Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism von Killion, Elizabeth A., Chen, Michelle, Falsey, James R., Sivits, Glenn, Hager, Todd, Atangan, Larissa, Helmering, Joan, Lee, Jae, Li, Hongyan, Wu, Bin, Cheng, Yuan, Véniant, Murielle M., Lloyd, David J.

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Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue von Véniant, Murielle M., Sivits, Glenn, Helmering, Joan, Komorowski, Renee, Lee, Jae, Fan, Wei, Moyer, Carolyn, Lloyd, David J.

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Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice von Xu, Jing, Lloyd, David J, Hale, Clarence, Stanislaus, Shanaka, Chen, Michelle, Sivits, Glenn, Vonderfecht, Steven, Hecht, Randy, Li, Yue-Sheng, Lindberg, Richard A, Chen, Jin-Long, Jung, Dae Young, Zhang, Zhiyou, Ko, Hwi-Jin, Kim, Jason K, Véniant, Murielle M

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors von Lloyd, David J., St Jean, David J., Kurzeja, Robert J. M., Wahl, Robert C., Michelsen, Klaus, Cupples, Rod, Chen, Michelle, Wu, John, Sivits, Glenn, Helmering, Joan, Komorowski, Renée, Ashton, Kate S., Pennington, Lewis D., Fotsch, Christopher, Vazir, Mukta, Chen, Kui, Chmait, Samer, Zhang, Jiandong, Liu, Longbin, Norman, Mark H., Andrews, Kristin L., Bartberger, Michael D., Van, Gwyneth, Galbreath, Elizabeth J., Vonderfecht, Steven L., Wang, Minghan, Jordan, Steven R., Véniant, Murielle M., Hale, Clarence

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Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor von Gu, Wei, Winters, Katherine A, Motani, Alykhan S, Komorowski, Renée, Zhang, Ying, Liu, Qingxiang, Wu, Xiaosu, Rulifson, Ingrid C, Sivits, Jr, Glenn, Graham, Melissa, Yan, Hai, Wang, Paul, Moore, Steve, Meng, Tina, Lindberg, Richard A, Véniant, Murielle M

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept von Ashton, Kate S., Andrews, Kristin L., Bryan, Marion C., Chen, Jie, Chen, Kui, Chen, Michelle, Chmait, Samer, Croghan, Michael, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steve R., Kurzeja, Robert J. M., Michelsen, Klaus, Pennington, Lewis D., Poon, Steve F., Sivits, Glenn, Van, Gwyneth, Vonderfecht, Steve L., Wahl, Robert C., Zhang, Jiandong, Lloyd, David J., Hale, Clarence, St. Jean, David J.

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Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice von Gu, Wei, Lloyd, David J, Chinookswong, Narumol, Komorowski, Renée, Sivits, Jr, Glenn, Graham, Melissa, Winters, Katherine A, Yan, Hai, Boros, Laszlo G, Lindberg, Richard A, Véniant, Murielle M

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the N‑Arylsulfonamid... von Nishimura, Nobuko, Norman, Mark H, Liu, Longbin, Yang, Kevin C, Ashton, Kate S, Bartberger, Michael D, Chmait, Samer, Chen, Jie, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steven R, Kunz, Roxanne K, Pennington, Lewis D, Poon, Steve F, Siegmund, Aaron, Sivits, Glenn, Lloyd, David J, Hale, Clarence, St. Jean, David J

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Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperg... von Gu, Wei, Yan, Hai, Winters, Katherine A, Komorowski, Renée, Vonderfecht, Steven, Atangan, Larissa, Sivits, Glenn, Hill, David, Yang, Jie, Bi, Vivian, Shen, Yuqing, Hu, Sylvia, Boone, Tom, Lindberg, Richard A, Véniant, Murielle M

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Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ... von Pennington, Lewis D, Bartberger, Michael D, Croghan, Michael D, Andrews, Kristin L, Ashton, Kate S, Bourbeau, Matthew P, Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Hong, Fang-Tsao, Hungate, Randall W, Jordan, Steven R, Kong, Ke, Liu, Longbin, Michelsen, Klaus, Moyer, Carolyn, Nishimura, Nobuko, Norman, Mark H, Reichelt, Andreas, Siegmund, Aaron C, Sivits, Glenn, Tadesse, Seifu, Tegley, Christopher M, Van, Gwyneth, Yang, Kevin C, Yao, Guomin, Zhang, Jiandong, Lloyd, David J, Hale, Clarence, St. Jean, David J

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis von Tamayo, Nuria A, Norman, Mark H, Bartberger, Michael D, Hong, Fang-Tsao, Bo, Yunxin, Liu, Longbin, Nishimura, Nobuko, Yang, Kevin C, Tadesse, Seifu, Fotsch, Christopher, Chen, Jie, Chmait, Samer, Cupples, Rod, Hale, Clarence, Jordan, Steven R, Lloyd, David J, Sivits, Glenn, Van, Gwyneth, St. Jean, David J

