Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis von McKenna, Michael, Simmonds, Rachel E, High, Stephen

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The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER von Hall, Belinda S, Hill, Kirsti, McKenna, Michael, Ogbechi, Joy, High, Stephen, Willis, Anne E, Simmonds, Rachel E

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Structure of the Inhibited State of the Sec Translocon von Gérard, Samuel F., Hall, Belinda S., Zaki, Afroditi M., Corfield, Katherine A., Mayerhofer, Peter U., Costa, Catia, Whelligan, Daniel K., Biggin, Philip C., Simmonds, Rachel E., Higgins, Matthew K.

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Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state von Bhadra, Pratiti, Dos Santos, Scott, Gamayun, Igor, Pick, Tillman, Neumann, Clarissa, Ogbechi, Joy, Hall, Belinda S, Zimmermann, Richard, Helms, Volkhard, Simmonds, Rachel E, Cavalié, Adolfo

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Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4 von Ogbechi, Joy, Hall, Belinda S., Sbarrato, Thomas, Taunton, Jack, Willis, Anne E., Wek, Ronald C., Simmonds, Rachel E.

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Editorial: Host-pathogen interactions in nontuberculous mycobacterial infections von Lorè, Nicola Ivan, Yamasaki, Sho, Simmonds, Rachel E, Jo, Eun-Kyeong

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The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer von Hall, Belinda S, Hsieh, Louise Tzung-Harn, Sacre, Sandra, Simmonds, Rachel E

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Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone von McKenna, Michael, Simmonds, Rachel E, High, Stephen

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Transient up-regulation of miR-155-3p by lipopolysaccharide in primary human monocyte-derived macrophages results in RISC incorporation but does not alter TNF expression von Simmonds, Rachel E.

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Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions von Hsieh, Louise Tzung-Harn, Dos Santos, Scott J, Hall, Belinda S, Ogbechi, Joy, Loglo, Aloysius D, Salguero, Francisco Javier, Ruf, Marie-Thérèse, Pluschke, Gerd, Simmonds, Rachel E

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Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions von Ogbechi, Joy, Ruf, Marie-Thérèse, Hall, Belinda S, Bodman-Smith, Katherine, Vogel, Moritz, Wu, Hua-Lin, Stainer, Alexander, Esmon, Charles T, Ahnström, Josefin, Pluschke, Gerd, Simmonds, Rachel E

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Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F von O'Keefe, Sarah, Bhadra, Pratiti, Duah, Kwabena B, Zong, Guanghui, Tenay, Levise, Andrews, Lauren, Schneider, Hayden, Anderson, Ashley, Hu, Zhijian, Aljewari, Hazim S, Hall, Belinda S, Simmonds, Rachel E, Helms, Volkhard, High, Stephen, Shi, Wei Q

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Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism von Simmonds, Rachel E, Lali, Ferdinand V, Smallie, Tim, Small, Pamela L. C, Foxwell, Brian M

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Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures von Sacre, Sandra M, Lo, Alexandra, Gregory, Bernard, Simmonds, Rachel E, Williams, Lynn, Feldmann, Marc, Brennan, Fionula M, Foxwell, Brian M

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Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease von Sarfo, Fred Stephen, Phillips, Richard, Wansbrough‐Jones, Mark, Simmonds, Rachel E.

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Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity von Hall, Belinda S, Dos Santos, Scott J, Hsieh, Louise Tzung-Harn, Manifava, Maria, Ruf, Marie-Thérèse, Pluschke, Gerd, Ktistakis, Nicholas, Simmonds, Rachel E

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Buruli Ulcer: a Review of the Current Knowledge von Yotsu, Rie R., Suzuki, Koichi, Simmonds, Rachel E., Bedimo, Roger, Ablordey, Anthony, Yeboah-Manu, Dorothy, Phillips, Richard, Asiedu, Kingsley

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Transient up-regulation of miR-155-3p by lipopolysaccharide in primary human monocyte-derived macrophages results in RISC incorporation but does not alter TNF expression von Simmonds, Rachel E

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Understanding the transmission of Mycobacterium ulcerans: A step towards controlling Buruli ulcer von Muleta, Anthony J, Lappan, Rachael, Stinear, Timothy P, Greening, Chris

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A systematic review and meta-analysis of the association between neglected tropical diseases and malnutrition: more research needed on diseases other than intestinal parasites, lei... von Loglo, Aloysius, Aniagyei, Wilfred, Vivekanandan, Monika Mira, Agbanyo, Abigail, Asamoah, Evans Adu, Phillips, Richard O, Annan, Reginald, Engel, Barbara, Simmonds, Rachel E

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