GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile von Dicker, Ira, Jeffrey, Jerry L, Protack, Tricia, Lin, Zeyu, Cockett, Mark, Chen, Yan, Sit, Sing-Yuen, Gartland, Martin, Meanwell, Nicholas A, Regueiro-Ren, Alicia, Drexler, Dieter, Cantone, Joseph, McAuliffe, Brian, Krystal, Mark

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Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage von Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Li, Zhufang, Zhang, Sharon, Sun, Yongnian, Samanta, Himadri, Terry, Brian, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J, Chen, Jie, Venables, Brian L, Healy, Matthew, Meanwell, Nicholas A, Cockett, Mark, Hanumegowda, Umesh, Regueiro-Ren, Alicia, Krystal, Mark, Dicker, Ira B

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Synthesis, Structure–Activity Relationships, and In Vivo Evaluation of Novel C‑17 Amine Derivatives Based on GSK3640254 as HIV‑1 Maturation Inhibitors with Broad Spectrum Activity... von Hartz, Richard A., Xu, Li, Sit, Sing-Yuen, Chen, Jie, Venables, Brian L., Lin, Zeyu, Zhang, Sharon, Li, Zhufang, Parker, Dawn, Simmons, Tara S., Jenkins, Susan, Hanumegowda, Umesh M., Dicker, Ira, Krystal, Mark, Meanwell, Nicholas A., Regueiro-Ren, Alicia

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The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV‑1 Maturation von Regueiro-Ren, Alicia, Sit, Sing-Yuen, Chen, Yan, Chen, Jie, Swidorski, Jacob J., Liu, Zheng, Venables, Brian L., Sin, Ny, Hartz, Richard A., Protack, Tricia, Lin, Zeyu, Zhang, Sharon, Li, Zhufang, Wu, Dauh-Rurng, Li, Peng, Kempson, James, Hou, Xiaoping, Gupta, Anuradha, Rampulla, Richard, Mathur, Arvind, Park, Hyunsoo, Sarjeant, Amy, Benitex, Yulia, Rahematpura, Sandhya, Parker, Dawn, Phillips, Thomas, Haskell, Roy, Jenkins, Susan, Santone, Kenneth S., Cockett, Mark, Hanumegowda, Umesh, Dicker, Ira, Meanwell, Nicholas A., Krystal, Mark

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Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Inf... von Scola, Paul M., Wang, Alan Xiangdong, Good, Andrew C., Sun, Li-Qiang, Combrink, Keith D., Campbell, Jeffrey A., Chen, Jie, Tu, Yong, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley, Zheng, Barbara, Hewawasam, Piyasena, Ding, Min, Thuring, Jan, Li, Jianqing, Hernandez, Dennis, Yu, Fei, Falk, Paul, Zhai, Guangzhi, Sheaffer, Amy K., Chen, Chaoqun, Lee, Min S., Barry, Diana, Knipe, Jay O., Li, Wenying, Han, Yong-Hae, Jenkins, Susan, Gesenberg, Christoph, Gao, Qi, Sinz, Michael W., Santone, Kenneth S., Zvyaga, Tatyana, Rajamani, Ramkumar, Klei, Herbert E., Colonno, Richard J., Grasela, Dennis M., Hughes, Eric, Chien, Caly, Adams, Stephen, Levesque, Paul C., Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona

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The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection von Scola, Paul M., Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Jie, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley V., Zheng, Barbara, Hewawasam, Piyasena, Tu, Yong, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Levine, Steven, Chen, Chaoqun, Yu, Fei, Sheaffer, Amy K., Zhai, Guangzhi, Barry, Diana, Knipe, Jay O., Han, Yong-Hae, Schartman, Richard, Donoso, Maria, Mosure, Kathy, Sinz, Michael W., Zvyaga, Tatyana, Good, Andrew C., Rajamani, Ramkumar, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E., Gao, Qi, Mueller, Luciano, Colonno, Richard J., Grasela, Dennis M., Adams, Stephen P., Loy, James, Levesque, Paul C., Sun, Huabin, Shi, Hong, Sun, Lucy, Warner, William, Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona

