Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase von Sofia, Michael J, Chang, Wonsuk, Furman, Phillip A, Mosley, Ralph T, Ross, Bruce S

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Structural basis for RNA replication by the hepatitis C virus polymerase von Appleby, Todd C., Perry, Jason K., Murakami, Eisuke, Barauskas, Ona, Feng, Joy, Cho, Aesop, Fox, David, Wetmore, Diana R., McGrath, Mary E., Ray, Adrian S., Sofia, Michael J., Swaminathan, S., Edwards, Thomas E.

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Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1 von Park, Jang-June, Thi, Emily P., Carpio, Victor H., Bi, Yingzhi, Cole, Andrew G., Dorsey, Bruce D., Fan, Kristi, Harasym, Troy, Iott, Christina L., Kadhim, Salam, Kim, Jin Hyang, Lee, Amy C. H., Nguyen, Duyan, Paratala, Bhavna S., Qiu, Ruiqing, White, Andre, Lakshminarasimhan, Damodharan, Leo, Christopher, Suto, Robert K., Rijnbrand, Rene, Tang, Sunny, Sofia, Michael J., Moore, Chris B.

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Nucleotide Prodrugs for HCV Therapy von Sofia, Michael J

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PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication von LAM, Angela M, MURAKAMI, Eisuke, MORREY, John D, SMEE, Donald F, FRICK, David N, HECK, Julie A, PEIYUAN WANG, NAGARATHNAM, Dhanapalan, ROSS, Bruce S, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, ESPIRITU, Christine, MICOLOCHICK STEUER, Holly M, NIU, Congrong, KEILMAN, Meg, HAIYING BAO, ZENNOU, Veronique, BOURNE, Nigel, JULANDER, Justin G

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Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161 von Lam, Angela M, Dugyala, Ravi R, Sheraz, Muhammed, Liu, Fei, Thi, Emily P, Graves, Ingrid E, Cuconati, Andrea, Steuer, Holly Micolochick, Ardzinski, Andrzej, Overholt, Nathan, Mason, Jeremy D, Gotchev, Dimitar, Cole, Andrew G, Harasym, Troy O, Sofia, Michael J

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Enter Sofosbuvir: The Path to Curing HCV von Sofia, Michael J.

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Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus von Sofia, Michael J, Bao, Donghui, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Wang, Peiyuan, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine, Keilman, Meg, Lam, Angela M, Steuer, Holly M. Micolochick, Niu, Congrong, Otto, Michael J, Furman, Phillip A

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Pregenomic RNA Launch Hepatitis B Virus Replication System Facilitates the Mechanistic Study of Antiviral Agents and Drug-Resistant Variants on Covalently Closed Circular DNA Synth... von Zhao, Qiong, Chang, Jinhong, Rijnbrand, Rene, Lam, Angela M, Sofia, Michael J, Cuconati, Andrea, Guo, Ju-Tao

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Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938 von CONGRONG NIU, TOLSTYKH, Tatiana, ZHANG, Hai-Ren, WOOLLY, Joseph, WANG, Li-Quan, CHAO, Piyun B, RAY, Adrian S, OTTO, Michael J, SOFIA, Michael J, FURMAN, Phillip A, MURAKAMI, Eisuke, HAIYING BAO, PARK, Yeojin, BABUSIS, Darius, LAM, Angela M, BANSAL, Shalini, JINFA DU, CHANG, Wonsuk, GANAPATI REDDY, P

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Inhibition of HBV replication by N-hydroxyisoquinolinedione and N-hydroxypyridinedione ribonuclease H inhibitors von Edwards, Tiffany C., Mani, Nagraj, Dorsey, Bruce, Kakarla, Ramesh, Rijnbrand, Rene, Sofia, Michael J., Tavis, John E.

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HCV: The Journey from Discovery to a Cure: Volume I von Sofia, Michael J

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Circulating serum HBsAg level is a biomarker for HBV-specific T and B cell responses in chronic hepatitis B patients von Kim, Jin Hyang, Ghosh, Alip, Ayithan, Natarajan, Romani, Sara, Khanam, Arshi, Park, Jang-June, Rijnbrand, Rene, Tang, Lydia, Sofia, Michael J., Kottilil, Shyam, Moore, Chris B., Poonia, Bhawna

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Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection von Chang, Wonsuk, Bao, Donghui, Chun, Byoung-Kwon, Naduthambi, Devan, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine L, Keilman, Meg, Lam, Angela M, Niu, Congrong, Steuer, Holly Micolochick, Furman, Phillip A, Otto, Michael J, Sofia, Michael J

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Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical C... von Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Fan, Kristi Yi, Ardzinski, Andrzej, Stever, Kim, Dorsey, Bruce D., Mesaros, Eugen F., Thi, Emily P., Graves, Ingrid, Tang, Sunny, Harasym, Troy O., Lee, Amy C. H., Olland, Andrea, Suto, Robert K., Sofia, Michael J.

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Editorial overview: Anti-infectives von Furman, Phillip, Sofia, Michael J

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Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA von Liu, Fei, Lee, Amy C. H., Guo, Fang, Kondratowicz, Andrew S., Steuer, Holly M. Micolochick, Miller, Angela, Bailey, Lauren D., Wang, Xiaohe, Chen, Shuai, Kultgen, Steven G., Cuconati, Andrea, Cole, Andrew G., Gotchev, Dimitar, Dorsey, Bruce D., Rijnbrand, Rene, Lam, Angela M., Sofia, Michael J., Gao, Min

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Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 M pro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavir... von Wang, Xu, Gotchev, Dimitar, Fan, Kristi Yi, Vega, Marvin M, Mani, Nagraj, McGovern-Gooch, Kayleigh, Cuconati, Andrea, Tercero, Breanna, Wang, Xiaohe, Carpino, Philip, Maskos, Klaus, Centrella, Paolo A, Schmitt, Andreas, Preuss, Franziska, Prasad, Archna, Chen, Chia-Yi, Clark, Matthew A, Guilinger, John P, Johnstone, Shawn, von König, Konstanze, Keefe, Anthony D, Liu, Jenny, Turcotte, Stéphane, Zhang, Ying, Konz Makino, Debora L, Lam, Angela M, Cole, Andrew G, Sofia, Michael J

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Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506 von Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Quintero, Jorge G., Yi Fan, Kristi, Ardzinski, Andrzej, Stever, Kim, Dorsey, Bruce D., Phelps, Janet R., Lee, Amy C.H., Thi, Emily P., Chiu, Tim, Tang, Sunny, Horanyi, Peter S., Mayclin, Stephen J., Harasym, Troy O., Sofia, Michael J.

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Biological characterization of AB-343, a novel and potent SARS-CoV-2 Mpro inhibitor with pan-coronavirus activity von McGovern-Gooch, Kayleigh R., Mani, Nagraj, Gotchev, Dimitar, Ardzinski, Andrzej, Kowalski, Rose, Sheraz, Muhammad, Micolochick Steuer, Holly M., Tercero, Breanna, Wang, Xiaohe, Wasserman, Adam, Chen, Chia-yi, von König, Konstanze, Maskos, Klaus, Prasad, Archna, Blaesse, Michael, Bergmann, Andreas, Konz Makino, Debora L., Fan, Kristi Y., Kultgen, Steven G., Lindstrom, Aaron, Nguyen, Duyan, Vega, Marvin, Wang, Xu, Bracci, Nicole, Weiss, Susan R., Cole, Andrew G., Lam, Angela M., Cuconati, Andrea, Sofia, Michael J.

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