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinet... von St. Jean, David J., Ashton, Kate S., Bartberger, Michael D., Chen, Jie, Chmait, Samer, Cupples, Rod, Galbreath, Elizabeth, Helmering, Joan, Hong, Fang-Tsao, Jordan, Steven R., Liu, Longbin, Kunz, Roxanne K., Michelsen, Klaus, Nishimura, Nobuko, Pennington, Lewis D., Poon, Steve F., Reid, Darren, Sivits, Glenn, Stec, Markian M., Tadesse, Seifu, Tamayo, Nuria, Van, Gwyneth, Yang, Kevin C., Zhang, Jiandong, Norman, Mark H., Fotsch, Christopher, Lloyd, David J., Hale, Clarence

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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 4. Exploration of a Novel Binding Pocket von Hong, Fang-Tsao, Norman, Mark H, Ashton, Kate S, Bartberger, Michael D, Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Jordan, Steven R, Lloyd, David J, Sivits, Glenn, Tadesse, Seifu, Hale, Clarence, St. Jean, David J

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Correction to Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept von Ashton, Kate S, Andrews, Kristin L, Bryan, Marian C, Chen, Jie, Chen, Kui, Chen, Michelle, Chmait, Samer, Croghan, Michael, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steve R, Kurzeja, Robert J. M, Michelsen, Klaus, Pennington, Lewis D, Poon, Steve F, Sivits, Glenn, Van, Gwyneth, Vonderfecht, Steve L, Wahl, Robert C, Zhang, Jiandong, Lloyd, David J, Hale, Clarence, St. Jean, David J

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Long-Term Inhibition of the Glucagon Receptor with a Monoclonal Antibody in Mice Causes Sustained Improvement in Glycemic Control, with Reversible α-Cell Hyperplasia and Hypergluc... von Wei Gu, Hai Yan, Katherine A. Winters, Renée Komorowski, Steven Vonderfecht, Larissa Atangan, Glenn Sivits, David Hill, Jie Yang, Vivian Bi, Yuqing Shen, Sylvia Hu, Tom Boone, Richard A. Lindberg, Murielle M. Véniant

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Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor von WEI GU, WINTERS, Katherine A, HAI YAN, WANG, Paul, MOORE, Steve, TINA MENG, LINDBERG, Richard A, VENIANT, Murielle M, MOTANI, Alykhan S, KOMOROWSKI, Renée, YING ZHANG, QINGXIANG LIU, XIAOSU WU, RULIFSON, Ingrid C, SIVITS, Glenn, GRAHAM, Melissa

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METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING BINDING PROTEINS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR) IN COMBINATION WITH GLP-1 AGONISTS von MIN, XIAOSHAN, LLOYD, DAVID J, SIVITS, GLENN N, MURAWSKY, CHRISTOPHER, BATES, DARREN L, HO, SHU-YIN, KOMOROWSKI, RENNE, CLAVETTE, BRANDON C. P, AGRAWAL, NEERAJ, VENIANT-ELLISON, MURIELLE M, YIE, JUNMING, WANG, JINGHONG, FLOTZ, IAN N, WANG, ZHULUN, SHI, DONGHUI

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METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING BINDING PROTEINS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR) IN COMBINATION WITH GLP-1 AGONISTS von MIN, XIAOSHAN, LLOYD, DAVID J, SIVITS, GLENN N, KOMOROWSKI, RENEE, MURAWSKY, CHRISTOPHER, BATES, DARREN L, HO, SHU-YIN, CLAVETTE, BRANDON C. P, AGRAWAL, NEERAJ, VENIANT-ELLISON, MURIELLE M, FOLTZ, IAN N, YIE, JUNMING, WANG, JINGHONG, WANG, ZHULUN, SHI, DONGHUI

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Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists von Bates, Darren L, Shi, Donghui, Yie, Junming, Veniant-Ellison, Murielle M, Agrawal, Neeraj, Foltz, Ian N, Min, Xiaoshan, Komorowski, Renee, Clavette, Brandon C. P, Wang, Zhulun, Wang, Jinghong, Ho, Shu-yin, Murawsky, Christopher, Sivits, Jr., Glenn N, Lloyd, David J

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METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING BINDING PROTEINS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR) IN COMBINATION WITH GLP-1 AGONISTS von WANG, Zhulun, BATES, Darren L, SIVITS Jr., Glenn N, MURAWSKY, Christopher, YIE, Junming, VENIANT-ELLISON, Murielle M, SHI, Donghui, MIN, Xiaoshan, KOMOROWSKI, Renee, CLAVETTE, Brandon C. P, HO, Shu-yin, WANG, Jinghong, AGRAWAL, Neeraj, FOLTZ, Ian N, LLOYD, David J

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