Discovery and Development of Dolastatin 10-Derived Antibody Drug Conjugate Anticancer Drugs von Singh, Sheo B

Volltext

Discovery, synthesis, activities, structure-activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive review von Singh, Sheo B

Volltext

What is an “ideal” antibiotic? Discovery challenges and path forward von Singh, Sheo B., Young, Katherine, Silver, Lynn L.

Volltext

Confronting the challenges of discovery of novel antibacterial agents von Singh, Sheo B.

Volltext

Discovery and development of kibdelomycin, a new class of broad-spectrum antibiotics targeting the clinically proven bacterial type II topoisomerase von Singh, Sheo B.

Volltext

Discovery and development of first in class antifungal caspofungin (CANCIDAS®)-A case study von Balkovec, James M, Hughes, David L, Masurekar, Prakash S, Sable, Carole A, Schwartz, Robert E, Singh, Sheo B

Volltext

Structures of Kibdelomycin Bound to Staphylococcus aureus GyrB and ParE Showed a Novel U‑Shaped Binding Mode von Lu, Jun, Patel, Sangita, Sharma, Nandini, Soisson, Stephen M, Kishii, Ryuta, Takei, Masaya, Fukuda, Yasumichi, Lumb, Kevin J, Singh, Sheo B

Volltext

Antibacterial and mechanism of action studies of boxazomycin A von Singh, Sheo B., Occi, James, Ondeyka, John, Barrett, John F., Masurekar, Prakash, Motyl, Mary, Gill, Charles, Salituro, Gino

Volltext

History and Prospects of Drug Discovery and Development Collaboration between Industry and Academia von Singh, Sheo B., Martin, Gary E., McKittrick, Brian, Crowther, Jonathan, Fraenkel, Howard, Lunn, Charles, Bayne, Marvin, Perkins, John B., Gullo, Vincent

Volltext

Empirical antibacterial drug discovery—Foundation in natural products von Singh, Sheo B., Barrett, John F.

Volltext

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties von Wang, Jun, Kodali, Srinivas, Lee, Sang Ho, Galgoci, Andrew, Painter, Ronald, Dorso, Karen, Racine, Fred, Motyl, Mary, Hernandez, Lorraine, Tinney, Elizabeth, Colletti, Steven L, Herath, Kithsiri, Cummings, Richard, Salazar, Oscar, González, Ignacio, Basilio, Angela, Vicente, Francisca, Genilloud, Olga, Pelaez, Fernando, Jayasuriya, Hiranthi, Young, Katherine, Cully, Doris F, Singh, Sheo B

Volltext

The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys von Singh, Sheo B, Kang, Ling, Nawrocki, Andrea R, Zhou, Dan, Wu, Margaret, Previs, Stephen, Miller, Corey, Liu, Haiying, Hines, Catherine D G, Madeira, Maria, Cao, Jin, Herath, Kithsiri, Spears, Larry D, Semenkovich, Clay F, Wang, Liangsu, Kelley, David E, Li, Cai, Guan, Hong-Ping

Volltext

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes von Wu, Margaret, Singh, Sheo B, Wang, Jun, Chung, Christine C, Salituro, Gino, Karanam, Bindhu V, Lee, Sang Ho, Powles, Maryann, Ellsworth, Kenneth P, Lassman, Michael E, Miller, Corey, Myers, Robert W, Tota, Michael R, Zhang, Bei B, Li, Cai

Volltext

Kibdelomycin is a bactericidal broad-spectrum aerobic antibacterial agent von Singh, Sheo B, Dayananth, Priya, Balibar, Carl J, Garlisi, Charles G, Lu, Jun, Kishii, Ryuta, Takei, Masaya, Fukuda, Yasumichi, Ha, Sookhee, Young, Katherine

Volltext

Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity von Jayasuriya, Hiranthi, Herath, Kithsiri B., Zhang, Chaowei, Zink, Deborah L., Basilio, Angela, Genilloud, Olga, Diez, Maria Teresa, Vicente, Francisca, Gonzalez, Ignacio, Salazar, Oscar, Pelaez, Fernando, Cummings, Richard, Ha, Sookhee, Wang, Jun, Singh, Sheo B.

Volltext

Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic Clostridioides difficile von Singh, Sheo B, Miesel, Lynn, Kramer, Susanne, Xu, Libo, Li, Fangbio, Lan, Jing, Lipari, Phillip, Polishook, Jon D, Liu, Gongjie, Liang, Lianzhu, Flattery, Amy M

Volltext

Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation von Kondapaka, Sudhir B, Singh, Sheo S, Dasmahapatra, Girija P, Sausville, Edward A, Roy, Krishnendu K

Volltext

Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial... von Singh, Sheo B., Tan, Christopher M., Kaelin, David, Meinke, Peter T., Miesel, Lynn, Olsen, David B., Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Ohata, Kohei, Takeuchi, Tomoko, Shibue, Taku, Takano, Hisashi, Nishimura, Akinori, Fukuda, Yasumichi

Volltext

Rapid, Selective, and Sensitive Method for Semitargeted Discovery of Congeneric Natural Products by Liquid Chromatography Tandem Mass Spectrometry von Herath, Kithsiri B, Previs, Stephen F, Roddy, Thomas P, Attygalle, Athula B, González, Ignacio, Genilloud, Olga, Singh, Sheo B

Volltext

Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy von Singh, Sheo B, Jayasuriya, Hiranthi, Ondeyka, John G, Herath, Kithsiri B, Zhang, Chaowei, Zink, Deborah L, Tsou, Nancy N, Ball, Richard G, Basilio, Angela, Genilloud, Olga, Diez, Maria Teresa, Vicente, Francisca, Pelaez, Fernando, Young, Katherine, Wang, Jun

Volltext