Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance von Rozengurt, Enrique, Soares, Heloisa P, Sinnet-Smith, James

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Adjuvant Therapy for Resected Biliary Tract Cancer: ASCO Clinical Practice Guideline von Shroff, Rachna T, Kennedy, Erin B, Bachini, Melinda, Bekaii-Saab, Tanios, Crane, Christopher, Edeline, Julien, El-Khoueiry, Anthony, Feng, Mary, Katz, Matthew H G, Primrose, John, Soares, Heloisa P, Valle, Juan, Maithel, Shishir K

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Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells von Soares, Heloisa P, Ni, Yang, Kisfalvi, Krisztina, Sinnett-Smith, James, Rozengurt, Enrique

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Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2 von Soares, Heloisa P, Ming, Ming, Mellon, Michelle, Young, Steven H, Han, Liang, Sinnet-Smith, James, Rozengurt, Enrique

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Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells von Ming, Ming, Sinnett-Smith, James, Wang, Jia, Soares, Heloisa P, Young, Steven H, Eibl, Guido, Rozengurt, Enrique

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An Update on the Management of Mixed Neuroendocrine-Non-neuroendocrine Neoplasms (MiNEN) von Jacob, Aasems, Raj, Rishi, Allison, Derek B., Soares, Heloisa P., Chauhan, Aman

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A Phase II Study of Ibrutinib in Advanced Neuroendocrine Neoplasms von Al-Toubah, Taymeyah, Schell, Michael J., Cives, Mauro, Zhou, Jun-Min, Soares, Heloisa P., Strosberg, Jonathan R.

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A single center case series of immune checkpoint inhibitor-induced type 1 diabetes mellitus, patterns of disease onset and long-term clinical outcome von Marsiglio, John, McPherson, Jordan P, Kovacsovics-Bankowski, Magdalena, Jeter, Joanne, Vaklavas, Christos, Swami, Umang, Grossmann, Douglas, Erickson-Wayman, Alyssa, Soares, Heloisa P, Kerrigan, Katie, Gibson, Berit, Doherty, Jennifer Anne, Hyngstrom, John, Hardikar, Sheetal, Hu-Lieskovan, Siwen

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Treatment Tolerance and Efficacy in Geriatric Oncology: A Systematic Review of Phase III Randomized Trials Conducted by Five National Cancer Institute–Sponsored Cooperative Groups... von KUMAR, Ambuj, SCARES, Heloisa P, BALDUCCI, Lodovico, DJULBEGOVIC, Benjamin

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Real-world pan-cancer landscape of frameshift mutations and their role in predicting responses to immune checkpoint inhibitors in cancers with low tumor mutational burden von Florou, Vaia, Floudas, Charalampos S, Maoz, Asaf, Naqash, Abdul Rafeh, Norton, Carter, Tan, Aik Choon, Sokol, Ethan S, Frampton, Garrett, Soares, Heloisa P, Puri, Sonam, Swami, Umang, Wilky, Breelyn, Hosein, Peter, Trent, Jonathan, Lopes, Gilberto de Lima, Park, Wungki, Garrido-Laguna, Ignacio

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Will clinical heterogeneity of neuroendocrine tumors impact their management in the future? Lessons from recent trials von Cives, Mauro, Soares, Heloisa P, Strosberg, Jonathan

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Quality of Life and Symptom Management in Advanced Biliary Tract Cancers von Hunter, Lindsay A, Soares, Heloisa P

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Published methodological quality of randomized controlled trials does not reflect the actual quality assessed in protocols von Mhaskar, Rahul, Djulbegovic, Benjamin, Magazin, Anja, Soares, Heloisa P, Kumar, Ambuj

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Comparative Genomic Analysis of Pancreatic Acinar Cell Carcinoma (PACC) and Pancreatic Ductal Adenocarcinoma (PDAC) Unveils New Actionable Genomic Aberrations in PACC von Florou, Vaia, Elliott, Andrew, Bailey, Matthew H, Stone, David, Affolter, Kajsa, Soares, Heloisa P, Nevala-Plagemann, Chris, Scaife, Courtney, Walker, Phillip, Korn, W Michael, Lou, Emil, Shroff, Rachna T, Hosein, Peter J, Garrido-Laguna, Ignacio

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Expert Consensus Practice Recommendations of the North American Neuroendocrine Tumor Society for the management of high grade gastroenteropancreatic and gynecologic neuroendocrine... von Eads, Jennifer R, Halfdanarson, Thorvardur R, Asmis, Tim, Bellizzi, Andrew M, Bergsland, Emily K, Dasari, Arvind, El-Haddad, Ghassan, Frumovitz, Michael, Meyer, Joshua, Mittra, Erik, Myrehaug, Sten, Nakakura, Eric, Raj, Nitya, Soares, Heloisa P, Untch, Brian, Vijayvergia, Namrata, Chan, Jennifer A

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Systemic Therapy for Tumor Control in Metastatic Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors: ASCO Guideline von Del Rivero, Jaydira, Perez, Kimberly, Kennedy, Erin B, Mittra, Erik S, Vijayvergia, Namrata, Arshad, Junaid, Basu, Sandip, Chauhan, Aman, Dasari, Arvind N, Bellizzi, Andrew M, Gangi, Alexandra, Grady, Erin, Howe, James R, Ivanidze, Jana, Lewis, Mark, Mailman, Josh, Raj, Nitya, Soares, Heloisa P, Soulen, Michael C, White, Sarah B, Chan, Jennifer A, Kunz, Pamela L, Singh, Simron, Halfdanarson, Thorvardur R, Strosberg, Jonathan R, Bergsland, Emily K

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Use of Molecular Assays and Circulating Tumor DNA in Early‐Stage Colorectal Cancer: A Roundtable Discussion of the Gastrointestinal Cancer Therapy Expert Group von Loaiza‐Bonilla, Arturo, Benson, Al B., Grothey, Axel, Karimi, Misagh, Klempner, Samuel J., Lin, Daniel, Mahtani, Reshma, Soares, Heloisa P.

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Stopping Randomized Trials Early for Benefit and Estimation of Treatment Effects: Systematic Review and Meta-regression Analysis von Bassler, Dirk, Briel, Matthias, Montori, Victor M, Lane, Melanie, Glasziou, Paul, Zhou, Qi, Heels-Ansdell, Diane, Walter, Stephen D, Guyatt, Gordon H, STOPIT-2 Study Group, and the

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Consensus report of the 2021 National Cancer Institute neuroendocrine tumor clinical trials planning meeting von Singh, Simron, Hope, Thomas A, Bergsland, Emily B, Bodei, Lisa, Bushnell, David L, Chan, Jennifer A, Chasen, Beth R, Chauhan, Aman, Das, Satya, Dasari, Arvind, Del Rivero, Jaydira, El-Haddad, Ghassan, Goodman, Karyn A, Halperin, Daniel M, Lewis, Mark A, Lindwasser, O Wolf, Myrehaug, Sten, Raj, Nitya P, Reidy-Lagunes, Diane L, Soares, Heloisa P, Strosberg, Jonathan R, Kohn, Elise C, Kunz, Pamela L

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Treatment Sequencing Strategies in Advanced Neuroendocrine Tumors: A Review von Chauhan, Aman, Del Rivero, Jaydira, Ramirez, Robert A, Soares, Heloisa P, Li, Daneng

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