Chronic myeloid leukemia: mechanisms of blastic transformation von Perrotti, Danilo, Jamieson, Catriona, Goldman, John, Skorski, Tomasz

Volltext

Molecular basis of microhomology-mediated end-joining by purified full-length Polθ von Black, Samuel J., Ozdemir, Ahmet Y., Kashkina, Ekaterina, Kent, Tatiana, Rusanov, Timur, Ristic, Dejan, Shin, Yeonoh, Suma, Antonio, Hoang, Trung, Chandramouly, Gurushankar, Siddique, Labiba A., Borisonnik, Nikita, Sullivan-Reed, Katherine, Mallon, Joseph S., Skorski, Tomasz, Carnevale, Vincenzo, Murakami, Katsuhiko S., Wyman, Claire, Pomerantz, Richard T.

Volltext

Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours von Barszczewska-Pietraszek, Gabriela, Drzewiecka, Małgorzata, Czarny, Piotr, Skorski, Tomasz, Śliwiński, Tomasz

Volltext

BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability von Skorski, Tomasz

Volltext

Polθ Inhibitor (ART558) Demonstrates a Synthetic Lethal Effect with PARP and RAD52 Inhibitors in Glioblastoma Cells von Barszczewska-Pietraszek, Gabriela, Czarny, Piotr, Drzewiecka, Małgorzata, Błaszczyk, Maciej, Radek, Maciej, Synowiec, Ewelina, Wigner-Jeziorska, Paulina, Sitarek, Przemysław, Szemraj, Janusz, Skorski, Tomasz, Śliwiński, Tomasz

Volltext

Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile von Cramer-Morales, Kimberly, Nieborowska-Skorska, Margaret, Scheibner, Kara, Padget, Michelle, Irvine, David A., Sliwinski, Tomasz, Haas, Kimberly, Lee, Jaewoong, Geng, Huimin, Roy, Darshan, Slupianek, Artur, Rassool, Feyruz V., Wasik, Mariusz A., Childers, Wayne, Copland, Mhairi, Müschen, Markus, Civin, Curt I., Skorski, Tomasz

Volltext

PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks von Vekariya, Umeshkumar, Minakhin, Leonid, Chandramouly, Gurushankar, Tyagi, Mrityunjay, Kent, Tatiana, Sullivan-Reed, Katherine, Atkins, Jessica, Ralph, Douglas, Nieborowska-Skorska, Margaret, Kukuyan, Anna-Mariya, Tang, Hsin-Yao, Pomerantz, Richard T., Skorski, Tomasz

Volltext

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms von Nieborowska-Skorska, Margaret, Maifrede, Silvia, Dasgupta, Yashodhara, Sullivan, Katherine, Flis, Sylwia, Le, Bac Viet, Solecka, Martyna, Belyaeva, Elizaveta A., Kubovcakova, Lucia, Nawrocki, Morgan, Kirschner, Martin, Zhao, Huaqing, Prchal, Josef T., Piwocka, Katarzyna, Moliterno, Alison R., Wasik, Mariusz, Koschmieder, Steffen, Green, Tony R., Skoda, Radek C., Skorski, Tomasz

Volltext

BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance von Koptyra, Mateusz, Falinski, Rafal, Nowicki, Michal O., Stoklosa, Tomasz, Majsterek, Ireneusz, Nieborowska-Skorska, Margaret, Blasiak, Janusz, Skorski, Tomasz

Volltext

Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM von Ito, Fumiaki, Li, Ziyuan, Minakhin, Leonid, Chandramouly, Gurushankar, Tyagi, Mrityunjay, Betsch, Robert, Krais, John J., Taberi, Bernadette, Vekariya, Umeshkumar, Calbert, Marissa, Skorski, Tomasz, Johnson, Neil, Chen, Xiaojiang S., Pomerantz, Richard T.

