APJ acts as a dual receptor in cardiac hypertrophy von Scimia, Maria Cecilia, Hurtado, Cecilia, Ray, Saugata, Metzler, Scott, Wei, Ke, Wang, Jianming, Woods, Chris E., Purcell, Nicole H., Catalucci, Daniele, Akasaka, Takeshi, Bueno, Orlando F., Vlasuk, George P., Kaliman, Perla, Bodmer, Rolf, Smith, Layton H., Ashley, Euan, Mercola, Mark, Brown, Joan Heller, Ruiz-Lozano, Pilar

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Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11 von Li, Jing, Yakushi, Tanya, Parlati, Francesco, Mackinnon, Andrew L, Perez, Christian, Ma, Yuyong, Carter, Kyle P, Colayco, Sharon, Magnuson, Gavin, Brown, Brock, Nguyen, Kevin, Vasile, Stefan, Suyama, Eigo, Smith, Layton H, Sergienko, Eduard, Pinkerton, Anthony B, Chung, Thomas D Y, Palmer, Amy E, Pass, Ian, Hess, Sonja, Cohen, Seth M, Deshaies, Raymond J

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Downregulation of the Apelinergic Axis Accelerates Aging, whereas Its Systemic Restoration Improves the Mammalian Healthspan von Rai, Rahul, Ghosh, Asish K., Eren, Mesut, Mackie, Alexander R., Levine, Daniel C., Kim, So-Youn, Cedernaes, Jonathan, Ramirez, Veronica, Procissi, Daniele, Smith, Layton H., Woodruff, Teresa K., Bass, Joseph, Vaughan, Douglas E.

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Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators von Pinkerton, Anthony B., Sessions, E. Hampton, Hershberger, Paul, Maloney, Patrick R., Peddibhotla, Satyamaheshwar, Hopf, Meghan, Sergienko, Eduard, Ma, Chen-Ting, Smith, Layton H., Jackson, Michael R., Tanaka, Jun, Tsuji, Takashi, Akiu, Mayuko, Cohen, Steven E., Nakamura, Tsuyoshi, Gardell, Stephen J.

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Apelin protects against angiotensin II-induced cardiovascular fibrosis and decreases plasminogen activator inhibitor type-1 production von Siddiquee, Khandaker, Hampton, Jessica, Khan, Susan, Zadory, Dan, Gleaves, Linda, Vaughan, Douglas E, Smith, Layton H

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Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization von McAnally, Danielle, Siddiquee, Khandaker, Gomaa, Ahmed, Szabo, Andras, Vasile, Stefan, Maloney, Patrick R, Divlianska, Daniela B, Peddibhotla, Satyamaheshwar, Morfa, Camilo J, Hershberger, Paul, Falter, Rebecca, Williamson, Robert, Terry, David B, Farjo, Rafal, Pinkerton, Anthony B, Qi, Xiaping, Quigley, Judith, Boulton, Michael E, Grant, Maria B, Smith, Layton H

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Design and Synthesis of Systemically Active Metabotropic Glutamate Subtype‑2 and -3 (mGlu2/3) Receptor Positive Allosteric Modulators (PAMs): Pharmacological Characterization and A... von Dhanya, Raveendra-Panickar, Sheffler, Douglas J, Dahl, Russell, Davis, Melinda, Lee, Pooi San, Yang, Li, Nickols, Hilary Highfield, Cho, Hyekyung P, Smith, Layton H, D’Souza, Manoranjan S, Conn, P. Jeffrey, Der-Avakian, Andre, Markou, Athina, Cosford, Nicholas D. P

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Image Analysis Algorithms for Immunohistochemical Assessment of Cell Death Events and Fibrosis in Tissue Sections von Krajewska, Maryla, Smith, Layton H, Rong, Juan, Huang, Xianshu, Hyer, Marc L, Zeps, Nikolajs, Iacopetta, Barry, Linke, Steven P, Olson, Allen H, Reed, John C, Krajewski, Stan

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Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor von Maloney, Patrick R., Khan, Pasha, Hedrick, Michael, Gosalia, Palak, Milewski, Monika, Li, Linda, Roth, Gregory P., Sergienko, Eduard, Suyama, Eigo, Sugarman, Eliot, Nguyen, Kevin, Mehta, Alka, Vasile, Stefan, Su, Ying, Stonich, Derek, Nguyen, Hung, Zeng, Fu-Yue, Novo, Arianna Mangravita, Vicchiarelli, Michael, Diwan, Jena, Chung, Thomas D.Y., Smith, Layton H., Pinkerton, Anthony B.

