Results of a phase 2 trial of an oral CXCR4 antagonist, mavorixafor, for treatment of WHIM syndrome von Dale, David C., Firkin, Frank, Bolyard, Audrey Anna, Kelley, Merideth, Makaryan, Vahagn, Gorelick, Kenneth J., Ebrahim, Tarek, Garg, Varun, Tang, Weihua, Jiang, Honghua, Skerlj, Renato, Beaussant Cohen, Sarah

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A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator von Heijer, Jonas M., Kruithof, Annelieke C., Amerongen, Guido, Kam, Marieke L., Thijssen, Eva, Grievink, Hendrika W., Moerland, Matthijs, Walker, Mike, Been, Kees, Skerlj, Renato, Justman, Craig, Dudgeon, Lindsay, Lansbury, Peter, Cullen, Valerie C., Hilt, Dana C., Groeneveld, Geert Jan

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Molecular Mechanism of Action of Monocyclam Versus Bicyclam Non-peptide Antagonists in the CXCR4 Chemokine Receptor von Rosenkilde, Mette M., Gerlach, Lars-Ole, Hatse, Sigrid, Skerlj, Renato T., Schols, Dominique, Bridger, Gary J., Schwartz, Thue W.

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Discovery of Novel Small Molecule Orally Bioavailable C−X−C Chemokine Receptor 4 Antagonists That Are Potent Inhibitors of T-Tropic (X4) HIV-1 Replication von Skerlj, Renato T, Bridger, Gary J, Kaller, Al, McEachern, Ernest J, Crawford, Jason B, Zhou, Yuanxi, Atsma, Bem, Langille, Jonathon, Nan, Susan, Veale, Duane, Wilson, Trevor, Harwig, Curtis, Hatse, Sigrid, Princen, Katrien, De Clercq, Erik, Schols, Dominique

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Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein–Protein Interaction Site von de Araujo, Aline Dantas, Lim, Junxian, Good, Andrew C, Skerlj, Renato T, Fairlie, David P

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AMD3100, a CxCR4 Antagonist, Attenuates Allergic Lung Inflammation and Airway Hyperreactivity von Lukacs, Nicholas W., Berlin, Aaron, Schols, Dominique, Skerlj, Renato T., Bridger, Gary J.

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Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor von Rosenkilde, Mette M, Gerlach, Lars-Ole, Jakobsen, Janus S, Skerlj, Renato T, Bridger, Gary J, Schwartz, Thue W

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The molecular pharmacology of AMD11070: An orally bioavailable CXCR4 HIV entry inhibitor von Mosi, Renee M., Anastassova, Virginia, Cox, Jennifer, Darkes, Marilyn C., Idzan, Stefan R., Labrecque, Jean, Lau, Gloria, Nelson, Kim L., Patel, Ketan, Santucci, Zefferino, Wong, Rebecca S.Y., Skerlj, Renato T., Bridger, Gary J., Huskens, Dana, Schols, Dominique, Fricker, Simon P.

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Metal compounds for the treatment of parasitic diseases von Fricker, Simon P., Mosi, Renee M., Cameron, Beth R., Baird, Ian, Zhu, Youngbao, Anastassov, Virginia, Cox, Jennifer, Doyle, Patricia S., Hansell, Elizabeth, Lau, Gloria, Langille, Jonathan, Olsen, Micki, Qin, Ling, Skerlj, Renato, Wong, Rebecca S.Y., Santucci, Zefferino, McKerrow, James H.

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Inhibition of the cathepsin cysteine proteases B and K by square-planar cycloaurated gold(III) compounds and investigation of their anti-cancer activity von Zhu, Yongbao, Cameron, Beth R., Mosi, Renee, Anastassov, Virginia, Cox, Jennifer, Qin, Ling, Santucci, Zefferino, Metz, Markus, Skerlj, Renato T., Fricker, Simon P.

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AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor von Hatse, Sigrid, Princen, Katrien, Clercq, Erik De, Rosenkilde, Mette M., Schwartz, Thue W., Hernandez-Abad, Pedro E., Skerlj, Renato T., Bridger, Gary J., Schols, Dominique

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Synthesis and Structure−Activity Relationships of Azamacrocyclic C-X-C Chemokine Receptor 4 Antagonists: Analogues Containing a Single Azamacrocyclic Ring are Potent Inhibitors of... von Bridger, Gary J, Skerlj, Renato T, Hernandez-Abad, Pedro E, Bogucki, David E, Wang, Zhongren, Zhou, Yuanxi, Nan, Susan, Boehringer, Eva M, Wilson, Trevor, Crawford, Jason, Metz, Markus, Hatse, Sigrid, Princen, Katrien, De Clercq, Erik, Schols, Dominique

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Implications of Promiscuous Pim-1 Kinase Fragment Inhibitor Hydrophobic Interactions for Fragment-Based Drug Design von Good, Andrew C, Liu, Jinyu, Hirth, Bradford, Asmussen, Gary, Xiang, Yibin, Biemann, Hans-Peter, Bishop, Kimberly A, Fremgen, Trisha, Fitzgerald, Maria, Gladysheva, Tatiana, Jain, Annuradha, Jancsics, Katherine, Metz, Markus, Papoulis, Andrew, Skerlj, Renato, Stepp, J. David, Wei, Ronnie R

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Spontaneous Enzymatically Mediated Dynamic Kinetic Resolution of 8-Amino-5,6,7,8-tetrahydroquinoline von Crawford, Jason B, Skerlj, Renato T, Bridger, Gary J

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HIV - 1 entry inhibition by small - molecule CCR5 antagonists: A combined molecular modeling and mutant study using a high - throughput assay von Labrecque, Jean, Metz, Markus, Lau, Gloria, Darkes, Marilyn C, Wong, Rebecca S.Y, Bogucki, David, Carpenter, Bryon, Chen, Gang, Li, Tongshuang, Nan, Susan, Schols, Dominique, Bridger, Gary J, Fricker, Simon P, Skerlj, Renato T

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Rhenium Inhibitors of Cathepsin B (ReO(SYS)X (Where Y = S, py; X = Cl, Br, SPhOMe-p)):  Synthesis and Mechanism of Inhibition von Mosi, Renee, Baird, Ian R, Cox, Jennifer, Anastassov, Virginia, Cameron, Beth, Skerlj, Renato T, Fricker, Simon P

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Prospective CCR5 Small Molecule Antagonist Compound Design Using a Combined Mutagenesis/Modeling Approach von Metz, Markus, Bourque, Elyse, Labrecque, Jean, Danthi, Sanjay J, Langille, Jonathan, Harwig, Curtis, Yang, Wen, Darkes, Marilyn C, Lau, Gloria, Santucci, Zefferino, Bridger, Gary J, Schols, Dominique, Fricker, Simon P, Skerlj, Renato T

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Molecular Interactions of Cyclam and Bicyclam Non-peptide Antagonists with the CXCR4 Chemokine Receptor von Gerlach, L O, Skerlj, R T, Bridger, G J, Schwartz, T W

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Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist von PRINCEN, Katrien, HATSE, Sigrid, SCHOLS, Dominique, VERMEIRE, Kurt, AQUARO, Stefano, DE CLERCQ, Erik, GERLACH, Lars-Ole, ROSENKILDE, Mette, SCHWARTZ, Thue W, SKERLJ, Renato, BRIDGER, Gary

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Practical Convergent Laboratory-Scale Synthesis of a CCR5 Receptor Antagonist von Crawford, Jason B, Chen, Gang, Carpenter, Bryon, Wilson, Trevor, Ji, Jenny, Skerlj, Renato T, Bridger, Gary J

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