The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis von Lucas, Jared M, Heinlein, Cynthia, Kim, Tom, Hernandez, Susana A, Malik, Muzdah S, True, Lawrence D, Morrissey, Colm, Corey, Eva, Montgomery, Bruce, Mostaghel, Elahe, Clegg, Nigel, Coleman, Ilsa, Brown, Christopher M, Schneider, Eric L, Craik, Charles, Simon, Julian A, Bedalov, Antonio, Nelson, Peter S

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Phenotypic Optimization of Urea–Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss von Chowdhury, Sarwat, Owens, Kelly N, Herr, R. Jason, Jiang, Qin, Chen, Xinchao, Johnson, Graham, Groppi, Vincent E, Raible, David W, Rubel, Edwin W, Simon, Julian A

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Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity von Davis, Samantha N., Wu, Patricia, Camci, Esra D., Simon, Julian A., Rubel, Edwin W., Raible, David W.

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Tailored magnetic nanoparticles for optimizing magnetic fluid hyperthermia von Khandhar, Amit P., Ferguson, R. Matthew, Simon, Julian A., Krishnan, Kannan M.

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Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death von Owens, Kelly N, Santos, Felipe, Roberts, Brock, Linbo, Tor, Coffin, Allison B, Knisely, Anna J, Simon, Julian A, Rubel, Edwin W, Raible, David W

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Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies von Chowdhury, Sarwat, Sripathy, Smitha, Webster, Alyssa, Park, Angela, Lao, Uyen, Hsu, Joanne H, Loe, Taylor, Bedalov, Antonio, Simon, Julian A

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A Proteomic Investigation of Ligand-dependent HSP90 Complexes Reveals CHORDC1 as a Novel ADP-dependent HSP90-interacting Protein von Gano, Jacob J., Simon, Julian A.

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Long-term tracking demonstrates effectiveness of a partnership-led training program to advance the careers of biomedical researchers from underrepresented groups von Thompson, Beti, O'Connell, Mary A, Peterson, Karen, Shuster, Michele, Drennan, Marilyn, Loest, Helena, Holte, Sarah, Simon, Julian A, Unguez, Graciela A

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Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes von HELTWEG, Birgit, GATBONTON, Tonibelle, BEDALOV, Antonio, SCHULER, Aaron D, POSAKONY, Jeff, HONGZHE LI, GOEHLE, Sondra, KOLLIPARA, Ramya, DEPINHO, Ronald A, YANSONG GU, SIMON, Julian A

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Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action von Wu, Patricia, Barros-Becker, Francisco, Ogelman, Roberto, Camci, Esra D, Linbo, Tor H, Simon, Julian A, Rubel, Edwin W, Raible, David W

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Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin von Jacquemont, Céline, Simon, Julian A, D'Andrea, Alan D, Taniguchi, Toshiyasu

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An in vivo Biomarker to Characterize Ototoxic Compounds and Novel Protective Therapeutics von Bellairs, Joseph A, Redila, Van A, Wu, Patricia, Tong, Ling, Webster, Alyssa, Simon, Julian A, Rubel, Edwin W, Raible, David W

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Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast von Gatbonton, Tonibelle, Imbesi, Maria, Nelson, Melisa, Akey, Joshua M, Ruderfer, Douglas M, Kruglyak, Leonid, Simon, Julian A, Bedalov, Antonio

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Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model von Leko, Vid, Park, Gemma J, Lao, Uyen, Simon, Julian A, Bedalov, Antonio

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Identification of a Small Molecule Inhibitor of Sir2p von Bedalov, Antonio, Gatbonton, Tonibelle, Irvine, William P., Gottschling, Daniel E., Simon, Julian A.

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Hair Cell Toxicity in Anti-cancer Drugs: Evaluating an Anti-cancer Drug Library for Independent and Synergistic Toxic Effects on Hair Cells Using the Zebrafish Lateral Line von Hirose, Yoshinobu, Simon, Julian A., Ou, Henry C.

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Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis von Tang, Xi, Mahajan, Sumit S, Nguyen, Liem T, Béliveau, François, Leduc, Richard, Simon, Julian A, Vasioukhin, Valeri

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A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities von Handeli, Shlomo, Simon, Julian A.

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The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion von Dembitz, Vilma, Tomic, Barbara, Kodvanj, Ivan, Simon, Julian A., Bedalov, Antonio, Visnjic, Dora

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Chemical Screening for Hair Cell Loss and Protection in the Zebrafish Lateral Line von Coffin, Allison B., Ou, Henry, Owens, Kelly N., Santos, Felipe, Simon, Julian A., Rubel, Edwin W, Raible, David W.

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