Equilibrium transport in double-diffusive convection von Radko, Timour, Smith, D. Paul

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Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer von Gogleva, Anna, Polychronopoulos, Dimitris, Pfeifer, Matthias, Poroshin, Vladimir, Ughetto, Michaël, Martin, Matthew J., Thorpe, Hannah, Bornot, Aurelie, Smith, Paul D., Sidders, Ben, Dry, Jonathan R., Ahdesmäki, Miika, McDermott, Ultan, Papa, Eliseo, Bulusu, Krishna C.

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MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy von Beloueche-Babari, Mounia, Wantuch, Slawomir, Casals Galobart, Teresa, Koniordou, Markella, Parkes, Harold G, Arunan, Vaitha, Chung, Yuen-Li, Eykyn, Thomas R, Smith, Paul D, Leach, Martin O

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Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity von Curtis, Nicola J, Mooney, Lorraine, Hopcroft, Lorna, Michopoulos, Filippos, Whalley, Nichola, Zhong, Haihong, Murray, Clare, Logie, Armelle, Revill, Mitchell, Byth, Kate F, Benjamin, Amanda D, Firth, Mike A, Green, Stephen, Smith, Paul D, Critchlow, Susan E

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Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers von Vaclova, Tereza, Grazini, Ursula, Ward, Lewis, O’Neill, Daniel, Markovets, Aleksandra, Huang, Xiangning, Chmielecki, Juliann, Hartmaier, Ryan, Thress, Kenneth S., Smith, Paul D., Barrett, J. Carl, Downward, Julian, de Bruin, Elza C.

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Basal and Treatment-Induced Activation of AKT Mediates Resistance to Cell Death by AZD6244 (ARRY-142886) in Braf-Mutant Human Cutaneous Melanoma Cells von VASHISHT GOPAL, Y. N, WANLENG DENG, WOODMAN, Scott E, KOMUROV, Kakajan, RAM, Prahlad, SMITH, Paul D, DAVIES, Michael A

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Drug Sensitivity and Allele Specificity of First-Line Osimertinib Resistance EGFR Mutations von Starrett, Jacqueline H., Guernet, Alexis A., Cuomo, Maria Emanuela, Poels, Kamrine E., van Rosenburgh, Iris K. van Alderwerelt, Nagelberg, Amy, Farnsworth, Dylan, Price, Kristin S., Khan, Hina, Ashtekar, Kumar Dilip, Gaefele, Mmaserame, Ayeni, Deborah, Stewart, Tyler F., Kuhlmann, Alexandra, Kaech, Susan M., Unni, Arun M., Homer, Robert, Lockwood, William W., Michor, Franziska, Goldberg, Sarah B., Lemmon, Mark A., Smith, Paul D., Cross, Darren A. E., Politi, Katerina

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Antitumor activity in RAS-driven tumors by blocking AKT and MEK von Tolcher, Anthony W, Khan, Khurum, Ong, Michael, Banerji, Udai, Papadimitrakopoulou, Vassiliki, Gandara, David R, Patnaik, Amita, Baird, Richard D, Olmos, David, Garrett, Christopher R, Skolnik, Jeffrey M, Rubin, Eric H, Smith, Paul D, Huang, Pearl, Learoyd, Maria, Shannon, Keith A, Morosky, Anne, Tetteh, Ernestina, Jou, Ying-Ming, Papadopoulos, Kyriakos P, Moreno, Victor, Kaiser, Brianne, Yap, Timothy A, Yan, Li, de Bono, Johann S

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Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors von Sale, Matthew J., Minihane, Emma, Monks, Noel R., Gilley, Rebecca, Richards, Frances M., Schifferli, Kevin P., Andersen, Courtney L., Davies, Emma J., Vicente, Mario Aladren, Ozono, Eiko, Markovets, Aleksandra, Dry, Jonathan R., Drew, Lisa, Flemington, Vikki, Proia, Theresa, Jodrell, Duncan I., Smith, Paul D., Cook, Simon J.

