Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition von MCCABE, Nuala, TURNER, Nicholas C, SMITH, Graeme C. M, ASHWORTH, Alan, LORD, Christopher J, KLUZEK, Katarzyna, BIALKOWSKA, Aneta, SWIFT, Sally, GIAVARA, Sabrina, O'CONNOR, Mark J, TUFT, Andrew N, ZDZIENICKA, Malgorzata Z

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AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity von CHRESTA, Christine M, DAVIES, Barry R, JAMES, Dominic, HOWARD, Zoe, DUDLEY, Phillippa, HUGHES, Gareth, SMITH, Lisa, MAGUIRE, Sharon, HUMMERSONE, Marc, MALAGU, Karine, MENEAR, Keith, JENKINS, Richard, HICKSON, Ian, JACOBSEN, Matt, SMITH, Graeme C. M, GUICHARD, Sylvie, PASS, Martin, HARDING, Tom, COSULICH, Sabina, CRITCHLOW, Susan E, VINCENT, John P, ELLSTON, Rebecca, JONES, Darren, SINI, Patrizia

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks von Jazayeri, Ali, Falck, Jacob, Lukas, Claudia, Bartek, Jiri, Smith, Graeme C. M., Lukas, Jiri, Jackson, Stephen P.

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy von Farmer, Hannah, McCabe, Nuala, Lord, Christopher J., Tutt, Andrew N. J., Johnson, Damian A., Richardson, Tobias B., Santarosa, Manuela, Dillon, Krystyna J., Hickson, Ian, Knights, Charlotte, Martin, Niall M. B., Jackson, Stephen P., Smith, Graeme C. M., Ashworth, Alan

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM von HICKSON, Ian, YAN ZHAO, RICHARDSON, Caroline J, GREEN, Sharon J, MARTIN, Niall M. B, ORR, Alisdair I, REAPER, Philip M, JACKSON, Stephen P, CURTIN, Nicola J, SMITH, Graeme C. M

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Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441 von YAN ZHAO, THOMAS, Huw D, BATEY, Michael A, COWELL, Ian G, RICHARDSON, Caroline J, GRIFFIN, Roger J, CALVERT, A. Hilary, NEWELL, David R, SMITH, Graeme C. M, CURTIN, Nicola J

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Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells von Rajendra, Eeson, Grande, Diego, Mason, Bethany, Di Marcantonio, Daniela, Armstrong, Lucy, Hewitt, Graeme, Elinati, Elias, Galbiati, Alessandro, Boulton, Simon J, Heald, Robert A, Smith, Graeme C M, Robinson, Helen M R

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4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1 von Menear, Keith A, Adcock, Claire, Boulter, Robert, Cockcroft, Xiao-ling, Copsey, Louise, Cranston, Aaron, Dillon, Krystyna J, Drzewiecki, Jan, Garman, Sheila, Gomez, Sylvie, Javaid, Hashim, Kerrigan, Frank, Knights, Charlotte, Lau, Alan, Loh, Vincent M, Matthews, Ian T. W, Moore, Stephen, O’Connor, Mark J, Smith, Graeme C. M, Martin, Niall M. B

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Functional and regulatory profiling of energy metabolism in fission yeast von Malecki, Michal, Bitton, Danny A, Rodríguez-López, Maria, Rallis, Charalampos, Calavia, Noelia Garcia, Smith, Graeme C, Bähler, Jürg

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AnGeLi: A Tool for the Analysis of Gene Lists from Fission Yeast von Bitton, Danny A, Schubert, Falk, Dey, Shoumit, Okoniewski, Michal, Smith, Graeme C, Khadayate, Sanjay, Pancaldi, Vera, Wood, Valerie, Bähler, Jürg

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Targeting the DNA double strand break repair machinery in prostate cancer von Shaheen, Fadhel S, Znojek, Pawel, Fisher, Ann, Webster, Martin, Plummer, Ruth, Gaughan, Luke, Smith, Graeme C M, Leung, Hing Y, Curtin, Nicola J, Robson, Craig N

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LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq von Bitton, Danny A, Rallis, Charalampos, Jeffares, Daniel C, Smith, Graeme C, Chen, Yuan Y C, Codlin, Sandra, Marguerat, Samuel, Bähler, Jürg

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Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K von Munck, Joanne M, Batey, Michael A, Zhao, Yan, Jenkins, Helen, Richardson, Caroline J, Cano, Celine, Tavecchio, Michele, Barbeau, Jody, Bardos, Julia, Cornell, Liam, Griffin, Roger J, Menear, Keith, Slade, Andrew, Thommes, Pia, Martin, Niall M B, Newell, David R, Smith, Graeme C M, Curtin, Nicola J

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Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase von Lau, Alan, Swinbank, Karra M., Ahmed, Parvin S., Taylor, Debra L., Jackson, Stephen P., Smith, Graeme C. M., O'Connor, Mark J.

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Poly(ADP-Ribose) Polymerase-1 Inhibitor Treatment Regresses Autochthonous Brca2/p53-Mutant Mammary Tumors In vivo and Delays Tumor Relapse in Combination with Carboplatin von HAY, Trevor, MATTHEW, James R, CLARKE, Alan R, PIETZKA, Lucie, LAU, Alan, CRANSTON, Aaron, NYGREN, Anders O. H, DOUGLAS-JONES, Anthony, SMITH, Graeme C. M, MARTIN, Niall M. B, O'CONNOR, Mark

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Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach von Hardcastle, Ian R, Cockcroft, Xiaoling, Curtin, Nicola J, El-Murr, Marine Desage, Leahy, Justin J. J, Stockley, Martin, Golding, Bernard T, Rigoreau, Laurent, Richardson, Caroline, Smith, Graeme C. M, Griffin, Roger J

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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells von Belan, Ondrej, Sebald, Marie, Adamowicz, Marek, Anand, Roopesh, Vancevska, Aleksandra, Neves, Joana, Grinkevich, Vera, Hewitt, Graeme, Segura-Bayona, Sandra, Bellelli, Roberto, Robinson, Helen M.R., Higgins, Geoff S., Smith, Graeme C.M., West, Stephen C., Rueda, David S., Boulton, Simon J.

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1‑Substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino‑4H‑chromen-4-ones Endowed with Dual DNA-PK/PI3‑K Inhibitory Activity von Cano, Céline, Saravanan, Kappusamy, Bailey, Chris, Bardos, Julia, Curtin, Nicola J, Frigerio, Mark, Golding, Bernard T, Hardcastle, Ian R, Hummersone, Marc G, Menear, Keith A, Newell, David R, Richardson, Caroline J, Shea, K, Smith, Graeme C. M, Thommes, Pia, Ting, Attilla, Griffin, Roger J

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Addressing the dauntingness of formulation: The value of considering empathy as “grasping” von Smith, Graeme C

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Selective Benzopyranone and Pyrimido[2,1-a]isoquinolin-4-one Inhibitors of DNA-Dependent Protein Kinase:  Synthesis, Structure−Activity Studies, and Radiosensitization of a Human T... von Griffin, Roger J, Fontana, Gabriele, Golding, Bernard T, Guiard, Sophie, Hardcastle, Ian R, Leahy, Justin J. J, Martin, Niall, Richardson, Caroline, Rigoreau, Laurent, Stockley, Martin, Smith, Graeme C. M

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