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Preclinical Profile of the HIV-1 Maturation Inhibitor VH3739937 von McAuliffe, Brian, Falk, Paul, Chen, Jie, Chen, Yan, Sit, Sing-Yuen, Swidorski, Jacob, Hartz, Richard A, Xu, Li, Venables, Brian, Sin, Ny, Meanwell, Nicholas A, Regueiro-Ren, Alicia, Wensel, David, Hanumegowda, Umesh, Krystal, Mark

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The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation von Chen, Yan, Sit, Sing-Yuen, Chen, Jie, Swidorski, Jacob J., Liu, Zheng, Sin, Ny, Venables, Brian L., Parker, Dawn D., Nowicka-Sans, Beata, Lin, Zeyu, Li, Zhufang, Terry, Brian J., Protack, Tricia, Rahematpura, Sandhya, Hanumegowda, Umesh, Jenkins, Susan, Krystal, Mark, Dicker, Ira D., Meanwell, Nicholas A., Regueiro-Ren, Alicia

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Inhibitors of HIV-1 maturation: Development of structure–activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids von Swidorski, Jacob J., Liu, Zheng, Sit, Sing-Yuen, Chen, Jie, Chen, Yan, Sin, Ny, Venables, Brian L., Parker, Dawn D., Nowicka-Sans, Beata, Terry, Brian J., Protack, Tricia, Rahematpura, Sandhya, Hanumegowda, Umesh, Jenkins, Susan, Krystal, Mark, Dicker, Ira B., Meanwell, Nicholas A., Regueiro-Ren, Alicia

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Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors von Wu, Yong-Jin, Venables, Brian, Guernon, Jason, Chen, Jie, Sit, Sing-Yuen, Rajamani, Ramkumar, Knox, Ronald J., Matchett, Michele, Pieschl, Rick L., Herrington, James, Bristow, Linda J., Meanwell, Nicholas A., Thompson, Lorin A., Dzierba, Carolyn

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Discovery of BMS-955176, a Second Generation HIV‑1 Maturation Inhibitor with Broad Spectrum Antiviral Activity von Regueiro-Ren, Alicia, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Swidorski, Jacob J, Chen, Jie, Venables, Brian L, Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Beno, Brett R, Huang, Xiaohua S, Rahematpura, Sandhya, Parker, Dawn D, Haskell, Roy, Jenkins, Susan, Santone, Kenneth S, Cockett, Mark I, Krystal, Mark, Meanwell, Nicholas A, Hanumegowda, Umesh, Dicker, Ira B

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Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)... von Regueiro-Ren, Alicia, Swidorski, Jacob J, Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Chen, Jie, Venables, Brian L, Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Easter, John, Beno, Brett R, Arora, Vinod, Huang, Xiaohua S, Rahematpura, Sandhya, Parker, Dawn D, Haskell, Roy, Santone, Kenneth S, Cockett, Mark I, Krystal, Mark, Meanwell, Nicholas A, Jenkins, Susan, Hanumegowda, Umesh, Dicker, Ira B

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Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing von Sun, Li-Qiang, Mull, Eric, Zheng, Barbara, D’Andrea, Stanley, Zhao, Qian, Wang, Alan Xiangdong, Sin, Ny, Venables, Brian L, Sit, Sing-Yuen, Chen, Yan, Chen, Jie, Cocuzza, Anthony, Bilder, Donna M, Mathur, Arvind, Rampulla, Richard, Chen, Bang-Chi, Palani, Theerthagiri, Ganesan, Sivakumar, Arunachalam, Pirama Nayagam, Falk, Paul, Levine, Steven, Chen, Chaoqun, Friborg, Jacques, Yu, Fei, Hernandez, Dennis, Sheaffer, Amy K, Knipe, Jay O, Han, Yong-Hae, Schartman, Richard, Donoso, Maria, Mosure, Kathy, Sinz, Michael W, Zvyaga, Tatyana, Rajamani, Ramkumar, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E, Gao, Qi, Ng, Alicia, Mueller, Luciano, Grasela, Dennis M, Adams, Stephen, Loy, James, Levesque, Paul C, Sun, Huabin, Shi, Hong, Sun, Lucy, Warner, William, Li, Danshi, Zhu, Jialong, Wang, Ying-Kai, Fang, Hua, Cockett, Mark I, Meanwell, Nicholas A, McPhee, Fiona, Scola, Paul M

