Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders von Goldstein, David M, Kuglstatter, Andreas, Lou, Yan, Soth, Michael J

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Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy von Le, Kang, Soth, Michael J., Cross, Jason B., Liu, Gang, Ray, William J., Ma, Jiacheng, Goodwani, Sunil G., Acton, Paul J., Buggia-Prevot, Virginie, Akkermans, Onno, Barker, John, Conner, Michael L., Jiang, Yongying, Liu, Zhen, McEwan, Paul, Warner-Schmidt, Jennifer, Xu, Alan, Zebisch, Matthias, Heijnen, Cobi J., Abrahams, Brett, Jones, Philip

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Discovery of IPN60090, a Clinical Stage Selective Glutaminase‑1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties von Soth, Michael J, Le, Kang, Di Francesco, Maria Emilia, Hamilton, Matthew M, Liu, Gang, Burke, Jason P, Carroll, Chris L, Kovacs, Jeffrey J, Bardenhagen, Jennifer P, Bristow, Christopher A, Cardozo, Mario, Czako, Barbara, de Stanchina, Elisa, Feng, Ningping, Garvey, Jill R, Gay, Jason P, Do, Mary K. Geck, Greer, Jennifer, Han, Michelle, Harris, Angela, Herrera, Zachary, Huang, Sha, Giuliani, Virginia, Jiang, Yongying, Johnson, Sarah B, Johnson, Troy A, Kang, Zhijun, Leonard, Paul G, Liu, Zhen, McAfoos, Timothy, Miller, Meredith, Morlacchi, Pietro, Mullinax, Robert A, Palmer, Wylie S, Pang, Jihai, Rogers, Norma, Rudin, Charles M, Shepard, Hannah E, Spencer, Nakia D, Theroff, Jay, Wu, Qi, Xu, Alan, Yau, Ju Anne, Draetta, Giulio, Toniatti, Carlo, Heffernan, Timothy P, Jones, Philip

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Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1 von Fiskus, Warren, Mill, Christopher P., Birdwell, Christine, Davis, John A., Das, Kaberi, Boettcher, Steffen, Kadia, Tapan M., DiNardo, Courtney D., Takahashi, Koichi, Loghavi, Sanam, Soth, Michael J., Heffernan, Tim, McGeehan, Gerard M., Ruan, Xinjia, Su, Xiaoping, Vakoc, Christopher R., Daver, Naval, Bhalla, Kapil N.

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Inhibition of dual leucine zipper kinase prevents chemotherapy-induced peripheral neuropathy and cognitive impairments von Ma, Jiacheng, Goodwani, Sunil, Acton, Paul J., Buggia-Prevot, Virginie, Kesler, Shelli R., Jamal, Imran, Mahant, Iteeben D., Liu, Zhen, Mseeh, Faika, Roth, Bruce L., Chakraborty, Chaitali, Peng, Bo, Wu, Qi, Jiang, Yongying, Le, Kang, Soth, Michael J., Jones, Philip, Kavelaars, Annemieke, Ray, William J., Heijnen, Cobi J.

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Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis von Lou, Yan, Han, Xiaochun, Kuglstatter, Andreas, Kondru, Rama K., Sweeney, Zachary K., Soth, Michael, McIntosh, Joel, Litman, Renee, Suh, Judy, Kocer, Buelent, Davis, Dana, Park, Jaehyeon, Frauchiger, Sandra, Dewdney, Nolan, Zecic, Hasim, Taygerly, Joshua P., Sarma, Keshab, Hong, Junbae, Hill, Ronald J., Gabriel, Tobias, Goldstein, David M., Owens, Timothy D.

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Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions von Goodwani, Sunil, Fernandez, Celia, Acton, Paul J., Buggia-Prevot, Virginie, McReynolds, Morgan L., Ma, Jiacheng, Hu, Cheng Hui, Hamby, Mary E., Jiang, Yongying, Le, Kang, Soth, Michael J., Jones, Philip, Ray, William J.

