Site-specific characterization of endogenous SUMOylation across species and organs von Hendriks, Ivo A., Lyon, David, Su, Dan, Skotte, Niels H., Daniel, Jeremy A., Jensen, Lars J., Nielsen, Michael L.

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Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease von Andersen, Jens V., Skotte, Niels H., Christensen, Sofie K., Polli, Filip S., Shabani, Mohammad, Markussen, Kia H., Haukedal, Henriette, Westi, Emil W., Diaz-delCastillo, Marta, Sun, Ramon C., Kohlmeier, Kristi A., Schousboe, Arne, Gentry, Matthew S., Tanila, Heikki, Freude, Kristine K., Aldana, Blanca I., Mann, Matthias, Waagepetersen, Helle S.

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Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington’s disease von Mullari, Meeli, Fossat, Nicolas, Skotte, Niels H., Asenjo-Martinez, Andrea, Humphreys, David T., Bukh, Jens, Kirkeby, Agnete, Scheel, Troels K. H., Nielsen, Michael L.

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Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients von Skotte, Niels H, Southwell, Amber L, Østergaard, Michael E, Carroll, Jeffrey B, Warby, Simon C, Doty, Crystal N, Petoukhov, Eugenia, Vaid, Kuljeet, Kordasiewicz, Holly, Watt, Andrew T, Freier, Susan M, Hung, Gene, Seth, Punit P, Bennett, C Frank, Swayze, Eric E, Hayden, Michael R

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In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides von Southwell, Amber L, Skotte, Niels H, Kordasiewicz, Holly B, Østergaard, Michael E, Watt, Andrew T, Carroll, Jeffrey B, Doty, Crystal N, Villanueva, Erika B, Petoukhov, Eugenia, Vaid, Kuljeet, Xie, Yuanyun, Freier, Susan M, Swayze, Eric E, Seth, Punit P, Bennett, Clarence Frank, Hayden, Michael R

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HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response von Rotblat, Barak, Southwell, Amber L., Ehrnhoefer, Dagmar E., Skotte, Niels H., Metzler, Martina, Franciosi, Sonia, Leprivier, Gabriel, Somasekharan, Syam Prakash, Barokas, Adi, Yu Deng, Tang, Tiffany, Mathers, Joan, Cetinbas, Naniye, Daugaard, Mads, Kwok, Brian, Li, Liheng, Carnie, Christopher J., Fink, Dieter, Nitsch, Roberto, Galpin, Jason D., Ahern, Christopher A., Melino, Gerry, Penninger, Josef M., Hayden, Michael R., Sorensen, Poul H.

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Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease von Ehrnhoefer, Dagmar E, Martin, Dale D O, Schmidt, Mandi E, Qiu, Xiaofan, Ladha, Safia, Caron, Nicholas S, Skotte, Niels H, Nguyen, Yen T N, Vaid, Kuljeet, Southwell, Amber L, Engemann, Sabine, Franciosi, Sonia, Hayden, Michael R

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Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice von URIBE, Valeria, WONG, Bibiana K. Y, YU DENG, FRANCIOSI, Sonia, BISSADA, Nagat, SPREEUW, Amanda, WEINING ZHANG, EHRNHOEFER, Dagmar E, VAID, Kuljeet, MILLER, Freda D, DESHMUKH, Mohanish, HOWLAND, David, GRAHAM, Rona K, HARDEN, Michael R, CUSACK, Corey L, SKOTTE, Niels H, POULADI, Mahmoud A, YUANYUN XIE, FEINBERG, Konstantin, YIMIAO OU, YINGBIN OUYANG

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Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS von Østergaard, Michael E., Southwell, Amber L., Kordasiewicz, Holly, Watt, Andrew T., Skotte, Niels H., Doty, Crystal N., Vaid, Kuljeet, Villanueva, Erika B., Swayze, Eric E., Frank Bennett, C., Hayden, Michael R., Seth, Punit P.

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A quantitative method for the specific assessment of caspase-6 activity in cell culture von Ehrnhoefer, Dagmar E, Skotte, Niels H, Savill, Jane, Nguyen, Yen T N, Ladha, Safia, Cao, Li-Ping, Dullaghan, Edie, Hayden, Michael R

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Deletion of CaMKIIα disrupts glucose metabolism, glutamate uptake, and synaptic energetics in the cerebral cortex von Andersen, Jens V., Westi, Emil W., Griem‐Krey, Nane, Skotte, Niels H., Schousboe, Arne, Aldana, Blanca I., Wellendorph, Petrine

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Reduced gluconeogenesis and lactate clearance in Huntington's disease von Josefsen, Knud, Nielsen, Signe M.B, Campos, André, Seifert, Thomas, Hasholt, Lis, Nielsen, Jørgen E, Nørremølle, Anne, Skotte, Niels H, Secher, Niels H, Quistorff, Bjørn

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Integrative Characterization of the R6/2 Mouse Model of Huntington’s Disease Reveals Dysfunctional Astrocyte Metabolism von Skotte, Niels H., Andersen, Jens V., Santos, Alberto, Aldana, Blanca I., Willert, Cecilie W., Nørremølle, Anne, Waagepetersen, Helle S., Nielsen, Michael L.

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Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases von Southwell, Amber L, Skotte, Niels H, Bennett, C. Frank, Hayden, Michael R

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Deficient brain GABA metabolism leads to widespread impairments of astrocyte and oligodendrocyte function von Andersen, Jens V., Marian, Oana C., Qvist, Filippa L., Westi, Emil W., Aldana, Blanca I., Schousboe, Arne, Don, Anthony S., Skotte, Niels H., Wellendorph, Petrine

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Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington’s disease von Andersen, Jens V., Skotte, Niels H., Aldana, Blanca I., Nørremølle, Anne, Waagepetersen, Helle S.

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Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS von Østergaard, Michael E, Southwell, Amber L, Kordasiewicz, Holly, Watt, Andrew T, Skotte, Niels H, Doty, Crystal N, Vaid, Kuljeet, Villanueva, Erika B, Swayze, Eric E, Bennett, C Frank, Hayden, Michael R, Seth, Punit P

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Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry von Kay, Chris, Collins, Jennifer A, Skotte, Niels H, Southwell, Amber L, Warby, Simon C, Caron, Nicholas S, Doty, Crystal N, Nguyen, Betty, Griguoli, Annamaria, Ross, Colin J, Squitieri, Ferdinando, Hayden, Michael R

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Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome von Utami, Kagistia Hana, Skotte, Niels H., Colaço, Ana R., Yusof, Nur Amirah Binte Mohammad, Sim, Bernice, Yeo, Xin Yi, Bae, Han-Gyu, Garcia-Miralles, Marta, Radulescu, Carola I., Chen, Qiyu, Chaldaiopoulou, Georgia, Liany, Herty, Nama, Srikanth, Peteri, Ulla-Kaisa A., Sampath, Prabha, Castrén, Maija L., Jung, Sangyong, Mann, Matthias, Pouladi, Mahmoud A.

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Palmitoylation of caspase-6 by HIP14 regulates its activation von Skotte, Niels H, Sanders, Shaun S, Singaraja, Roshni R, Ehrnhoefer, Dagmar E, Vaid, Kuljeet, Qiu, Xiaofan, Kannan, Srinivasaragavan, Verma, Chandra, Hayden, Michael R

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