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3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction von BOY, Kenneth M, GUERNON, Jason M, STARRETT, John E, SIT, Sing-Yuen, XIE, Kai, HEWAWASAM, Piyasena, BOISSARD, Christopher G, DWORETZKY, Steven I, NATALE, Joanne, GRIBKOFF, Valentin K, LODGE, Nicholas

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Synthesis and SAR exploration of dinapsoline analogues von Sit, Sing-Yuen, Xie, Kai, Jacutin-Porte, Swanee, Boy, Kenneth M, Seanz, James, Taber, Matthew T, Gulwadi, Amit G, Korpinen, Carolyn D, Burris, Kevin D, Molski, Thaddeus F, Ryan, Elaine, Xu, Cen, Verdoorn, Todd, Johnson, Graham, Nichols, David E, Mailman, Richard B

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Novel Dihydropyrazine Analogues as NPY Antagonists von Sit, Sing-Yuen, Huang, Yazhong, Antal-Zimanyi, Ildiko, Ward, Sally, Poindexter, Graham S

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(+)-Dinapsoline:  An Efficient Synthesis and Pharmacological Profile of a Novel Dopamine Agonist von Sit, Sing-Yuen, Xie, Kai, Jacutin-Porte, Swanee, Taber, Matthew T, Gulwadi, Amit G, Korpinen, Carolyn D, Burris, Kevin D, Molski, Thaddeus F, Ryan, Elaine, Xu, Cen, Wong, Henry, Zhu, Juliang, Krishnananthan, Subramaniam, Gao, Qi, Verdoorn, Todd, Johnson, Graham

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Design, Synthesis, and SAR of C‑3 Benzoic Acid, C‑17 Triterpenoid Derivatives. Identification of the HIV‑1 Maturation Inhibitor 4‑((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)‑3a-((2-(... von Regueiro-Ren, Alicia, Swidorski, Jacob J., Liu, Zheng, Chen, Yan, Sin, Ny, Sit, Sing-Yuen, Chen, Jie, Venables, Brian L., Zhu, Juliang, Nowicka-Sans, Beata, Protack, Tricia, Lin, Zeyu, Terry, Brian, Samanta, Himadri, Zhang, Sharon, Li, Zhufang, Easter, John, Beno, Brett R., Arora, Vinod, Huang, Xiaohua S., Rahematpura, Sandhya, Parker, Dawn D., Haskell, Roy, Santone, Kenneth S., Cockett, Mark I., Krystal, Mark, Meanwell, Nicholas A., Jenkins, Susan, Hanumegowda, Umesh, Dicker, Ira B.

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Invention of VH-937, a Potent HIV‑1 Maturation Inhibitor with the Potential for Infrequent Oral Dosing in Humans von Sit, Sing-Yuen, Chen, Yan, Chen, Jie, Venables, Brian L., Swidorski, Jacob J., Xu, Li, Sin, Ny, Hartz, Richard A., Lin, Zeyu, Zhang, Sharon, Li, Zhufang, Wu, Dauh-Rurng, Li, Peng, Kempson, James, Hou, Xiaoping, Shanmugam, Yoganand, Parker, Dawn, Jenkins, Susan, Simmermacher, Jean, Falk, Paul, McAuliffe, Brian, Cockett, Mark, Hanumegowda, Umesh, Dicker, Ira, Krystal, Mark, Meanwell, Nicholas A., Regueiro-Ren, Alicia

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3-Hydroxy-quinolin-2-ones: Inhibitors of [ 3H]-glycine binding to the site associated with the NMDA receptor von Sit, Sing-Yuen, Ehrgott, Frederick J., Gao, Jinnian, Meanwell, Nicholas A.

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