Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation von Wong, Birming, Lumma, William C., Smith, Anthony M., Sisko, John T., Wright, Samuel D., Cai, Tian‐Quan

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Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: Aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif von Su, Dai-Shi, Lim, John J., Tinney, Elizabeth, Tucker, Thomas J., Saggar, Sandeep, Sisko, John T., Wan, Bang-Lin, Young, Mary Beth, Anderson, Kenneth D., Rudd, Deanne, Munshi, Vandna, Bahnck, Carolyn, Felock, Peter J., Lu, Meiquing, Lai, Ming-Tain, Touch, Sinoeun, Moyer, Gregory, DiStefano, Daniel J., Flynn, Jessica A., Liang, Yuexia, Sanchez, Rosa, Perlow-Poehnelt, Rebecca, Miller, Mike, Vacca, Joe P., Williams, Theresa M., Anthony, Neville J.

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Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Tra... von Tucker, Thomas J, Sisko, John T, Tynebor, Robert M, Williams, Theresa M, Felock, Peter J, Flynn, Jessica A, Lai, Ming-Tain, Liang, Yuexia, McGaughey, Georgia, Liu, Meiquing, Miller, Mike, Moyer, Gregory, Munshi, Vandna, Perlow-Poehnelt, Rebecca, Prasad, Sridhar, Reid, John C, Sanchez, Rosa, Torrent, Maricel, Vacca, Joseph P, Wan, Bang-Lin, Yan, Youwei

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The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations von Tucker, Thomas J., Saggar, Sandeep, Sisko, John T., Tynebor, Robert M., Williams, Theresa M., Felock, Peter J., Flynn, Jessica A., Lai, Ming-Tain, Liang, Yuexia, McGaughey, Georgia, Liu, Meiquing, Miller, Mike, Moyer, Gregory, Munshi, Vandna, Perlow-Poehnelt, Rebecca, Prasad, Sridhar, Sanchez, Rosa, Torrent, Maricel, Vacca, Joseph P., Wan, Bang-Lin, Yan, Youwei

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The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases von Tucker, Thomas J, Abrams, Marc T, Buser, Carolyn A, Davide, Joseph P, Ellis-Hutchings, Michelle, Fernandes, Christine, Gibbs, Jackson B, Graham, Samuel L, Hartman, George D, Huber, Hans E, Liu, Dongming, Lobell, Robert B, Lumma, William C, Robinson, Ronald G, Sisko, John T, Smith, Anthony M

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Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase von Sisko, John T., Tucker, Thomas J., Bilodeau, Mark T., Buser, Carolyn A., Ciecko, Patrice A., Coll, Kathleen E., Fernandes, Christine, Gibbs, Jackson B., Koester, Timothy J., Kohl, Nancy, Lynch, Joseph J., Mao, Xianzhi, McLoughlin, Debra, Miller-Stein, Cynthia M., Rodman, Leonard D., Rickert, Keith W., Sepp-Lorenzino, Laura, Shipman, Jennifer M., Thomas, Kenneth A., Wong, Bradley K., Hartman, George D.

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Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures:  Rapid Structure−Activity Studies by Solid-Phase Synthesis von Lumma, William C, Witherup, Keith M, Tucker, Thomas J, Brady, Steven F, Sisko, John T, Naylor-Olsen, Adel M, Lewis, S. Dale, Lucas, Bobby J, Vacca, Joseph P

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2-Arylindole-3-acetamides: FPP-Competitive inhibitors of farnesyl protein transferase von Trotter, B.Wesley, Quigley, Amy G., Lumma, William C., Sisko, John T., Walsh, Eileen S., Hamann, Christian S., Robinson, Ronald G., Bhimnathwala, Hema, Kolodin, D.Garrett, Zheng, Wei, Buser, Carolyn A., Huber, Hans E., Lobell, Robert B., Kohl, Nancy E., Williams, Theresa M., Graham, Samuel L., Dinsmore, Christopher J.

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Polyphosphazenes with etheric side groups: prospective biomedical and solid electrolyte polymers von Allcock, Harry R, Austin, Paul E, Neenan, Thomas X, Sisko, John T, Blonsky, Peter M, Shriver, Duward F

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Effects of organic side group structures on the properties of poly(organophosphazenes) von Allcock, Harry R, Connolly, Mark S, Sisko, John T, Al-Shali, Saman

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composto, composição farmacêutica, método para a profilazia ou tratamento de infecção pela hiv ou para a profilaxia, tratamento ou retardo no início da aids von Robert Tynebor, Neville Anthony, Thomas J. Tucker, Robert Gomez, Samson M. Jolly, John T. Sisko

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FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS von Wai, John, Peng, Xuanjia, Hartingh, Timothy J, Sisko, John T, Raheem, Izzat T, Hu, Lihong, Graham, Thomas, Coleman, Paul J, Schreier, John

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Characterization of the two-step pathway for inhibition of thrombin by alpha-ketoamide transition state analogs von Lewis, S D, Lucas, B J, Brady, S F, Sisko, J T, Cutrona, K J, Sanderson, P E, Freidinger, R M, Mao, S S, Gardell, S J, Shafer, J A

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Amide and α-keto carbonyl inhibitors of thrombin based on arginine and lysine: Synthesis, stability and biological characterization von Brady, Stephen F., Sisko, John T., Stauffer, Kenneth J., Colton, Christiana D., Qiu, Howard, Lewis, Sidney D., Ng, Assunta S., Shafer, Jules A., Bogusky, Michael J., Veber, Daniel F., Nutt, Ruth F.

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FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS von SISKO, John T, GRAHAM, Thomas, HU, Lihong, RAHEEM, Izzat T, PENG, Xuanjia, SCHREIER, John, WAI, John, HARTINGH, Timothy J, COLEMAN, Paul J

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2-Arylindole-3-acetamides von Trotter, B.Wesley, Quigley, Amy G., Lumma, William C., Sisko, John T., Walsh, Eileen S., Hamann, Christian S., Robinson, Ronald G., Bhimnathwala, Hema, Kolodin, D.Garrett, Zheng, Wei, Buser, Carolyn A., Huber, Hans E., Lobell, Robert B., Kohl, Nancy E., Williams, Theresa M., Graham, Samuel L., Dinsmore, Christopher J.

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FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS von SISKO, John T, GRAHAM, Thomas, HU, Lihong, RAHEEM, Izzat T, PENG, Xuanjia, SCHREIER, John, WAI, John, HARTINGH, Timothy J, COLEMAN, Paul J

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FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS von Wai, John, Peng, Xuanjia, Hartingh, Timothy J, Sisko, John T, Raheem, Izzat T, Hu, Lihong, Graham, Thomas, Coleman, Paul J, Schreier, John

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FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS von HU Lihong, HARTINGH Timothy J, WAI John, SISKO John T, RAHEEM Izzat T, GRAHAM Thomas, COLEMAN Paul J, PENG Xuanjia, SCHREIER John

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FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS von WAI, JOHN, RAHEEM, IZZAT T, GRAHAM, THOMAS, HARTINGH, TIMOTHY J, SCHREIER, JOHN, PENG, XUANJIA, HU, LIHONG, COLEMAN, PAUL J, SISKO, JOHN T

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