Volltext

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells von Bolton-Gillespie, Elisabeth, Schemionek, Mirle, Klein, Hans-Ulrich, Flis, Sylwia, Hoser, Grazyna, Lange, Thoralf, Nieborowska-Skorska, Margaret, Maier, Jacqueline, Kerstiens, Linda, Koptyra, Mateusz, Müller, Martin C., Modi, Hardik, Stoklosa, Tomasz, Seferynska, Ilona, Bhatia, Ravi, Holyoake, Tessa L., Koschmieder, Steffen, Skorski, Tomasz

Volltext

Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia von Di Marcantonio, Daniela, Martinez, Esteban, Sidoli, Simone, Vadaketh, Jessica, Nieborowska-Skorska, Margaret, Gupta, Anushk, Meadows, Jake M, Ferraro, Francesca, Masselli, Elena, Challen, Grant A, Milsom, Michael D, Scholl, Claudia, Fröhling, Stefan, Balachandran, Siddharth, Skorski, Tomasz, Garcia, Benjamin A, Mirandola, Prisco, Gobbi, Giuliana, Garzon, Ramiro, Vitale, Marco, Sykes, Stephen M

Volltext

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells von Sullivan-Reed, Katherine, Bolton-Gillespie, Elisabeth, Dasgupta, Yashodhara, Langer, Samantha, Siciliano, Micheal, Nieborowska-Skorska, Margaret, Hanamshet, Kritika, Belyaeva, Elizaveta A., Bernhardy, Andrea J., Lee, Jaewong, Moore, Morgan, Zhao, Huaqing, Valent, Peter, Matlawska-Wasowska, Ksenia, Müschen, Markus, Bhatia, Smita, Bhatia, Ravi, Johnson, Neil, Wasik, Mariusz A., Mazin, Alexander V., Skorski, Tomasz

Volltext

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection von Sullivan, Katherine, Cramer-Morales, Kimberly, McElroy, Daniel L, Ostrov, David A, Haas, Kimberly, Childers, Wayne, Hromas, Robert, Skorski, Tomasz

Volltext

Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors von Fried, William, Tyagi, Mrityunjay, Minakhin, Leonid, Chandramouly, Gurushankar, Tredinnick, Taylor, Ramanjulu, Mercy, Auerbacher, William, Calbert, Marissa, Rusanov, Timur, Hoang, Trung, Borisonnik, Nikita, Betsch, Robert, Krais, John J., Wang, Yifan, Vekariya, Umeshkumar M., Gordon, John, Morton, George, Kent, Tatiana, Skorski, Tomasz, Johnson, Neil, Childers, Wayne, Chen, Xiaojiang S., Pomerantz, Richard T.

Volltext

Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors von Nieborowska-Skorska, Margaret, Kopinski, Piotr K., Ray, Regina, Hoser, Grazyna, Ngaba, Danielle, Flis, Sylwia, Cramer, Kimberly, Reddy, Mamatha M., Koptyra, Mateusz, Penserga, Tyrone, Glodkowska-Mrowka, Eliza, Bolton, Elisabeth, Holyoake, Tessa L., Eaves, Connie J., Cerny-Reiterer, Sabine, Valent, Peter, Hochhaus, Andreas, Hughes, Timothy P., van der Kuip, Heiko, Sattler, Martin, Wiktor-Jedrzejczak, Wieslaw, Richardson, Christine, Dorrance, Adrienne, Stoklosa, Tomasz, Williams, David A., Skorski, Tomasz

Volltext

Relationship between Oxidative Stress and Imatinib Resistance in Model Chronic Myeloid Leukemia Cells von Głowacki, Sylwester, Synowiec, Ewelina, Szwed, Marzena, Toma, Monika, Skorski, Tomasz, Śliwiński, Tomasz

Volltext

Polθ promotes the repair of 5′-DNA-protein crosslinks by microhomology-mediated end-joining von Chandramouly, Gurushankar, Liao, Shuren, Rusanov, Timur, Borisonnik, Nikita, Calbert, Marissa L., Kent, Tatiana, Sullivan-Reed, Katherine, Vekariya, Umeshkumar, Kashkina, Ekaterina, Skorski, Tomasz, Yan, Hong, Pomerantz, Richard T.

Volltext

Publisher Correction: Molecular basis of microhomology-mediated end-joining by purified full-length Polθ von Black, Samuel J., Ozdemir, Ahmet Y., Kashkina, Ekaterina, Kent, Tatiana, Rusanov, Timur, Ristic, Dejan, Shin, Yeonoh, Suma, Antonio, Hoang, Trung, Chandramouly, Gurushankar, Siddique, Labiba A., Borisonnik, Nikita, Sullivan-Reed, Katherine, Mallon, Joseph S., Skorski, Tomasz, Carnevale, Vincenzo, Murakami, Katsuhiko S., Wyman, Claire, Pomerantz, Richard T.

Volltext

DNA damage response genes as biomarkers of therapeutic outcomes in acute myeloid leukemia patients von Karami, Adam, Skorski, Tomasz

Volltext