Polycyclic xanthone natural products: structure, biological activity and chemical synthesis von Winter, Dana K, Sloman, David L, Porco Jr, John A

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Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors von Pu, Qinglin, Zhang, Hongjun, Guo, Liangqin, Cheng, Mangeng, Doty, Amy C, Ferguson, Heidi, Fradera, Xavier, Lesburg, Charles A, McGowan, Meredeth A, Miller, J. Richard, Geda, Prasanthi, Song, Xuelei, Otte, Karin, Sciammetta, Nunzio, Solban, Nicolas, Yu, Wensheng, Sloman, David L, Zhou, Hua, Lammens, Alfred, Neumann, Lars, Bennett, David Jonathan, Pasternak, Alexander, Han, Yongxin

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Total Synthesis and Absolute Stereochemical Assignment of Kibdelone C von Sloman, David L, Bacon, Jeffrey W, Porco, John A

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A Selective Synthesis of 2,2-Difluorobicyclo[1.1.1]pentane Analogues: "BCP-F 2 " von Ma, Xiaoshen, Sloman, David L, Han, Yongxin, Bennett, David J

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Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells von Wang, Yun, Cui, Long, Georgiev, Peter, Singh, Latika, Zheng, Yanyan, Yu, Ying, Grein, Jeff, Zhang, Chunsheng, Muise, Eric S., Sloman, David L., Ferguson, Heidi, Yu, Hongshi, Pierre, Cristina St, Dakle, Pranal J, Pucci, Vincenzo, Baker, James, Loboda, Andrey, Linn, Doug, Brynczka, Christopher, Wilson, Doug, Haines, Brian B, Long, Brian, Wnek, Richard, Sadekova, Svetlana, Rosenzweig, Michael, Haidle, Andrew, Han, Yongxin, Ranganath, Sheila H.

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Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones von Sloman, David L, Mitasev, Branko, Scully, Stephen S, Beutler, John A, Porco, John A. Jr

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A Selective Synthesis of 2,2-Difluorobicyclo[1.1.1]pentane Analogues: “BCP‑F2” von Ma, Xiaoshen, Sloman, David L, Han, Yongxin, Bennett, David J

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Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRASG12C Inhibitor von Ma, Xiaoshen, Sloman, David L., Duggal, Ruchia, Anderson, Kenneth D., Ballard, Jeanine E., Bharathan, Indu, Brynczka, Christopher, Gathiaka, Symon, Henderson, Timothy J., Lyons, Thomas W., Miller, Richard, Munsell, Erik V., Orth, Peter, Otte, Ryan D., Palani, Anandan, Rankic, Danica A., Robinson, Michelle R., Sather, Aaron C., Solban, Nicolas, Song, Xuelei Sherry, Wen, Xin, Xu, Zangwei, Yang, Yi, Yang, Ruojing, Day, Phil J., Stoeck, Alexander, Bennett, David Jonathan, Han, Yongxin

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Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist von Balıkçı, Esra, Marques, Anne-Sophie M. C., Bauer, Ludwig G., Seupel, Raina, Bennett, James, Raux, Brigitt, Buchan, Karly, Simelis, Klemensas, Singh, Usha, Rogers, Catherine, Ward, Jennifer, Cheng, Carol, Szommer, Tamas, Schützenhofer, Kira, Elkins, Jonathan M., Sloman, David L., Ahel, Ivan, Fedorov, Oleg, Brennan, Paul E., Huber, Kilian V. M.

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Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRAS G12C Inhibitor von Ma, Xiaoshen, Sloman, David L, Duggal, Ruchia, Anderson, Kenneth D, Ballard, Jeanine E, Bharathan, Indu, Brynczka, Christopher, Gathiaka, Symon, Henderson, Timothy J, Lyons, Thomas W, Miller, Richard, Munsell, Erik V, Orth, Peter, Otte, Ryan D, Palani, Anandan, Rankic, Danica A, Robinson, Michelle R, Sather, Aaron C, Solban, Nicolas, Song, Xuelei Sherry, Wen, Xin, Xu, Zangwei, Yang, Yi, Yang, Ruojing, Day, Phil J, Stoeck, Alexander, Bennett, David Jonathan, Han, Yongxin

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Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing von Li, Derun, Sloman, David L, Achab, Abdelghani, Zhou, Hua, McGowan, Meredeth A, White, Catherine, Gibeau, Craig, Zhang, Hongjun, Pu, Qinglin, Bharathan, Indu, Hopkins, Brett, Liu, Kun, Ferguson, Heidi, Fradera, Xavier, Lesburg, Charles A, Martinot, Theodore A, Qi, Ji, Song, Zhiguo J, Yin, Jingjun, Zhang, Huangguang, Song, Licheng, Wan, Baoqiang, DAddio, Suzanne, Solban, Nicolas, Miller, J Richard, Zamlynny, Beata, Bass, Alan, Freeland, Elizabeth, Ykoruk, Bridget, Hilliard, Catherine, Ferraro, Jude, Zhai, Jin, Knemeyer, Ian, Otte, Karin M, Vincent, Stella, Sciammetta, Nunzio, Pasternak, Alexander, Bennett, David Jonathan, Han, Yongxin

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The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors von Hamblett, Christopher L., Methot, Joey L., Mampreian, Dawn M., Sloman, David L., Stanton, Matthew G., Kral, Astrid M., Fleming, Judith C., Cruz, Jonathan C., Chenard, Melissa, Ozerova, Nicole, Hitz, Anna M., Wang, Hongmei, Deshmukh, Sujal V., Nazef, Naim, Harsch, Andreas, Hughes, Bethany, Dahlberg, William K., Szewczak, Alex A., Middleton, Richard E., Mosley, Ralph T., Secrist, J. Paul, Miller, Thomas A.

