Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells von Sini, Patrizia, James, Dominic, Chresta, Christine, Guichard, Sylvie

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The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression von Phadke, Manali S, Sini, Patrizia, Smalley, Keiran S M

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mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor von Lane, Heidi A, Wood, Jeanette M, McSheehy, Paul M J, Allegrini, Peter R, Boulay, Anne, Brueggen, Joseph, Littlewood-Evans, Amanda, Maira, Sauveur-Michel, Martiny-Baron, Georg, Schnell, Christian R, Sini, Patrizia, O'Reilly, Terence

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Wnt3a regulates proliferation and migration of HUVEC via canonical and non-canonical Wnt signaling pathways von Samarzija, Ivana, Sini, Patrizia, Schlange, Thomas, MacDonald, Gwen, Hynes, Nancy E.

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Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice von Nolt, Georgia L., Keeble, Alexander R., Wen, Yuan, Strong, Aubrey C., Thomas, Nicholas T., Valentino, Taylor R., Brightwell, Camille R., Murach, Kevin A., Patrizia, Sini, Weinstabl, Harald, Gollner, Andreas, McCarthy, John J., Fry, Christopher S., Franti, Michael, Filareto, Antonio, Peterson, Charlotte A., Dungan, Cory M.

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Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity von Cummings, Jeffrey, Hodgkinson, Cassandra, Odedra, Rajesh, Sini, Patrizia, Heaton, Simon P, Mundt, Kirsten E, Ward, Tim H, Wilkinson, Robert W, Growcott, Jim, Hughes, Andrew, Dive, Caroline

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The Antitumor and Antiangiogenic Activity of Vascular Endothelial Growth Factor Receptor Inhibition Is Potentiated by ErbB1 Blockade von SINI, Patrizia, WYDER, Lorenza, SCHNELL, Christian, O'REILLY, Terence, LITTLEWOOD, Amanda, BRANDT, Ralph, HYNES, Nancy E, WOOD, Jeanette

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AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity von CHRESTA, Christine M, DAVIES, Barry R, JAMES, Dominic, HOWARD, Zoe, DUDLEY, Phillippa, HUGHES, Gareth, SMITH, Lisa, MAGUIRE, Sharon, HUMMERSONE, Marc, MALAGU, Karine, MENEAR, Keith, JENKINS, Richard, HICKSON, Ian, JACOBSEN, Matt, SMITH, Graeme C. M, GUICHARD, Sylvie, PASS, Martin, HARDING, Tom, COSULICH, Sabina, CRITCHLOW, Susan E, VINCENT, John P, ELLSTON, Rebecca, JONES, Darren, SINI, Patrizia

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Abstract 703: A novel ATP-competitive MEK/Aurora kinase inhibitor BI-847325 reverses acquired BRAF inhibitor resistance through suppression of Mcl-1 and inhibition of MEK expressio... von Phadke, Manali S., Sini, Patrizia, Smalley, Keiran

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Heterogeneous Profile of ROR1 Protein Expression across Tumor Types von Raso, Maria Gabriela, Barrientos Toro, Elizve, Evans, Kurt, Rizvi, Yasmeen, Lazcano, Rossana, Akcakanat, Argun, Sini, Patrizia, Trapani, Francesca, Madlener, Eva Johanna, Waldmeier, Lorenz, Lazar, Alexander, Meric-Bernstam, Funda

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Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases von Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K, Baumann, Christoph, Rudolph, Dorothea, Baumgartinger, Rosa, Strauss, Eva, Haslinger, Christian, Tontsch-Grunt, Ulrike, Waizenegger, Irene C, Solca, Flavio, Bader, Gerd, Zoephel, Andreas, Treu, Matthias, Reiser, Ulrich, Garin-Chesa, Pilar, Boehmelt, Guido, Kraut, Norbert, Quant, Jens, Adolf, Günther R

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Abstract LB003: BI 907828: A highly potent MDM2-p53 antagonist suitable for intermittent dose schedules von Gollner, Andreas, Sini, Patrizia, Rudolph, Dorothea, Weinstabl, Harald, Ramharter, Juergen, Weyer-Czernilofsky, Ulrike, Golubovic, Bojana, Grempler, Rolf, Pitarch, Alejandro Pérez, Sailer, Reinhard, McConnell, Darryl B., Kraut, Norbert

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Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation von Di Fiore, Pier Paolo, Scita, Giorgio, Sini, Patrizia, Cannas, Angela, Koleske, Anthony J

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Inhibition of Multiple Vascular Endothelial Growth Factor Receptors (VEGFR) Blocks Lymph Node Metastases but Inhibition of VEGFR-2 Is Sufficient to Sensitize Tumor Cells to Platinu... von SINI, Patrizia, SAMARZIJA, Ivana, SETYONO-HAN, Buddy, WOOD, Jeanette, HYNES, Nancy E, BAFFERT, Fabienne, LITTLEWOOD-EVANS, Amanda, SCHNELL, Christian, THEUER, Andreas, CHRISTIAN, Sven, BOOS, Anja, HESS-STUMPP, Holger, FOEKENS, John A

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Abstract 1919: Pharmacological characterization of BI 847325, a dual inhibitor of MEK and Aurora kinases von Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K., Boehmelt, Guido, Garin-Chesa, Pilar, Kraut, Nobert, Rudolph, Dorothea, Solca, Flavio, Tontsch-Grunt, Ulrike, Waizenegger, Irene C., Adolf, Günther R.

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Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia von ALFEREZ, DENIS G, GOODLAD, ROBERT A, ODEDRA, RAJESH, SINI, PATRIZIA, CRAFTER, CLAIRE, RYAN, ANDERSON J, WEDGE, STEPHEN R, WRIGHT, NICHOLAS A, ANDERSON, ELIZABETH, WILKINSON, ROBERT W

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An Effector Region in Eps8 Is Responsible for the Activation of the Rac-Specific GEF Activity of Sos-1 and for the Proper Localization of the Rac-Based Actin-Polymerizing Machine von Scita, Giorgio, Tenca, Pierluigi, Areces, Liliana B., Tocchetti, Arianna, Frittoli, Emanuela, Giardina, Giuseppina, Ponzanelli, Isabella, Sini, Patrizia, Innocenti, Metello, Di Fiore, Pier Paolo

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Role of decorin on in vitro fibrillogenesis of type I collagen von Sini, P, Denti, A, Tira, M E, Balduini, C

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ANTICANCER COMBINATION THERAPY von SINI PATRIZIA, ADAM PAUL

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ANTICANCER COMBINATION THERAPY von ADAM, PAUL, SINI, PATRIZIA

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