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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme von Hamilton, Matthew M, Mseeh, Faika, McAfoos, Timothy J, Leonard, Paul G, Reyna, Naphtali J, Harris, Angela L, Xu, Alan, Han, Michelle, Soth, Michael J, Czako, Barbara, Theroff, Jay P, Mandal, Pijus K, Burke, Jason P, Virgin-Downey, Brett, Petrocchi, Alessia, Pfaffinger, Dana, Rogers, Norma E, Parker, Connor A, Yu, Simon S, Jiang, Yongying, Krapp, Stephan, Lammens, Alfred, Trevitt, Graham, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Cross, Jason B, Jones, Philip, Marszalek, Joseph R, Lewis, Richard T

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CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer von Yuan, Xueying, Hao, Xiaoxin, Chan, Hilda L, Zhao, Na, Pedroza, Diego A, Liu, Fengshuo, Le, Kang, Smith, Alex J, Calderon, Sebastian J, Lieu, Nadia, Soth, Michael J, Jones, Philip, Zhang, Xiang H-F, Rosen, Jeffrey M

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Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors von Jaime-Figueroa, Saul, De Vicente, Javier, Hermann, Johannes, Jahangir, Alam, Jin, Sue, Kuglstatter, Andreas, Lynch, Stephen M., Menke, John, Niu, Linghao, Patel, Vaishali, Shao, Ada, Soth, Michael, Vu, Minh Diem, Yee, Calvin

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Designed molecules that fold to mimic protein secondary structures von Stigers, Kimberly D, Soth, Michael J, Nowick, James S

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Synthesis of the C(1)−C(18) Segment of Lophotoxin and Pukalide. Control of 2-Alkenylfuran (E/Z)-Configuration von Wipf, Peter, Soth, Michael J

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Abstract B020: Reprogramming epithelial-mesenchymal transition and the immune microenvironment in triple-negative breast cancer with epigenetic drugs von Yuan, Xueying, Soth, Michael, Jones, Philip, Rosen, Jeffrey

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Unnatural oligomers and unnatural oligomer libraries von Soth, Michael J, Nowick, James S

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A Peptide/Oligourea/Azapeptide Hybrid That Adopts a Hairpin Turn von Soth, Michael J, Nowick, James S

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We Are All Relational, but Are Some More Relational Than Others?: Completing the Paradigm Shift Toward Relationality von Soth, Michael

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Abstract 1102: Integrated approach towards defining mechanism based combinations to guide clinical development of glutaminase inhibitors von Kovacs, Jeffrey J., Spencer, Nakia D., Bristow, Christopher A., Carugo, Alessandro, Giluiani, Virginia, Miller, Meredith A., Harris, Angela, Feng, Ningping, Soth, Michael L., Le, Kang, de Stanchina, Elisa, Rudin, Charles M., Draetta, Giulio, Yap, Timothy A., Jones, Philip, Heffernan, Timothy

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Abstract 2338: The GLS1 inhibitor IPN60090 enhances antitumor immune response through metabolic reprogramming of T cells and impacts on the tumor microenvironment von Suzuki, Erika, Molina, Jennifer, Spencer, Nakia D., Bristow, Christopher A., Harris, Angela L., Feng, Ningping, Mahendra, Mikhila, Gera, Sonal, Soth, Michael J., Le, Kang, Yap, Timothy A., Draetta, Giulio, Jones, Philip, Heffernan, Timothy P., Kovacs, Jeffrey J.

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Abstract 87: Asparagine synthetase (ASNS) expression predicts response to the GLS1 inhibitor IPN60090 in ovarian cancer through selective modulation of redox homeostasis von Spencer, Nakia D., Bristow, Christopher A., Giulani, Virginia, Miller, Meredith A., Carugo, Alessandro, Harris, Angela L., Minelli, Rosalba, Feng, Ningpeng, Chang, Qing, Soth, Michael J., Le, Kang, Weinstein, John N., Lorenzi, Philip L., Liu, Jinsong, Wang, Wei-Lien, Yap, Timothy A., Draetta, Giulio, Jones, Philip, Heffernan, Timothy P., Kovacs, Jeffrey J.

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First-in-human biomarker-driven phase I trial of the potent and selective glutaminase-1 (GLS1) inhibitor IACS-6274 (IPN60090) in patients (pts) with molecularly selected advanced s... von Yap, Timothy A., Dumbrava, Ecaterina Elena, Rodon Ahnert, Jordi, Hong, David S., Pant, Shubham, Karp, Daniel D., Piha-Paul, Sarina Anne Anne, Subbiah, Vivek, Tsimberidou, Apostolia Maria, Fu, Siqing, Janku, Filip, Montez, Sandra, Ahmad-Taha, Majd T, Guerrero, Darlene, Nazarenko, Natalya N., Moore, Yan, Soth, Michael, Kovacs, Jeff, Heffernan, Timothy P., Jones, Philip

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