Minimal modification in the factor VIII B-domain sequence ameliorates the murine hemophilia A phenotype von Siner, Joshua I., Iacobelli, Nicholas P., Sabatino, Denise E., Ivanciu, Lacramiora, Zhou, Shangzhen, Poncz, Mortimer, Camire, Rodney M., Arruda, Valder R.

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AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice von Crudele, Julie M., Finn, Jonathan D., Siner, Joshua I., Martin, Nicholas B., Niemeyer, Glenn P., Zhou, Shangzhen, Mingozzi, Federico, Lothrop, Clinton D., Arruda, Valder R.

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Safety of Liver Gene Transfer Following Peripheral Intravascular Delivery of Adeno-Associated Virus (AAV)-5 and AAV-6 in a Large Animal Model von FAVARO, Patricia, FINN, Jonathan D, SINER, Joshua I, FRASER WRIGHT, J, HIGH, Katherine A, ARRUDA, Valder R

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Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models von Siner, Joshua I, Samelson-Jones, Benjamin J, Crudele, Julie M, French, Robert A, Lee, Benjamin J, Zhou, Shanzhen, Merricks, Elizabeth, Raymer, Robin, Nichols, Timothy C, Camire, Rodney M, Arruda, Valder R

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AAV gene therapy in companion dogs with severe hemophilia: Real-world long-term data on immunogenicity, efficacy, and quality of life von Doshi, Bhavya S., Samelson-Jones, Benjamin J., Nichols, Timothy C., Merricks, Elizabeth P., Siner, Joshua I., French, Robert A., Lee, Ben J., Arruda, Valder R., Callan, Mary Beth

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Human Factor VIII Variants with Diminished PACE-Furin Cleavage Exhibit Increased Biological Activity and Therapeutic Efficacy von Nguyen, Giang N., Siner, Joshua I., Davidson, Robert J., Arruda, Valder R., Camire, Rodney M., Sabatino, Denise E.

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Unexpected Role of PACE/Furin Cleavage Site in FVIII Biology: Implications for Hemophilia a Therapy von Siner, Joshua I, Crudele, Julie M, Connolly, Courtney T, Zhou, Shangzhen, Merricks, Elizabeth P., Nichols, Timothy C., Camire, Rodney M., Arruda, Valder R.

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Bioengineering Factor VIII B-Domain Sequences Improves Function and Efficacy in Hemophilia A Models von Siner, Joshua I, Iacobelli, Nicholas P, Ivanciu, Lacramioara, Sabatino, Denise E., Poncz, Mortimer, Camire, Rodney M., Arruda, Valder R

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Tolerance Induction To FIX Padua With AAV Liver Gene Transfer In Inhibitor-Prone Hemophilia B Dogs von Crudele, Julie M, Finn, Jonathan D, Martin, Nicholas B, Siner, Joshua I, Chen, Yifeng, Zhou, Shangzhen, Niemeyer, Glenn, Lothrop, Clinton D., Mingozzi, Federico, High, Katherine A., Arruda, Valder R.

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Insights Into the Mechanism of Zymogen Protein C Protection Against Cancer Progression von Crudele, Julie M, Van Sluis, Geerte L., Margaritis, Paris, Siner, Joshua I, Sliozberg, Michael, Maurer, Jenna, Faella, Armida, Zhou, Shangzhen, High, Katherine A., Esmon, Charles T, Spek, C. Arnold, Arruda, Valder R

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DANGEROUS DROPS: A CASE OF HOMEOPATHIC DIGITALIS von Mock, Gabrielle, Frenchu, Kiersten, Siner, Joshua

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Enteral Feeding during Indomethacin and Ibuprofen Treatment of a Patent Ductus Arteriosus von Clyman, Ronald, MD, Wickremasinghe, Andrea, MD, Jhaveri, Nami, MD, Hassinger, Denise C., MD, Attridge, Joshua T., MD, Sanocka, Ulana, MD, Polin, Richard, MD, Gillam-Krakauer, Maria, MD, Reese, Jeff, MD, Mammel, Mark, MD, Couser, Robert, MD, Mulrooney, Neil, MD, Yanowitz, Toby D., MD, Derrick, Matthew, MD, Jegatheesan, Priya, MD, Walsh, Michele, MD, Fujii, Alan, MD, Porta, Nicolas, MD, Carey, William A., MD, Swanson, Jonathan R., MD

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Protease-Activated Receptor 4 (PAR4) Plays a Critical Role in Fetal Loss and Peripheral Thrombosis in a Mouse Model of Thrombophilia von Siner, Joshua, Freguia, Christian Furlan, Maiden, Michael, Liu, Jianhua, Baila, Stefano, Arruda, Valder

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