia, Zheng, Jie, Johnson, Toby, Koprulu, Mine, Zengini, Eleni, Steinberg, Julia, Wilkinson, Jeremy M., Bhatnagar, Sahir, Hoffman, Joshua D., Buchan, Natalie, Süveges, Dániel, Yerges-Armstrong, Laura, Smith, George Davey, Gaunt, Tom R., Scott, Robert A., McCarthy, Linda C., Zeggini, Eleftheria

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Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis von Zengini, Eleni, Hatzikotoulas, Konstantinos, Tachmazidou, Ioanna, Steinberg, Julia, Hartwig, Fernando P., Southam, Lorraine, Hackinger, Sophie, Boer, Cindy G., Styrkarsdottir, Unnur, Gilly, Arthur, Suveges, Daniel, Killian, Britt, Ingvarsson, Thorvaldur, Jonsson, Helgi, Babis, George C., McCaskie, Andrew, Uitterlinden, Andre G., van Meurs, Joyce B. J., Thorsteinsdottir, Unnur, Stefansson, Kari, Davey Smith, George, Wilkinson, Jeremy M., Zeggini, Eleftheria

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Pathways to understanding the genomic aetiology of osteoarthritis von Cibrián Uhalte, Elena, Wilkinson, Jeremy Mark, Southam, Lorraine, Zeggini, Eleftheria

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A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis von Katsoula, Georgia, Steinberg, Julia, Tuerlings, Margo, Coutinho de Almeida, Rodrigo, Southam, Lorraine, Swift, Diane, Meulenbelt, Ingrid, Wilkinson, J Mark, Zeggini, Eleftheria

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Timing, rates and spectra of human germline mutation von Rahbari, Raheleh, Wuster, Arthur, Lindsay, Sarah J, Hardwick, Robert J, Alexandrov, Ludmil B, Al Turki, Saeed, Dominiczak, Anna, Morris, Andrew, Porteous, David, Smith, Blair, Stratton, Michael R, Hurles, Matthew E

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