DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitoch... von Bharti, Sanjay Kumar, Sommers, Joshua A., Zhou, Jun, Kaplan, Daniel L., Spelbrink, Johannes N., Mergny, Jean-Louis, Brosh, Robert M.

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WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells von Datta, Arindam, Biswas, Kajal, Sommers, Joshua A., Thompson, Haley, Awate, Sanket, Nicolae, Claudia M., Thakar, Tanay, Moldovan, George-Lucian, Shoemaker, Robert H., Sharan, Shyam K., Brosh, Robert M.

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A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN) von Sommers, Joshua A, Kulikowicz, Tomasz, Croteau, Deborah L, Dexheimer, Thomas, Dorjsuren, Dorjbal, Jadhav, Ajit, Maloney, David J, Simeonov, Anton, Bohr, Vilhelm A, Brosh, Jr, Robert M

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Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress von Aggarwal, Monika, Sommers, Joshua A, Shoemaker, Robert H, Brosh, Robert M. Jr

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CDK1 phosphorylates WRN at collapsed replication forks von Palermo, Valentina, Rinalducci, Sara, Sanchez, Massimo, Grillini, Francesca, Sommers, Joshua A., Brosh, Robert M., Zolla, Lello, Franchitto, Annapaola, Pichierri, Pietro

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Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks von Parvathaneni, Swetha, Stortchevoi, Alexei, Sommers, Joshua A, Brosh, Jr, Robert M, Sharma, Sudha

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Impact of age-associated cyclopurine lesions on DNA repair helicases von Khan, Irfan, Suhasini, Avvaru N, Banerjee, Taraswi, Sommers, Joshua A, Kaplan, Daniel L, Kuper, Jochen, Kisker, Caroline, Brosh, Jr, Robert M

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Biochemical Characterization of Warsaw Breakage Syndrome Helicase von Wu, Yuliang, Sommers, Joshua A., Khan, Irfan, de Winter, Johan P., Brosh, Robert M.

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Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway von AGGARWAL, Monika, BANERJEE, Taraswi, SOMMERS, Joshua A, LANNASCOLI, Chiara, PICHIERRI, Pietro, SHOEMAKER, Robert H, BROSH, Robert M

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Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome von Bharti, Sanjay Kumar, Khan, Irfan, Banerjee, Taraswi, Sommers, Joshua A, Wu, Yuliang, Brosh, Robert M., Jr

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Biochemical and cell biological assays to identify and characterize DNA helicase inhibitors von Banerjee, Taraswi, Aggarwal, Monika, Sommers, Joshua A., Brosh, Robert M.

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A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair von Bharti, Sanjay Kumar, Sommers, Joshua A, Awate, Sanket, Bellani, Marina A, Khan, Irfan, Bradley, Lynda, King, Graeme A, Seol, Yeonee, Vidhyasagar, Venkatasubramanian, Wu, Yuliang, Abe, Takuye, Kobayashi, Koji, Shin-ya, Kazuo, Kitao, Hiroyuki, Wold, Marc S, Branzei, Dana, Neuman, Keir C, Brosh, Robert M

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Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome von Suhasini, Avvaru N, Rawtani, Nina A, Wu, Yuliang, Sommers, Joshua A, Sharma, Sudha, Mosedale, Georgina, North, Phillip S, Cantor, Sharon B, Hickson, Ian D, Brosh Jr, Robert M

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Novel Function of the Fanconi Anemia Group J or RECQ1 Helicase to Disrupt Protein-DNA Complexes in a Replication Protein A-stimulated Manner von Sommers, Joshua A., Banerjee, Taraswi, Hinds, Twila, Wan, Bingbing, Wold, Marc S., Lei, Ming, Brosh, Robert M.

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Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes von Wu, Yuliang, Sommers, Joshua A., Suhasini, Avvaru N., Leonard, Thomas, Deakyne, Julianna S., Mazin, Alexander V., Shin-ya, Kazuo, Kitao, Hiroyuki, Brosh, Robert M.

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FANCJ Uses Its Motor ATPase to Destabilize Protein-DNA Complexes, Unwind Triplexes, and Inhibit RAD51 Strand Exchange von Sommers, Joshua A., Rawtani, Nina, Gupta, Rigu, Bugreev, Dmitry V., Mazin, Alexander V., Cantor, Sharon B., Brosh, Robert M.

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Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact To Facilitate the DNA Damage Response von Suhasini, Avvaru N., Sommers, Joshua A., Muniandy, Parameswary A., Coulombe, Yan, Cantor, Sharon B., Masson, Jean-Yves, Seidman, Michael M., Brosh, Robert M.

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The Q Motif of Fanconi Anemia Group J Protein (FANCJ) DNA Helicase Regulates Its Dimerization, DNA Binding, and DNA Repair Function von Wu, Yuliang, Sommers, Joshua A., Loiland, Jason A., Kitao, Hiroyuki, Kuper, Jochen, Kisker, Caroline, Brosh, Robert M.

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Biochemical Analysis of the DNA Unwinding and Strand Annealing Activities Catalyzed by Human RECQ1[boxs] von Sharma, Sudha, Sommers, Joshua A., Choudhary, Saba, Faulkner, Jinnifer Korin, Cui, Sheng, Andreoli, Lucia, Muzzolini, Laura, Vindigni, Alessandro, Brosh, Robert M.

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Analysis of the DNA Substrate Specificity of the Human BACH1 Helicase Associated with Breast Cancer von Gupta, Rigu, Sharma, Sudha, Sommers, Joshua A, Jin, Zhe, Cantor, Sharon B, Brosh, Jr, Robert M

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