Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis von Anderson, Daniel J., Le Moigne, Ronan, Djakovic, Stevan, Kumar, Brajesh, Rice, Julie, Wong, Steve, Wang, Jinhai, Yao, Bing, Valle, Eduardo, Kiss von Soly, Szerenke, Madriaga, Antonett, Soriano, Ferdie, Menon, Mary-Kamala, Wu, Zhi Yong, Kampmann, Martin, Chen, Yuwen, Weissman, Jonathan S., Aftab, Blake T., Yakes, F. Michael, Shawver, Laura, Zhou, Han-Jie, Wustrow, David, Rolfe, Mark

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Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083) von Zhou, Han-Jie, Wang, Jinhai, Yao, Bing, Wong, Steve, Djakovic, Stevan, Kumar, Brajesh, Rice, Julie, Valle, Eduardo, Soriano, Ferdie, Menon, Mary-Kamala, Madriaga, Antonett, Kiss von Soly, Szerenke, Kumar, Abhinav, Parlati, Francesco, Yakes, F. Michael, Shawver, Laura, Le Moigne, Ronan, Anderson, Daniel J, Rolfe, Mark, Wustrow, David

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Red Blood Cells Are the Major Source of Alpha-Synuclein in Blood von Barbour, Robin, Kling, Kristin, Anderson, John P., Banducci, Kelly, Cole, Tracy, Diep, Linnea, Fox, Michael, Goldstein, Jason M., Soriano, Ferdie, Seubert, Peter, Chilcote, Tamie J.

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793 Combined administration of the dual A2aR/A2bR antagonist etrumadenant with a reduced chemotherapy regimen leads to enhanced tumor efficacy and survival von Marubayashi, Sachie, Piovesan, Dana, Soriano, Ferdie, Barajas, Gonzalo, Flores, Ruben, Kline, Janine, Walters, Matthew J, DiRenzo, Daniel

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mRNA knockdown by single strand RNA is improved by chemical modifications von Haringsma, Henry J, Li, Jenny J, Soriano, Ferdie, Kenski, Denise M, Flanagan, W Michael, Willingham, Aarron T

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siRNA-optimized Modifications for Enhanced In Vivo Activity von Kenski, Denise M, Butora, Gabor, Willingham, Aarron T, Cooper, Abby J, Fu, Wenlang, Qi, Ning, Soriano, Ferdie, Davies, Ian W, Flanagan, W Michael

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258 AB308 is an anti-TIGIT antibody that enhances immune activation and anti-tumor immunity alone and in combination with other I-O therapeutic agents von Piovesan, Dana, Lopez, Alejandra, Schweickert, Patrick, Soriano, Ferdie, Cho, Soonweng, Chen, Ada, Singh, Hema, Zhao, Xiaoning, Young, Stephen, Walker, Nigel, Walters, Matthew, Gauthier, Kelsey Sivick

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Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9[S] von Ason, Brandon, Tep, Samnang, Davis, Jr. Harry R., Xu, Yiming, Tetzloff, Glen, Galinski, Beverly, Soriano, Ferdie, Dubinina, Natalya, Zhu, Lei, Stefanni, Alice, Wong, Kenny K., Tadin-Strapps, Marija, Bartz, Steven R., Hubbard, Brian, Ranalletta, Mollie, Sachs, Alan B., Flanagan, W. Michael, Strack, Alison, Kuklin, Nelly A.

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Anti-TIGIT antibodies promote immune activation relevant to targeting stem-like and tumor-specific T cells in combination with anti-PD-1 von Sivick Gauthier, Kelsey E, Piovesan, Dana, de Groot, Amber E, Reiner, Gabrielle L, Schweickert, Patrick G, Soriano, Ferdie, Chen, Ada, Singh, Hema, Zhao, Xiaoning, Seitz, Lisa, Reddy, Anita, Young, Stephen W, Walker, Nigel, Walters, Matthew J

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The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma von Le Moigne, Ronan, Aftab, Blake T, Djakovic, Stevan, Dhimolea, Eugen, Valle, Eduardo, Murnane, Megan, King, Emily M, Soriano, Ferdie, Menon, Mary-Kamala, Wu, Zhi Yong, Wong, Stephen T, Lee, Grace J, Yao, Bing, Wiita, Arun P, Lam, Christine, Rice, Julie, Wang, Jinhai, Chesi, Marta, Bergsagel, P Leif, Kraus, Marianne, Driessen, Christoph, Kiss von Soly, Szerenke, Yakes, F Michael, Wustrow, David, Shawver, Laura, Zhou, Han-Jie, Martin, 3rd, Thomas G, Wolf, Jeffrey L, Mitsiades, Constantine S, Anderson, Daniel J, Rolfe, Mark

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Abstract 5556: Combining adenosine receptor inhibition with AB928 and chemotherapy results in greater immune activation and tumor control von Walters, Matt J., Piovesan, Dana, Tan, Joanne, DiRenzo, Daniel, Yin, Fangfang, Miles, Dillon, Leleti, Manmohan R., Park, Tim, Soriano, Ferdie, Sharif, Eshan, Schindler, Ulrike, Powers, Jay P.

