Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria von Balwani, Manisha, Sardh, Eliane, Ventura, Paolo, Peiró, Paula Aguilera, Rees, David C, Stölzel, Ulrich, Bissell, D. Montgomery, Bonkovsky, Herbert L, Windyga, Jerzy, Anderson, Karl E, Parker, Charles, Silver, Samuel M, Keel, Siobán B, Wang, Jiaan-Der, Stein, Penelope E, Harper, Pauline, Vassiliou, Daphne, Wang, Bruce, Phillips, John, Ivanova, Aneta, Langendonk, Janneke G, Kauppinen, Raili, Minder, Elisabeth, Horie, Yutaka, Penz, Craig, Chen, Jihong, Liu, Shangbin, Ko, John J, Sweetser, Marianne T, Garg, Pushkal, Vaishnaw, Akshay, Kim, Jae B, Simon, Amy R, Gouya, Laurent

Volltext

Phase 1 Trial of an RNA Interference Therapy for Acute Intermittent Porphyria von Sardh, Eliane, Harper, Pauline, Balwani, Manisha, Stein, Penelope, Rees, David, Bissell, D. Montgomery, Desnick, Robert, Parker, Charles, Phillips, John, Bonkovsky, Herbert L, Vassiliou, Daphne, Penz, Craig, Chan-Daniels, Amy, He, Qiuling, Querbes, William, Fitzgerald, Kevin, Kim, Jae B, Garg, Pushkal, Vaishnaw, Akshay, Simon, Amy R, Anderson, Karl E

Volltext

ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients von Gottlieb, Jens, MD, Zamora, Martin R., MD, Hodges, Tony, MD, Musk, A.W., MD, Sommerwerk, Urte, MD, Dilling, Daniel, MD, FACP, Arcasoy, Selim, MD, DeVincenzo, John, MD, Karsten, Verena, PhD, Shah, Shaily, Bettencourt, Brian R., PhD, Cehelsky, Jeffrey, MBA, Nochur, Sara, PhD, Gollob, Jared, MD, Vaishnaw, Akshay, MD, Simon, Amy R., MD, Glanville, Allan R., MD, MBBS

Volltext

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia von Sehgal, Alfica, Barros, Scott, Ivanciu, Lacramioara, Cooley, Brian, Qin, June, Racie, Tim, Hettinger, Julia, Carioto, Mary, Jiang, Yongfeng, Brodsky, Josh, Prabhala, Harsha, Zhang, Xuemei, Attarwala, Husain, Hutabarat, Renta, Foster, Don, Milstein, Stuart, Charisse, Klaus, Kuchimanchi, Satya, Maier, Martin A, Nechev, Lubo, Kandasamy, Pachamuthu, Kel'in, Alexander V, Nair, Jayaprakash K, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Meyers, Rachel, Sorensen, Benny, Simon, Amy R, Dargaud, Yesim, Negrier, Claude, Camire, Rodney M, Akinc, Akin

Volltext

Airway Epithelial STAT3 Is Required for Allergic Inflammation in a Murine Model of Asthma von Simeone-Penney, Marina C, Severgnini, Mariano, Tu, Powen, Homer, Robert J, Mariani, Thomas J, Cohn, Lauren, Simon, Amy R

Volltext

Pharmacokinetics and Pharmacodynamics of the Small Interfering Ribonucleic Acid, Givosiran, in Patients With Acute Hepatic Porphyria von Agarwal, Sagar, Simon, Amy R., Goel, Varun, Habtemariam, Bahru A., Clausen, Valerie A., Kim, Jae B., Robbie, Gabriel J.

Volltext

Activation of the JAK-STAT pathway by reactive oxygen species von Simon, Amy R, Rai, Usha, Fanburg, Barry L, Cochran, Brent H

Volltext

PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1 von Simeone-Penney, Marina C, Severgnini, Mariano, Rozo, Lilliana, Takahashi, Satoe, Cochran, Brent H, Simon, Amy R

Volltext

Anthracycline-Induced Suppression of GATA-4 Transcription Factor: Implication in the Regulation of Cardiac Myocyte Apoptosis von Kim, Yuri, Ma, Ai-Guo, Kitta, Kazumi, Fitch, Sarah N, Ikeda, Takayuki, Ihara, Yoshiharu, Simon, Amy R, Evans, Todd, Suzuki, Yuichiro J

Volltext

Activation of the STAT pathway in acute lung injury von Severgnini, Mariano, Takahashi, Satoe, Rozo, Liliana M, Homer, Robert J, Kuhn, Charles, Jhung, Jhung W, Perides, George, Steer, Michael, Hassoun, Paul M, Fanburg, Barry L, Cochran, Brent H, Simon, Amy R

Volltext

A Drug‐Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid, on Cytochrome P450 Activity in the Liver von Vassiliou, Daphne, Sardh, Eliane, Harper, Pauline, Simon, Amy R., Clausen, Valerie A., Najafian, Nader, Robbie, Gabriel J., Agarwal, Sagar

Volltext

Regulation of STAT3 by Direct Binding to the Rac1 GTPase von Simon, Amy R., Vikis, Haris G., Stewart, Scott, Fanburg, Barry L., Cochran, Brent H., Guan, Kun-Liang

Volltext

Inhibition of the Src and Jak Kinases Protects against Lipopolysaccharide-induced Acute Lung Injury von Severgnini, Mariano, Takahashi, Satoe, Tu, Powen, Perides, George, Homer, Robert J, Jhung, Jhung W, Bhavsar, Deepa, Cochran, Brent H, Simon, Amy R

Volltext

Role of the JAK-STAT pathway in PDGF-stimulated proliferation of human airway smooth muscle cells von Simon, Amy R, Takahashi, Satoe, Severgnini, Mariano, Fanburg, Barry L, Cochran, Brent H

Volltext

GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38 von Zhong, Jian, Gavrilescu, L. Cristina, Molnár, Árpád, Murray, Lauren, Garafalo, Stephen, Kehrl, John H, Simon, Amy R, Van Etten, Richard A, Kyriakis, John M

Volltext

Normal reference ranges for urinary δ‐aminolevulinic acid and porphobilinogen levels von Agarwal, Sagar, Habtemarium, Bahru, Xu, Yuanxin, Simon, Amy R., Kim, Jae B., Robbie, Gabriel J.

Volltext

Retraction for Zhong et al., GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38 von Gavrilescu, L Cristina, Molnár, Árpád, Murray, Lauren, Garafalo, Stephen, Kehrl, John H, Simon, Amy R, Van Etten, Richard A, Kyriakis, John M

Volltext

5-HT induction of c-fos gene expression requires reactive oxygen species and Rac1 and Ras GTPases von Simon, Amy R, Severgnini, Mariano, Takahashi, Satoe, Rozo, Liliana, Andrahbi, Bathsheeba, Agyeman, Abena, Cochran, Brent H, Day, Regina M, Fanburg, Barry L

Volltext

RETRACTED: GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38 von Zhong, Jian, Gavrilescu, L. Cristina, Molnár, Árpád, Murray, Lauren, Garafalo, Stephen, Kehrl, John H., Simon, Amy R., Van Etten, Richard A., Kyriakis, John M.

Volltext

RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION von Jadhav, Vasant R, Simon, Amy R, Foster, Donald, Brown, Christopher, Akinc, Akin, Rogers, Arlin

Volltext bestellen