Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion von Mouneimne, Ghassan, Hansen, Scott D., Selfors, Laura M., Petrak, Lara, Hickey, Michele M., Gallegos, Lisa L., Simpson, Kaylene J., Lim, James, Gertler, Frank B., Hartwig, John H., Mullins, R. Dyche, Brugge, Joan S.

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Identification of genes that regulate epithelial cell migration using an siRNA screening approach von Brugge, Joan S, Simpson, Kaylene J, Selfors, Laura M, Bui, James, Reynolds, Angela, Leake, Devin, Khvorova, Anastasia

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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer von Vervoort, Stephin J., Welsh, Sarah A., Devlin, Jennifer R., Barbieri, Elisa, Knight, Deborah A., Offley, Sarah, Bjelosevic, Stefan, Costacurta, Matteo, Todorovski, Izabela, Kearney, Conor J., Sandow, Jarrod J., Fan, Zheng, Blyth, Benjamin, McLeod, Victoria, Vissers, Joseph H.A., Pavic, Karolina, Martin, Ben P., Gregory, Gareth, Demosthenous, Elena, Zethoven, Magnus, Kong, Isabella Y., Hawkins, Edwin D., Hogg, Simon J., Kelly, Madison J., Newbold, Andrea, Simpson, Kaylene J., Kauko, Otto, Harvey, Kieran F., Ohlmeyer, Michael, Westermarck, Jukka, Gray, Nathanael, Gardini, Alessandro, Johnstone, Ricky W.

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A functional genetic screen defines the AKT-induced senescence signaling network von Chan, Keefe T., Blake, Shaun, Zhu, Haoran, Kang, Jian, Trigos, Anna S., Madhamshettiwar, Piyush B., Diesch, Jeannine, Paavolainen, Lassi, Horvath, Peter, Hannan, Ross D., George, Amee J., Sanij, Elaine, Hannan, Katherine M., Simpson, Kaylene J., Pearson, Richard B.

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Generation of a functional mammary gland from a single stem cell von Stingl, John, Visvader, Jane E, Shackleton, Mark, Wu, Li, Vaillant, François, Simpson, Kaylene J, Asselin-Labat, Marie-Liesse, Smyth, Gordon K, Lindeman, Geoffrey J

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Genes regulating membrane-associated E-cadherin and proliferation in adenomatous polyposis coli mutant colon cancer cells: High content siRNA screen von King, Lauren E., Zhang, Hui-Hua, Gould, Cathryn M., Thomas, Daniel W., Whitehead, Lachlan W., Simpson, Kaylene J., Burgess, Antony W., Faux, Maree C.

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MAC-Seq: Coupling Low-Cost, High-Throughput RNA-Seq with Image-Based Phenotypic Screening in 2D and 3D Cell Models von Li, Xiang Mark, Yoannidis, David, Ramm, Susanne, Luu, Jennii, Arnau, Gisela Mir, Semple, Timothy, Simpson, Kaylene J.

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Loss of HPV type 16 E7 restores cGAS-STING responses in human papilloma virus-positive oropharyngeal squamous cell carcinomas cells von Bortnik, Vuk, Wu, Michelle, Julcher, Bryan, Salinas, Ana, Nikolic, Iva, Simpson, Kaylene J., McMillan, Nigel AJ, Idris, Adi

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FOXO3a Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases von Storz, Peter, Döppler, Heike, Copland, John A., Simpson, Kaylene J., Toker, Alex

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FGFR3 signaling and function in triple negative breast cancer von Chew, Nicole J., Nguyen, Elizabeth V., Su, Shih-Ping, Novy, Karel, Chan, Howard C., Nguyen, Lan K., Luu, Jennii, Simpson, Kaylene J., Lee, Rachel S., Daly, Roger J.

