ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway von Kidger, Andrew M., Sipthorp, James, Cook, Simon J.

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Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis von Tomić, Goran, Sheridan, Clare, Refermat, Alice Y., Baggelaar, Marc P., Sipthorp, James, Sudarshan, Bhuvana, Ocasio, Cory A., Suárez-Bonnet, Alejandro, Priestnall, Simon L., Herbert, Eleanor, Tate, Edward W., Downward, Julian

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CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells von Roy, Sougata, Sipthorp, James, Mahata, Bidesh, Pramanik, Jhuma, Hennrich, Marco L., Gavin, Anne-Claude, Ley, Steven V., Teichmann, Sarah A.

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A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation von Ocasio, Cory A., Baggelaar, Marc P., Sipthorp, James, Losada de la Lastra, Ana, Tavares, Manuel, Volarić, Jana, Soudy, Christelle, Storck, Elisabeth M., Houghton, Jack W., Palma-Duran, Susana A., MacRae, James I., Tomić, Goran, Carr, Lotte, Downward, Julian, Eggert, Ulrike S., Tate, Edward W.

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5‑Phenyl-1,3,4-oxadiazol-2(3H)‑ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit von Mahy, William, Willis, Nicky J, Zhao, Yuguang, Woodward, Hannah L, Svensson, Fredrik, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R, Hillier, James, Kjær, Svend, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Salinas, Patricia C, Whiting, Paul, Vincent, Jean-Paul, Jones, E. Yvonne, Fish, Paul V

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A New Methodology for Incorporating Chiral Linkers into Stapled Peptides von Serrano, Juan C., Sipthorp, James, Xu, Wenshu, Itzhaki, Laura S., Ley, Steven V.

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Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit von Willis, Nicky J., Mahy, William, Sipthorp, James, Zhao, Yuguang, Woodward, Hannah L., Atkinson, Benjamin N., Bayle, Elliott D., Svensson, Fredrik, Frew, Sarah, Jeganathan, Fiona, Monaghan, Amy, Benvegnù, Stefano, Jolly, Sarah, Vecchia, Luca, Ruza, Reinis R., Kjær, Svend, Howell, Steven, Snijders, Ambrosius P., Bictash, Magda, Salinas, Patricia C., Vincent, Jean-Paul, Jones, E. Yvonne, Whiting, Paul, Fish, Paul V.

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Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivativesElectronic supplementary information (ESI) available: Experimental pr... von Atkinson, Benjamin N, Woodward, Hannah L, Sipthorp, James, Fish, Paul V

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Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors von Atkinson, Benjamin N., Steadman, David, Mahy, William, Zhao, Yuguang, Sipthorp, James, Bayle, Elliott D., Svensson, Fredrik, Papageorgiou, George, Jeganathan, Fiona, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V.

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Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivatives von Atkinson, Benjamin N, Woodward, Hannah L, Sipthorp, James, Fish, Paul V

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Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen von Atkinson, Benjamin N, Steadman, David, Zhao, Yuguang, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R, Jeganathan, Fiona, Lines, Georgie, Frew, Sarah, Monaghan, Amy, Kjær, Svend, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V

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Structural Analysis and Development of Notum Fragment Screening Hits von Zhao, Yuguang, Mahy, William, Willis, Nicky J, Woodward, Hannah L, Steadman, David, Bayle, Elliott D, Atkinson, Benjamin N, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R, Harlos, Karl, Jeganathan, Fiona, Constantinou, Stefan, Costa, Artur, Kjær, Svend, Bictash, Magda, Salinas, Patricia C, Whiting, Paul, Vincent, Jean-Paul, Fish, Paul V, Jones, E Yvonne

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Visualization of Endogenous ERK1/2 in Cells with a Bioorthogonal Covalent Probe von Sipthorp, James, Lebraud, Honorine, Gilley, Rebecca, Kidger, Andrew M, Okkenhaug, Hanneke, Saba-El-Leil, Marc, Meloche, Sylvain, Caunt, Christopher J, Cook, Simon J, Heightman, Tom D

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A palmitoyl transferase chemical genetic system to map ZDHHC-specific S-acylation von Ocasio, Cory A, Baggelaar, Marc, Sipthorp, James, Losada de la Lastra, Ana, Volarić, Jana, Soudy, Christelle, Storck, Elisabeth M, Palma-Duran, Susana A, MacRae, James I, Tomic, Goran, Carr, Lotte, Downward, Julian, S. Eggert, Ulrike, Tate, Edward W

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CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells von Roy, Sougata, Sipthorp, James, Mahata, Bidesh, Pramanik, Jhuma, Hennrich, Marco L, Gavin, Anne-Claude, Ley, Steven V, Teichmann, Sarah A

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Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis von Tomic, Goran, Refermat, Alice Y, Sheridan, Clare, Baggelaar, Marc, Sipthorp, James, Sudarshan, Bhuvana, Ocasio, Cory A, Suárez-Bonnet, Alejandro, Priestnall , Simon L, Herbert, Eleanor, Tate, Edward W, Downward, Julian

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COMPOUNDS von WILLIS, Nicky, John, MAHY, William, FISH, Paul, Vincent, WOODWARD, Hannah, ZHAO, Yuguang, VECCHIA, Luca, SIPTHORP, James, BAYLE, Elliott, D, ATKINSON, Benjamin, N, JONES, Edith, Yvonne, RUZA, Reinis, Reinholds

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Structural Analysis and Development of Notum Fragment Screening Hits von Zhao, Yuguang, Mahy, William, Willis, Nicky J, Woodward, Hannah L, Steadman, David, Bayle, Elliott D, Atkinson, Benjamin N, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R, Harlos, Karl, Jeganathan, Fiona, Constantinou, Stefan, Costa, Artur, Kjær, Svend, Bictash, Magda, Salinas, Patricia C, Whiting, Paul, Vincent, Jean-Paul, Fish, Paul V, Jones, E Yvonne

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Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit von Willis, Nicky J, Mahy, William, Sipthorp, James, Zhao, Yuguang, Woodward, Hannah L, Atkinson, Benjamin N, Bayle, Elliott D, Svensson, Fredrik, Frew, Sarah, Jeganathan, Fiona, Monaghan, Amy, Benvegnù, Stefano, Jolly, Sarah, Vecchia, Luca, Ruza, Reinis R, Kjær, Svend, Howell, Steven, Snijders, Ambrosius P, Bictash, Magda, Salinas, Patricia C, Vincent, Jean-Paul, Jones, E Yvonne, Whiting, Paul, Fish, Paul V

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ZDHHC_metabolomics_chemgen_2023.zip von Cornejo, Manuel, Tate, Edward, Ocasio, Cory, Sipthorp, James, Baggelaar, Marc Pieter, Tomic, Goran, Soudy, Christelle, Volarić, Jana, Macrae, James, Palma Duran, Susana Alejandra, Downward, Julian

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