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MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model von Bartholomeusz, Chandra, Xie, Xuemei, Pitner, Mary Kathryn, Kondo, Kimie, Dadbin, Ali, Lee, Jangsoon, Saso, Hitomi, Smith, Paul D, Dalby, Kevin N, Ueno, Naoto T

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Anti-PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC von Tu, Eric, McGlinchey, Kelly, Wang, Jixin, Martin, Philip, Ching, Steven Lk, Floc'h, Nicolas, Kurasawa, James, Starrett, Jacqueline H, Lazdun, Yelena, Wetzel, Leslie, Nuttall, Barrett, Ng, Felicia Sl, Coffman, Karen T, Smith, Paul D, Politi, Katerina, Cooper, Zachary A, Streicher, Katie

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Q Factor Enhancement of Open 2D Resonators by Optimal Placement of a Thin Metallic Rod in Front of the Longitudinal Slot von Vinogradova, Elena D., Smith, Paul D.

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Challenges and Opportunities in Cancer Drug Resistance von Ward, Richard A, Fawell, Stephen, Floc’h, Nicolas, Flemington, Vikki, McKerrecher, Darren, Smith, Paul D

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Transcriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244) von DRY, Jonathan R, PAVEY, Sandra, GRAHAM, Alexander, BERAN, Garry, CASSIDY, Andrew, HAGGERTY, Carolyn, BROWN, Helen, ELLISON, Gillian, DERING, Judy, TAYLOR, Barry S, STARK, Mitchell, BONAZZI, Vanessa, PRATILAS, Christine A, RAVISHANKAR, Sugandha, PACKER, Leisl, FENG XING, SOLIT, David B, FINN, Richard S, ROSEN, Neal, HAYWARD, Nicholas K, FRENCH, Tim, SMITH, Paul D, HARBRON, Chris, RUNSWICK, Sarah, HODGSON, Darren, CHRESTA, Christine, MCCORMACK, Rose, BYRNE, Natalie, COCKERILL, Mark

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RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K‐RAS mutant tumors von Yuan, Xi, Tang, Zhiyu, Du, Rong, Yao, Zhan, Cheung, Shing‐Hu, Zhang, Xinwen, Wei, Jing, Zhao, Yuan, Du, Yunguang, Liu, Ye, Hu, Xiaoxia, Gong, Wenfeng, Liu, Yong, Gao, Yajuan, Huang, Zhiyue, Cao, Zongfu, Wei, Min, Zhou, Changyou, Wang, Lai, Rosen, Neal, Smith, Paul D., Luo, Lusong

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A cross sectional study to ascertain the incidence and causes of failure of oxygen delivery via Hudson Mask during recovery after anaesthesia von Matusik, Matthew, Smith, Paul D

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Reducing prescribing of antibiotics for acute respiratory infections using a frontline nurse-led EHR-Integrated clinical decision support tool: protocol for a stepped wedge randomi... von Stevens, Elizabeth R, Agbakoba, Ruth, Mann, Devin M, Hess, Rachel, Richardson, Safiya I, McGinn, Thomas, Smith, Paul D, Halm, Wendy, Mundt, Marlon P, Dauber-Decker, Katherine L, Jones, Simon A, Feldthouse, Dawn M, Kim, Eun Ji, Feldstein, David A

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BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins von Friday, Bret B, Yu, Chunrong, Dy, Grace K, Smith, Paul D, Wang, Liang, Thibodeau, Stephen N, Adjei, Alex A

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Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055) von HOLT, Sarah V, LOGIE, Armelle, WILKINSON, Robert W, GUICHARD, Sylvie M, SMITH, Paul D, DAVIES, Barry R, ALFEREZ, Denis, RUNSWICK, Sarah, FENTON, Sarah, CHRESTA, Christine M, YI GU, JINGCHUAN ZHANG, WU, Yi-Long

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The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells von Criscione, Steven W., Martin, Matthew J., Oien, Derek B., Gorthi, Aparna, Miragaia, Ricardo J., Zhang, Jingwen, Chen, Huawei, Karl, Daniel L., Mendler, Kerrin, Markovets, Aleksandra, Gagrica, Sladjana, Delpuech, Oona, Dry, Jonathan R., Grondine, Michael, Hattersley, Maureen M., Urosevic, Jelena, Floc’h, Nicolas, Drew, Lisa, Yao, Yi, Smith, Paul D.

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