Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera von Wernig, Gerlinde, Kharas, Michael G., Okabe, Rachel, Moore, Sandra A., Leeman, Dena S., Cullen, Dana E., Gozo, Maricel, McDowell, Elizabeth P., Levine, Ross L., Doukas, John, Mak, Chi Ching, Noronha, Glenn, Martin, Michael, Ko, Yon D., Lee, Benjamin H., Soll, Richard M., Tefferi, Ayalew, Hood, John D., Gilliland, D. Gary

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Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity von Coburn, Craig A., Meinke, Peter T., Chang, Wei, Fandozzi, Christine M., Graham, Donald J., Hu, Bin, Huang, Qian, Kargman, Stacia, Kozlowski, Joseph, Liu, Rong, McCauley, John A., Nomeir, Amin A., Soll, Richard M., Vacca, Joseph P., Wang, Dahai, Wu, Hao, Zhong, Bin, Olsen, David B., Ludmerer, Steven W.

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Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury von Doukas, John, Wrasidlo, Wolfgang, Noronha, Glenn, Dneprovskaia, Elena, Fine, Richard, Weis, Sara, Hood, John, DeMaria, Anthony, Soll, Richard, Cheresh, David

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Selective Inhibition of JAK2-Driven Erythroid Differentiation of Polycythemia Vera Progenitors von Geron, Ifat, Abrahamsson, Annelie E., Barroga, Charlene F., Kavalerchik, Edward, Gotlib, Jason, Hood, John D., Durocher, Jeffrey, Mak, Chi Ching, Noronha, Glenn, Soll, Richard M., Tefferi, Ayalew, Kaushansky, Ken, Jamieson, Catriona H.M.

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Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction von Weis, Sara, Shintani, Satoshi, Weber, Alberto, Kirchmair, Rudolf, Wood, Malcolm, Cravens, Adrianna, McSharry, Heather, Iwakura, Atsushi, Yoon, Young-Sup, Himes, Nathan, Burstein, Deborah, Doukas, John, Soll, Richard, Losordo, Douglas, Cheresh, David

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Design, Synthesis, Structure–Function Relationship, Bioconversion, and Pharmacokinetic Evaluation of Ertapenem Prodrugs von Singh, Sheo B, Rindgen, Diane, Bradley, Prudence, Suzuki, Takao, Wang, Nengxue, Wu, Hao, Zhang, Basheng, Wang, Li, Ji, Chongmin, Yu, Hongshi, Soll, Richard M, Olsen, David B, Meinke, Peter T, Nicoll-Griffith, Deborah A

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Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits von Scheppke, Lea, Aguilar, Edith, Gariano, Ray F, Jacobson, Ruth, Hood, John, Doukas, John, Cao, Jon, Noronha, Glenn, Yee, Shiyin, Weis, Sara, Martin, Michael B, Soll, Richard, Cheresh, David A, Friedlander, Martin

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Development of a New Structural Class of Broadly Acting HCV Non‐Nucleoside Inhibitors Leading to the Discovery of MK‐8876 von McComas, Casey C., Palani, Anandan, Chang, Wei, Holloway, M. Katharine, Lesburg, Charles A., Li, Peng, Liverton, Nigel, Meinke, Peter T., Olsen, David B., Peng, Xuanjia, Soll, Richard M., Ummat, Ajay, Wu, Jie, Wu, Jin, Zorn, Nicolas, Ludmerer, Steven W.

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Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors von Tong, Ling, Yu, Wensheng, Coburn, Craig A., Meinke, Peter T., Nair, Anilkumar G., Dwyer, Michael P., Chen, Lei, Selyutin, Oleg, Rosenblum, Stuart B., Jiang, Yueheng, Fells, James, Hu, Bin, Zhong, Bin, Soll, Richard M., Liu, Rong, Agrawal, Sony, Xia, Ellen, Zhai, Ying, Kong, Rong, Ingravallo, Paul, Nomeir, Amin, Asante-Appiah, Ernest, Kozlowski, Joseph A.

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Discovery of a Pharmacologically Active Antagonist of the Two-Pore-Domain Potassium Channel K2P9.1 (TASK-3) von Coburn, Craig A., Luo, Yunfu, Cui, Mingxiang, Wang, Jiabing, Soll, Richard, Dong, Jingchao, Hu, Bin, Lyon, Michael A., Santarelli, Vincent P., Kraus, Richard L., Gregan, Yun, Wang, Yi, Fox, Steven V., Binns, Jacquelyn, Doran, Scott M., Reiss, Duane R., Tannenbaum, Pamela L., Gotter, Anthony L., Meinke, Peter T., Renger, John J.

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Front Cover: Development of a New Structural Class of Broadly Acting HCV Non‐Nucleoside Inhibitors Leading to the Discovery of MK‐8876 (ChemMedChem 17/2017) von McComas, Casey C., Palani, Anandan, Chang, Wei, Holloway, M. Katharine, Lesburg, Charles A., Li, Peng, Liverton, Nigel, Meinke, Peter T., Olsen, David B., Peng, Xuanjia, Soll, Richard M., Ummat, Ajay, Wu, Jie, Wu, Jin, Zorn, Nicolas, Ludmerer, Steven W.

