The different autophagy degradation pathways and neurodegeneration von Fleming, Angeleen, Bourdenx, Mathieu, Fujimaki, Motoki, Karabiyik, Cansu, Krause, Gregory J., Lopez, Ana, Martín-Segura, Adrián, Puri, Claudia, Scrivo, Aurora, Skidmore, John, Son, Sung Min, Stamatakou, Eleanna, Wrobel, Lidia, Zhu, Ye, Cuervo, Ana Maria, Rubinsztein, David C.

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A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death von Scott, Duncan E., Francis-Newton, Nicola J., Marsh, May E., Coyne, Anthony G., Fischer, Gerhard, Moschetti, Tommaso, Bayly, Andrew R., Sharpe, Timothy D., Haas, Kalina T., Barber, Lorraine, Valenzano, Chiara R., Srinivasan, Rajavel, Huggins, David J., Lee, Miyoung, Emery, Amy, Hardwick, Bryn, Ehebauer, Matthias, Dagostin, Claudio, Esposito, Alessandro, Pellegrini, Luca, Perrior, Trevor, McKenzie, Grahame, Blundell, Tom L., Hyvönen, Marko, Skidmore, John, Venkitaraman, Ashok R., Abell, Chris

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Systematic Investigation of the Permeability of Androgen Receptor PROTACs von Scott, Duncan E, Rooney, Timothy P. C, Bayle, Elliott D, Mirza, Tashfina, Willems, Henriette M. G, Clarke, Jonathan H, Andrews, Stephen P, Skidmore, John

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Asymmetric epoxidation of electron-deficient olefins von Porter, Michael J., Skidmore, John

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The Asymmetric Aza-silyl-Prins Reaction: Synthesis of Enantiopure Piperidines von Mittapalli, Ramana R, Guesné, Sebastien J. J, Parker, Robert J, Klooster, Wim T, Coles, Simon J, Skidmore, John, Dobbs, Adrian P

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Disease phenotypic screening in neuron-glia cocultures identifies blockers of inflammatory neurodegeneration von Birkle, Timothy J.Y., Willems, Henriette M.G., Skidmore, John, Brown, Guy C.

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Small molecules, big targets: drug discovery faces the protein–protein interaction challenge von Scott, Duncan E., Bayly, Andrew R., Abell, Chris, Skidmore, John

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Optimization of Sphingosine-1-phosphate‑1 Receptor Agonists: Effects of Acidic, Basic, and Zwitterionic Chemotypes on Pharmacokinetic and Pharmacodynamic Profiles von Skidmore, John, Heer, Jag, Johnson, Christopher N, Norton, David, Redshaw, Sally, Sweeting, Jennifer, Hurst, David, Cridland, Andrew, Vesey, David, Wall, Ian, Ahmed, Mahmood, Rivers, Dean, Myatt, James, Giblin, Gerard, Philpott, Karen, Kumar, Umesh, Stevens, Alexander, Bit, Rino A, Haynes, Andrea, Taylor, Simon, Watson, Robert, Witherington, Jason, Demont, Emmanuel, Heightman, Tom D

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Therapeutic inhibition of ferroptosis in neurodegenerative disease von Ryan, Sean K., Ugalde, Cathryn L., Rolland, Anne-Sophie, Skidmore, John, Devos, David, Hammond, Timothy R.

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Inhibiting Ca2+ channels in Alzheimer’s disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia von Korte, Nils, Barkaway, Anna, Wells, Jack, Freitas, Felipe, Sethi, Huma, Andrews, Stephen P., Skidmore, John, Stevens, Beth, Attwell, David

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The toolbox is open, but who should pay for the job? Establishing industry-funded grant programmes for early-stage drug research could help address the dual challenges of declining... von Ladbury, John E, Hall, Adrian, Skidmore, John

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Development of Selective Phosphatidylinositol 5‑Phosphate 4‑Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode von Boffey, Helen K., Rooney, Timothy P. C., Willems, Henriette M. G., Edwards, Simon, Green, Christopher, Howard, Tina, Ogg, Derek, Romero, Tamara, Scott, Duncan E., Winpenny, David, Duce, James, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.

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Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents von Stockwell, Simon R, Scott, Duncan E, Fischer, Gerhard, Guarino, Estrella, Rooney, Timothy P C, Feng, Tzu-Shean, Moschetti, Tommaso, Srinivasan, Rajavel, Alza, Esther, Asteian, Alice, Dagostin, Claudio, Alcaide, Anna, Rocaboy, Mathieu, Blaszczyk, Beata, Higueruelo, Alicia, Wang, Xuelu, Rossmann, Maxim, Perrior, Trevor R, Blundell, Tom L, Spring, David R, McKenzie, Grahame, Abell, Chris, Skidmore, John, Venkitaraman, Ashok R, Hyvönen, Marko

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p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003 von Taylor, Lewis W., Simzer, Elizabeth M., Pimblett, Claire, Lacey-Solymar, Oscar T. T., McGeachan, Robert I., Meftah, Soraya, Rose, Jamie L., Spires-Jones, Maxwell P., Holt, Kristján, Catterson, James H., Koch, Henner, Liaquat, Imran, Clarke, Jonathan H., Skidmore, John, Smith, Colin, Booker, Sam A., Brennan, Paul M., Spires-Jones, Tara L., Durrant, Claire S.

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The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules von Rooney, Timothy P. C., Aldred, Gregory G., Boffey, Helen K., Willems, Henriëtte M. G., Edwards, Simon, Chawner, Stephen J., Scott, Duncan E., Green, Christopher, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.

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Inhibiting Ca 2+ channels in Alzheimer's disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia von Korte, Nils, Barkaway, Anna, Wells, Jack, Freitas, Felipe, Sethi, Huma, Andrews, Stephen P, Skidmore, John, Stevens, Beth, Attwell, David

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Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities von Menzies, Fiona M., Fleming, Angeleen, Caricasole, Andrea, Bento, Carla F., Andrews, Stephen P., Ashkenazi, Avraham, Füllgrabe, Jens, Jackson, Anne, Jimenez Sanchez, Maria, Karabiyik, Cansu, Licitra, Floriana, Lopez Ramirez, Ana, Pavel, Mariana, Puri, Claudia, Renna, Maurizio, Ricketts, Thomas, Schlotawa, Lars, Vicinanza, Mariella, Won, Hyeran, Zhu, Ye, Skidmore, John, Rubinsztein, David C.

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The toolbox is open, but who should pay for the job? von Ladbury, John E., Hall, Adrian, Skidmore, John

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Development of the Juliá−Colonna Asymmetric Epoxidation Reaction:  Part 1. Preparation and Activation of the Polyleucine Catalyst von Baars, Sylvia, Drauz, Karl-Heinz, Krimmer, Hans-Peter, Roberts, Stanley M., Sander, Jörg, Skidmore, John, Zanardi, Giampaolo

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Total synthesis of (-)-nakadomarin A von Kyle, Andrew F, Jakubec, Pavol, Cockfield, Dane M, Cleator, Ed, Skidmore, John, Dixon, Darren J

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