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Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System von Inglis, Kelly J., Chereau, David, Brigham, Elizabeth F., Chiou, San-San, Schöbel, Susanne, Frigon, Normand L., Yu, Mei, Caccavello, Russell J., Nelson, Seth, Motter, Ruth, Wright, Sarah, Chian, David, Santiago, Pamela, Soriano, Ferdie, Ramos, Carla, Powell, Kyle, Goldstein, Jason M., Babcock, Michael, Yednock, Ted, Bard, Frederique, Basi, Guriqbal S., Sham, Hing, Chilcote, Tamie J., McConlogue, Lisa, Griswold-Prenner, Irene, Anderson, John P.

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Abstract 3769: Pharmacokinetic-pharmacodynamic relationship for AB928, a dual antagonist of the A2aR and A2bR adenosine receptors von Seitz, Lisa, Ashok, Devika, Leleti, Manmohan R., Powers, Jay P., Rosen, Brandon, Miles, Dillon, Jin, Lixia, Park, Adam, Park, Tim, Young, Steve, Soriano, Ferdie, Rieger, Aimee, Schindler, Ulrike, Karakunnel, Joyson, Walters, Matt J.

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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease von Bard, Frédérique, Cannon, Catherine, Barbour, Robin, Burke, Rae-Lyn, Games, Dora, Grajeda, Henry, Guido, Teresa, Hu, Kang, Huang, Jiping, Johnson-Wood, Kelly, Khan, Karen, Kholodenko, Dora, Lee, Mike, Lieberburg, Ivan, Motter, Ruth, Nguyen, Minh, Soriano, Ferdie, Vasquez, Nicki, Weiss, Kim, Welch, Brent, Seubert, Peter, Schenk, Dale, Yednock, Ted

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Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse von Schenk, Dale, Barbour, Robin, Dunn, Whitney, Gordon, Grace, Grajeda, Henry, Guido, Teresa, Hu, Kang, Huang, Jiping, Johnson-Wood, Kelly, Khan, Karen, Kholodenko, Dora, Lee, Mike, Liao, Zhenmei, Lieberburg, Ivan, Motter, Ruth, Mutter, Linda, Soriano, Ferdie, Shopp, George, Vasquez, Nicki, Vandevert, Christopher, Walker, Shannan, Wogulis, Mark, Yednock, Ted, Games, Dora, Seubert, Peter

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Abstract 4541: Utilization of K48 poly-ubiquitin modulation as a biomarker of target engagement for a protein homeostasis inhibitor in the clinic: Preclinical validation with CB-50... von MENON, Mary-Kamala, SORIANO, Ferdie, WONG, Steve, VALLE, Eduardo, Djakovic, Stevan, KUMAR, Brajesh, YAO, Bing, MADRIAGA, Antonett, WU, Tony, RICE, Julie, WANG, Jinhai, CESANO, Alessandra, SHAWVER, Laura, ZHOU, Han-Jie, WUSTROW, David, ANDERSON, Daniel, ROLFE, Mark, LE MOIGNE, Ronan

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CB‐5083: A p97 Inhibitor Disrupts Cellular Protein Homeostasis and Shows Potent Anti‐Tumor Effects von Kumar, Brajesh, Rice, Julie, Djakovic, Stevan, Madriaga, Antonett, Wong, Steve, Valle, Eduardo, Menon, Mk, Wang, Jinhai, Soly, Szerenke, Soriano, Ferdie, Yao, Bing, Le Moigne, Ronan, Zhou, Han‐jie, Wustrow, David, Rolfe, Mark, Anderson, Daniel

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Abstract A162: AB928, a dual antagonist of the A2aR and A2bR adenosine receptors, relieves adenosine-mediated immune suppression von DiRenzo, Daniel, Piovesan, Dana, Tan, Joanne, Miles, Dillon H., Leleti, Manmohan R., Park, Timothy, Soriano, Ferdie, Handlos, Bryan, Jeffrey, Jenna L., Sharif, Ehesan U., Rosen, Brandon R., Schindler, Ulrike, Powers, Jay P., Walters, Matthew J.

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Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse von Irizarry, Michael C., Soriano, Ferdie, McNamara, Megan, Page, Keith J., Schenk, Dale, Games, Dora, Hyman, Bradley T.

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Pre-Clinical Activity of the Novel, First-in-Class p97 Inhibitor, CB-5083, in Multiple Myeloma von Aftab, Blake T., Anderson, Daniel J, Le Moigne, Ronan, Djakovic, Stevan, Dhimolea, Eugen, Murnane, Megan, King, Emily, Rice, Julie, Wong, Steve, Kumar, Brajesh, Valle, Eduardo, Menon, Mary-Kamala, Kiss von Soly, Szerenke, Wang, Jinhai, Yao, Bing, Soriano, Ferdie, Kampmann, Martin, Alcost-Alvear, Diego, Chesi, Marta, Bergsagel, Leif, Yakes, F. Michael, Zhou, Han-Jie, Wustrow, David, Martin, Thomas G., Wolf, Jeffrey L., Mitsiades, Constantine S., Rolfe, Mark

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