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Genome-wide siRNA Screening at Biosafety Level 4 Reveals a Crucial Role for Fibrillarin in Henipavirus Infection von Deffrasnes, Celine, Marsh, Glenn A, Foo, Chwan Hong, Rootes, Christina L, Gould, Cathryn M, Grusovin, Julian, Monaghan, Paul, Lo, Michael K, Tompkins, S Mark, Adams, Timothy E, Lowenthal, John W, Simpson, Kaylene J, Stewart, Cameron R, Bean, Andrew G D, Wang, Lin-Fa

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Functional high-throughput screen identifies microRNAs that promote butyrate-induced death in colorectal cancer cells von Ali, Saira R., Humphreys, Karen J., Simpson, Kaylene.J., McKinnon, Ross A., Meech, Robyn, Michael, Michael Z.

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Lysosomal degradation products induce Coxiella burnetii virulence von Newton, Patrice, Thomas, David R., Reed, Shawna C. O., Lau, Nicole, Xu, Bangyan, Ong, Sze Ying, Pasricha, Shivani, Madhamshettiwar, Piyush B., Edgington-Mitchell, Laura E., Simpson, Kaylene J., Roy, Craig R., Newton, Hayley J.

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Synthetic lethality between CCNE1 amplification and loss of BRCA1 von Etemadmoghadam, Dariush, Weir, Barbara A., Au-Yeung, George, Alsop, Kathryn, Mitchell, Gillian, George, Joshy, Davis, Sally, D'Andrea, Alan D., Simpson, Kaylene, Hahn, William C., Bowtell, David D. L.

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Next Generation Cell Culture Tools Featuring Micro‐ and Nanotopographies for Biological Screening von Carthew, James, Abdelmaksoud, Hazem H., Cowley, Karla J., Hodgson‐Garms, Margeaux, Elnathan, Roey, Spatz, Joachim P., Brugger, Juergen, Thissen, Helmut, Simpson, Kaylene J., Voelcker, Nicolas H., Frith, Jessica E., Cadarso, Victor J.

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Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma von Smith, Lorey K., Parmenter, Tiffany, Kleinschmidt, Margarete, Kusnadi, Eric P., Kang, Jian, Martin, Claire A., Lau, Peter, Patel, Riyaben, Lorent, Julie, Papadopoli, David, Trigos, Anna, Ward, Teresa, Rao, Aparna D., Lelliott, Emily J., Sheppard, Karen E., Goode, David, Hicks, Rodney J., Tiganis, Tony, Simpson, Kaylene J., Larsson, Ola, Blythe, Benjamin, Cullinane, Carleen, Wickramasinghe, Vihandha O., Pearson, Richard B., McArthur, Grant A.

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SLC7A11 Is a Superior Determinant of APR-246 (Eprenetapopt) Response than TP53 Mutation Status von Fujihara, Kenji M., Benitez, Mariana Corrales, Cabalag, Carlos S., Zhang, Bonnie Z., Ko, Hyun S., Liu, David S., Simpson, Kaylene J., Haupt, Ygal, Lipton, Lara, Haupt, Sue, Phillips, Wayne A., Clemons, Nicholas J.

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MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer von Lin, Hui-Ming, Nikolic, Iva, Yang, Jessica, Castillo, Lesley, Deng, Niantao, Chan, Chia-Ling, Yeung, Nicole K., Dodson, Eoin, Elsworth, Benjamin, Spielman, Calan, Lee, Brian Y., Boyer, Zoe, Simpson, Kaylene J., Daly, Roger J., Horvath, Lisa G., Swarbrick, Alexander

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A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death von Ceder, Sophia, Eriksson, Sofi E, Cheteh, Emarndeena H, Dawar, Swati, Corrales Benitez, Mariana, Bykov, Vladimir J N, Fujihara, Kenji M, Grandin, Mélodie, Li, Xiaodun, Ramm, Susanne, Behrenbruch, Corina, Simpson, Kaylene J, Hollande, Frédéric, Abrahmsen, Lars, Clemons, Nicholas J, Wiman, Klas G

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Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation von Ma, Xiuquan, Zhang, Luxi, Song, Jiangning, Nguyen, Elizabeth, Lee, Rachel S., Rodgers, Samuel J., Li, Fuyi, Huang, Cheng, Schittenhelm, Ralf B., Chan, Howard, Chheang, Chanly, Wu, Jianmin, Brown, Kristin K., Mitchell, Christina A., Simpson, Kaylene J., Daly, Roger J.

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