Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human von Basit, Abdul, Neradugomma, Naveen K, Wolford, Christopher, Fan, Peter W, Murray, Bernard, Takahashi, Ryan H, Khojasteh, S. Cyrus, Smith, Bill J, Heyward, Scott, Totah, Rheem A, Kelly, Edward J, Prasad, Bhagwat

Volltext

Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells von Li, Ruidong, Liclican, Albert, Xu, Yili, Pitts, Jared, Niu, Congrong, Zhang, Jingyu, Kim, Cynthia, Zhao, Xiaofeng, Soohoo, Daniel, Babusis, Darius, Yue, Qin, Ma, Bin, Murray, Bernard P, Subramanian, Raju, Xie, Xuping, Zou, Jing, Bilello, John P, Li, Li, Schultz, Brian E, Sakowicz, Roman, Smith, Bill J, Shi, Pei-Yong, Murakami, Eisuke, Feng, Joy Y

Volltext

Prediction of Drug-Drug Interactions with Crizotinib as the CYP3A Substrate Using a Physiologically Based Pharmacokinetic Model von Yamazaki, Shinji, Johnson, Theodore R, Smith, Bill J

Volltext

Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small Intestine von Zhang, Haeyoung, Wolford, Chris, Basit, Abdul, Li, Albert P., Fan, Peter W., Murray, Bernard P., Takahashi, Ryan H., Khojasteh, S. Cyrus, Smith, Bill J., Thummel, Kenneth E., Prasad, Bhagwat

Volltext

Characterization of Seasonal Pharmacokinetic Variability in Woodchucks von Zheng, Jim, Balsitis, Scott, Santos, Rex, Smith, Bill J., Subramanian, Raju

Volltext

Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species von Basit, Abdul, Fan, Peter W, Khojasteh, S Cyrus, Murray, Bernard P, Smith, Bill J, Heyward, Scott, Prasad, Bhagwat

Volltext

18O‑Enabled High-Throughput Acyl Glucuronide Stability Assay von Yu, Zaikuan Josh, Le, Hoa, Tang, Jennifer, Yue, Qin, Zhang, Jingyu, Murray, Bernard, Liu, Xingrong, Smith, Bill J., Subramanian, Raju

Volltext

Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches von Hosea, Natilie A., Collard, Wendy T., Cole, Susan, Maurer, Tristan S., Fang, Rick X., Jones, Hannah, Kakar, Shefali M., Nakai, Yasuhiro, Smith, Bill J., Webster, Rob, Beaumont, Kevin

Volltext

Social cognitive determinants of nutrition and physical activity among web-health users enrolling in an online intervention: the influence of social support, self-efficacy, outcome... von Anderson-Bill, Eileen Smith, Winett, Richard A, Wojcik, Janet R

Volltext

Transporter Gene Regulation in Sandwich Cultured Human Hepatocytes Through the Activation of Constitutive Androstane Receptor (CAR) or Aryl Hydrocarbon Receptor (AhR) von Niu, Congrong, Smith, Bill, Lai, Yurong

Volltext

Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretrovira... von Subramanian, Raju, Tang, Jennifer, Zheng, Jim, Lu, Bing, Wang, Kelly, Yant, Stephen R, Stepan, George J, Mulato, Andrew, Yu, Helen, Schroeder, Scott, Shaik, Naveed, Singh, Renu, Wolckenhauer, Scott, Chester, Anne, Tse, Winston C, Chiu, Anna, Rhee, Martin, Cihlar, Tomas, Rowe, William, Smith, Bill J

Volltext

Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs von Subash, Sandhya, Singh, Dilip K, Ahire, Deepak S, Khojasteh, S Cyrus, Murray, Bernard P, Zientek, Michael A, Jones, Robert S, Kulkarni, Priyanka, Smith, Bill J, Heyward, Scott, Cronin, Ciarán N, Prasad, Bhagwat

Volltext

Ontogeny of Human Liver Aldehyde Oxidase: Developmental Changes and Implications for Drug Metabolism von Subash, Sandhya, Singh, Dilip K., Ahire, Deepak, Khojasteh, S. Cyrus, Murray, Bernard P., Zientek, Michael A., Jones, Robert S., Kulkarni, Priyanka, Zubair, Faizan, Smith, Bill J., Heyward, Scott, Leeder, J. Steven, Prasad, Bhagwat

Volltext

Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite—Resolution for Clinical Development von Zheng, Jim, Xin, Yan, Zhang, Jingyu, Subramanian, Raju, Murray, Bernard P., Whitney, J. Andrew, Warr, Matthew R., Ling, John, Moorehead, Lisa, Kwan, Ellen, Hemenway, Jeffrey, Smith, Bill J., Silverman, Jeffrey A.

Volltext

Pharmacokinetic/pharmacodynamic modeling of crizotinib for anaplastic lymphoma kinase inhibition and antitumor efficacy in human tumor xenograft mouse models von Yamazaki, Shinji, Vicini, Paolo, Shen, Zhongzhou, Zou, Helen Y, Lee, Joseph, Li, Qiuhua, Christensen, James G, Smith, Bill J, Shetty, Bhasker

Volltext

Intravenous delivery of GS-441524 is efficacious in the African green monkey model of SARS-CoV-2 infection von Pitts, Jared, Babusis, Darius, Vermillion, Meghan S., Subramanian, Raju, Barrett, Kim, Lye, Diane, Ma, Bin, Zhao, Xiaofeng, Riola, Nicholas, Xie, Xuping, Kajon, Adriana, Lu, Xianghan, Bannister, Roy, Shi, Pei-Yong, Toteva, Maria, Porter, Danielle P., Smith, Bill J., Cihlar, Tomas, Mackman, Richard, Bilello, John P.

Volltext

Application of target-mediated drug disposition model to small molecule heat shock protein 90 inhibitors von Yamazaki, Shinji, Shen, Zhongzhou, Jiang, Ying, Smith, Bill J, Vicini, Paolo

Volltext

Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human von Warren, Mark S., Zerangue, Noa, Woodford, Katie, Roberts, Lori M., Tate, Emily H., Feng, Bo, Li, Cheryl, Feuerstein, Thomas J., Gibbs, John, Smith, Bill, de Morais, Sonia M., Dower, William J., Koller, Kerry J.

Volltext

In Vitro Kinetic Characterization of Axitinib Metabolism von Zientek, Michael A, Goosen, Theunis C, Tseng, Elaine, Lin, Jian, Bauman, Jonathan N, Walker, Gregory S, Kang, Ping, Jiang, Ying, Freiwald, Sascha, Neul, David, Smith, Bill J

Volltext

Pharmacokinetics, metabolism, and excretion of [14C]axitinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in humans von Smith, Bill J, Pithavala, Yazdi, Bu, Hai-Zhi, Kang, Ping, Hee, Brian, Deese, Alan J, Pool, William F, Klamerus, Karen J, Wu, Ellen Y, Dalvie, Deepak K

Volltext