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Potent, Selective, and Orally Available Benzoisothiazolone Phosphomannose Isomerase Inhibitors as Probes for Congenital Disorder of Glycosylation Ia von Dahl, Russell, Bravo, Yalda, Sharma, Vandana, Ichikawa, Mie, Dhanya, Raveendra-Panickar, Hedrick, Michael, Brown, Brock, Rascon, Justin, Vicchiarelli, Michael, Mangravita-Novo, Arianna, Yang, Li, Stonich, Derek, Su, Ying, Smith, Layton H, Sergienko, Eduard, Freeze, Hudson H, Cosford, Nicholas D. P

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Orally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure–Activity Relationships and Assessment in a Rat Model of Nicotine Dependence von Sidique, Shyama, Dhanya, Raveendra-Panickar, Sheffler, Douglas J, Nickols, Hilary Highfield, Yang, Li, Dahl, Russell, Mangravita-Novo, Arianna, Smith, Layton H, D’Souza, Manoranjan S, Semenova, Svetlana, Conn, P. Jeffrey, Markou, Athina, Cosford, Nicholas D. P

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Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein von Haass-Koffler, Carolina L., Francis, T. Chase, Gandhi, Pauravi, Patel, Reesha, Naemuddin, Mohammad, Nielsen, Carsten K., Bartlett, Selena E., Bonci, Antonello, Vasile, Stefan, Hood, Becky L., Suyama, Eigo, Hedrick, Michael P., Smith, Layton H., Limpert, Allison S., Roberto, Marisa, Cosford, Nicholas D.P., Sheffler, Douglas J.

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Plasminogen Activator Inhibitor-1 Antagonist TM5441 Attenuates Nω-Nitro-L-Arginine Methyl Ester–Induced Hypertension and Vascular Senescence von Boe, Amanda E, Eren, Mesut, Murphy, Sheila B, Kamide, Christine E, Ichimura, Atsuhiko, Terry, David, McAnally, Danielle, Smith, Layton H, Miyata, Toshio, Vaughan, Douglas E

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Concentration and proteolysis of CX3CL1 may regulate the microglial response to CX3CL1 von Finneran, Dylan, Li, Qingyou, Subbarayan, Meena S., Joly‐Amado, Aurelie, Kamath, Siddharth, Dengler, Daniela G., Gordon, Marcia N., Jackson, Michael R., Morgan, Dave, Bickford, Paula C., Smith, Layton H., Nash, Kevin R.

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Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis von Smith, Layton H., Dixon, John D., Stringham, John R., Eren, Mesut, Elokdah, Hassan, Crandall, Dave L., Washington, Kay, Vaughan, Douglas E.

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Targeting the IRE1α/XBP1 and ATF6 Arms of the Unfolded Protein Response Enhances VEGF Blockade to Prevent Retinal and Choroidal Neovascularization von Liu, Li, Qi, Xiaoping, Chen, Zhijuan, Shaw, Lynn, Cai, Jun, Smith, Layton H, Grant, Maria B, Boulton, Michael E

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Discovery of β‑Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators von Pinkerton, Anthony B, Peddibhotla, Satyamaheshwar, Yamamoto, Fusayo, Slosky, Lauren M, Bai, Yushi, Maloney, Patrick, Hershberger, Paul, Hedrick, Michael P, Falter, Bekhi, Ardecky, Robert J, Smith, Layton H, Chung, Thomas D. Y, Jackson, Michael R, Caron, Marc G, Barak, Lawrence S

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Discovery of Novel Small-Molecule Inducers of Heme Oxygenase-1 That Protect Human iPSC-Derived Cardiomyocytes from Oxidative Stress von Kirby, R. Jason, Divlianska, Daniela B., Whig, Kanupriya, Bryan, Nadezda, Morfa, Camilo J., Koo, Ada, Hood, Becky L., Nguyen, Kevin H., Maloney, Patrick, Peddibhotla, Satayamaheshwar, Sessions, E. Hampton, Hershberger, Paul M., Smith, Layton H., Malany, Siobhan

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Discovery of small molecule antagonists of chemokine receptor CXCR6 that arrest tumor growth in SK-HEP-1 mouse xenografts as a model of hepatocellular carcinoma von Peddibhotla, Satyamaheshwar, Hershberger, Paul M., Jason Kirby, R., Sugarman, Eliot, Maloney, Patrick R., Hampton Sessions, E., Divlianska, Daniela, Morfa, Camilo J., Terry, David, Pinkerton, Anthony B., Smith, Layton H., Malany, Siobhan

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Novel and Structurally Diversified Bacterial DNA Gyrase Inhibitors Discovered through a Fluorescence-Based High-Throughput Screening Assay von Alfonso, Eddy E., Deng, Zifang, Boaretto, Daniel, Hood, Becky L., Vasile, Stefan, Smith, Layton H., Chambers, Jeremy W., Chapagain, Prem, Leng, Fenfei

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