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Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology von Lu, Min, Zhang, Hongjun, Li, Derun, Childers, Matthew, Pu, Qinglin, Palte, Rachel L, Gathiaka, Symon, Lyons, Thomas W, Palani, Anandan, Fan, Peter W, Spacciapoli, Peter, Miller, J. Richard, Cho, Hyelim, Cheng, Mangeng, Chakravarthy, Kalyan, O’Neil, Jennifer, Eangoor, Padmanabhan, Beard, Adam, Kim, Hai-Young, Saurí, Josep, Gunaydin, Hakan, Sloman, David L, Siliphaivanh, Phieng, Cumming, Jared, Fischer, Christian

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Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy von Mitcheltree, Matthew J, Li, Derun, Achab, Abdelghani, Beard, Adam, Chakravarthy, Kalyan, Cheng, Mangeng, Cho, Hyelim, Eangoor, Padmanabhan, Fan, Peter, Gathiaka, Symon, Kim, Hai-Young, Lesburg, Charles A, Lyons, Thomas W, Martinot, Theodore A, Miller, J. Richard, McMinn, Spencer, O’Neil, Jennifer, Palani, Anandan, Palte, Rachel L, Saurí, Josep, Sloman, David L, Zhang, Hongjun, Cumming, Jared N, Fischer, Christian

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Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors von Li, Derun, Zhang, Hongjun, Lyons, Thomas W, Lu, Min, Achab, Abdelghani, Pu, Qinglin, Childers, Matthew, Mitcheltree, Matthew J, Wang, Jialiang, Martinot, Theodore A, McMinn, Spencer E, Sloman, David L, Palani, Anandan, Beard, Adam, Nogle, Lisa, Gathiaka, Symon, Saurí, Josep, Kim, Hai-Young, Adpressa, Donovon, Spacciapoli, Peter, Miller, J. Richard, Palte, Rachel L, Lesburg, Charles A, Cumming, Jared, Fischer, Christian

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Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2) von Methot, Joey L., Chakravarty, Prasun K., Chenard, Melissa, Close, Joshua, Cruz, Jonathan C., Dahlberg, William K., Fleming, Judith, Hamblett, Christopher L., Hamill, Julie E., Harrington, Paul, Harsch, Andreas, Heidebrecht, Richard, Hughes, Bethany, Jung, Joon, Kenific, Candia M., Kral, Astrid M., Meinke, Peter T., Middleton, Richard E., Ozerova, Nicole, Sloman, David L., Stanton, Matthew G., Szewczak, Alexander A., Tyagarajan, Sriram, Witter, David J., Paul Secrist, J., Miller, Thomas A.

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Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors von Huang, Chunhui, Fischer, Christian, Machacek, Michelle R, Bogen, Stephane, Biftu, Tesfaye, Huang, Xianhai, Reutershan, Michael H, Otte, Ryan, Hong, Qingmei, Wu, Zhicai, Yu, Yang, Park, Min, Chen, Lei, Biju, Purakkattle, Knemeyer, Ian, Lu, Ping, Kochansky, Christopher J, Hicks, Michael Brendan, Liu, Yong, Helmy, Roy, Fradera, Xavier, Donofrio, Anthony, Close, Josh, Maddess, Matthew L, White, Catherine, Sloman, David L, Sciammetta, Nunzio, Lu, Jun, Gibeau, Craig, Simov, Vladimir, Zhang, Hongjun, Fuller, Peter, Witter, David

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Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties von Sloman, David L., Noucti, Njamkou, Altman, Michael D., Chen, Dapeng, Mislak, Andrea C., Szewczak, Alexander, Hayashi, Mansuo, Warren, Lee, Dellovade, Tammy, Wu, Zhenhua, Marcus, Jacob, Walker, Deborah, Su, Hua-Poo, Edavettal, Suzanne C., Munshi, Sanjeev, Hutton, Michael, Nuthall, Hugh, Stanton, Matthew G.

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Combination of EP 4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells von Wang, Yun, Cui, Long, Georgiev, Peter, Singh, Latika, Zheng, Yanyan, Yu, Ying, Grein, Jeff, Zhang, Chunsheng, Muise, Eric S, Sloman, David L, Ferguson, Heidi, Yu, Hongshi, Pierre, Cristina St, Dakle, Pranal J, Pucci, Vincenzo, Baker, James, Loboda, Andrey, Linn, Doug, Brynczka, Christopher, Wilson, Doug, Haines, Brian B, Long, Brian, Wnek, Richard, Sadekova, Svetlana, Rosenzweig, Michael, Haidle, Andrew, Han, Yongxin, Ranganath, Sheila H

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Synthetic Studies of 2,2‐Difluorobicyclo[1.1.1]pentanes (BCP‐F2): The Scope and Limitation of Useful Building Blocks for Medicinal Chemists von Ma, Xiaoshen, Pinto, Wilfredo, Pham, Luu N., Sloman, David L., Han, Yongxin

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