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Discovery of 3,3‘-(2,4-Diaminopteridine-6,7-diyl)diphenol as an Isozyme-Selective Inhibitor of PI3K for the Treatment of Ischemia Reperfusion Injury Associated with Myocardial Infa... von Palanki, Moorthy S. S, Dneprovskaia, Elena, Doukas, John, Fine, Richard M, Hood, John, Kang, Xinshan, Lohse, Dan, Martin, Michael, Noronha, Glenn, Soll, Richard M, Wrasidlo, Wolfgang, Yee, Shiyin, Zhu, Hong

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Development of Prodrug 4-Chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl Benzoate (TG100801): A Topically Administered Therapeutic Ca... von Palanki, Moorthy S. S, Akiyama, Hideo, Campochiaro, Peter, Cao, Jianguo, Chow, Chun P, Dellamary, Luis, Doukas, John, Fine, Richard, Gritzen, Colleen, Hood, John D, Hu, Steven, Kachi, Shu, Kang, Xinshan, Klebansky, Boris, Kousba, Ahmed, Lohse, Dan, Mak, Chi Ching, Martin, Michael, McPherson, Andrew, Pathak, Ved P, Renick, Joel, Soll, Richard, Umeda, Naoyasu, Yee, Shiyin, Yokoi, Katsutoshi, Zeng, Binqi, Zhu, Hong, Noronha, Glenn

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Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s von Subasinghe, Nalin L., Khalil, Ehab, Travins, Jeremy M., Ali, Farah, Ballentine, Shelley K., Hufnagel, Heather R., Pan, Wenxi, Leonard, Kristi, Bone, Roger F., Soll, Richard M., Crysler, Carl S., Ninan, Nisha, Kirkpatrick, Jennifer, Kolpak, Michael X., Diloreto, Karen A., Eisennagel, Stephen H., Huebert, Norman D., Molloy, Christopher J., Tomczuk, Bruce E., Gaul, Michael D.

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Discovery and preliminary structure–activity relationship studies of novel benzotriazine based compounds as Src inhibitors von Noronha, Glenn, Barrett, Kathy, Cao, Jianguo, Dneprovskaia, Elena, Fine, Richard, Gong, Xianchang, Gritzen, Colleen, Hood, John, Kang, Xinshan, Klebansky, Boris, Li, G., Liao, W., Lohse, Dan, Mak, Chi Ching, McPherson, Andrew, Palanki, Moorthy S.S., Pathak, Ved P., Renick, Joel, Soll, Richard, Splittgerber, Ute, Wrasidlo, Wolfgang, Zeng, Binqi, Zhao, Ningning, Zhou, Y.

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Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s von Travins, Jeremy M., Ali, Farah, Huang, Hui, Ballentine, Shelley K., Khalil, Ehab, Hufnagel, Heather R., Pan, Wenxi, Gushue, Joan, Leonard, Kristi, Bone, Roger F., Soll, Richard M., DesJarlais, Renee L., Crysler, Carl S., Ninan, Nisha, Kirkpatrick, Jennifer, Cummings, Maxwell D., Huebert, Norman, Molloy, Christopher J., Gaul, Michael, Tomczuk, Bruce E., Subasinghe, Nalin L.

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Synthesis and insecticidal activity of fluorinated 2-(2,6-dichloro-4-trifluoromethylphenyl)-2,4,5,6-tetrahydrocyclopentapyrazoles von Meegalla, Sanath K., Doller, Dario, Liu, Ruiping, Sha, DeYou, Lee, YuKai, Soll, Richard M., Wisnewski, Nancy, Silver, Gary M., Dhanoa, Dale

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Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4 von Chana, Chetan K., Maisonneuve, Pierre, Posternak, Ganna, Grinberg, Nicolas G.A., Poirson, Juline, Ona, Samara M., Ceccarelli, Derek F., Mader, Pavel, St-Cyr, Daniel J., Pau, Victor, Kurinov, Igor, Tang, Xiaojing, Deng, Dongjing, Cui, Weiren, Su, Wenji, Kuai, Letian, Soll, Richard, Tyers, Mike, Röst, Hannes L., Batey, Robert A., Taipale, Mikko, Gingras, Anne-Claude, Sicheri, Frank

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Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis von TIANBAO LU, MARKOTAN, Thomas, BONE, Roger, COPPO, Frank, TOMCZUK, Bruce, CRYSLER, Carl, EISENNAGEL, Stephen, SPURLINO, John, GREMMINGER, Lisa, SOLL, Richard M, GIARDINO, Edward C

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Deep learning enables rapid identification of potent DDR1 kinase inhibitors von Zhavoronkov, Alex, Ivanenkov, Yan A., Aliper, Alex, Veselov, Mark S., Aladinskiy, Vladimir A., Aladinskaya, Anastasiya V., Terentiev, Victor A., Polykovskiy, Daniil A., Kuznetsov, Maksim D., Asadulaev, Arip, Volkov, Yury, Zholus, Artem, Shayakhmetov, Rim R., Zhebrak, Alexander, Minaeva, Lidiya I., Zagribelnyy, Bogdan A., Lee, Lennart H., Soll, Richard, Madge, David, Xing, Li, Guo, Tao, Aspuru-Guzik, Alán

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