Development of inhibitors in the ubiquitination cascade von Zhang, Wei, Sidhu, Sachdev S.

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Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation von Yamaguchi, Masaya, VanderLinden, Ryan, Weissmann, Florian, Qiao, Renping, Dube, Prakash, Brown, Nicholas G., Haselbach, David, Zhang, Wei, Sidhu, Sachdev S., Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

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Comprehensive Analysis of the Human SH3 Domain Family Reveals a Wide Variety of Non-canonical Specificities von Teyra, Joan, Huang, Haiming, Jain, Shobhit, Guan, Xinyu, Dong, Aiping, Liu, Yanli, Tempel, Wolfram, Min, Jinrong, Tong, Yufeng, Kim, Philip M., Bader, Gary D., Sidhu, Sachdev S.

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The Importance of Being Tyrosine: Lessons in Molecular Recognition from Minimalist Synthetic Binding Proteins von Koide, Shohei, Sidhu, Sachdev S

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Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims von Kini, R Manjunatha, Sidhu, Sachdev S, Laustsen, Andreas Hougaard

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Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling von Oka, Tsutomu, Remue, Eline, Meerschaert, Kris, Vanloo, Berlinda, Boucherie, Ciska, Gfeller, David, Bader, Gary D, Sidhu, Sachdev S, Vandekerckhove, Joël, Gettemans, Jan, Sudol, Marius

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Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress von Liang, Jingjing, Sagum, Cari A, Bedford, Mark T, Sidhu, Sachdev S, Sudol, Marius, Han, Ziying, Harty, Ronald N

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Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1–F-box interface von Gorelik, Maryna, Orlicky, Stephen, Sartori, Maria A., Tang, Xiaojing, Marcon, Edyta, Kurinov, Igor, Greenblatt, Jack F., Tyers, Mike, Moffat, Jason, Sicheri, Frank, Sidhu, Sachdev S.

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Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity von Adams, Jarrett J, Narayanan, Samanthi, Birnbaum, Michael E, Sidhu, Sachdev S, Blevins, Sydney J, Gee, Marvin H, Sibener, Leah V, Baker, Brian M, Kranz, David M, Garcia, K Christopher

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Phage-Based Profiling of Rare Single Cells Using Nanoparticle-Directed Capture von Ma, Yuan, Chen, Kangfu, Xia, Fan, Atwal, Randy, Wang, Hansen, Ahmed, Sharif U, Cardarelli, Lia, Lui, Irene, Duong, Bill, Wang, Zongjie, Wells, James A, Sidhu, Sachdev S, Kelley, Shana O

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A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening von Jeon, Jouhyun, Nim, Satra, Teyra, Joan, Datti, Alessandro, Wrana, Jeffrey L, Sidhu, Sachdev S, Moffat, Jason, Kim, Philip M

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Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site von van Vliet, Vera J E, Huynh, Nhan, Palà, Judith, Patel, Ankoor, Singer, Alex, Slater, Cole, Chung, Jacky, van Huizen, Mariska, Teyra, Joan, Miersch, Shane, Luu, Gia-Khanh, Ye, Wei, Sharma, Nitin, Ganaie, Safder S, Russell, Raquel, Chen, Chao, Maynard, Mindy, Amarasinghe, Gaya K, Mark, Brian L, Kikkert, Marjolein, Sidhu, Sachdev S

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A specificity map for the PDZ domain family von Tonikian, Raffi, Zhang, Yingnan, Sazinsky, Stephen L, Currell, Bridget, Yeh, Jung-Hua, Reva, Boris, Held, Heike A, Appleton, Brent A, Evangelista, Marie, Wu, Yan, Xin, Xiaofeng, Chan, Andrew C, Seshagiri, Somasekar, Lasky, Laurence A, Sander, Chris, Boone, Charles, Bader, Gary D, Sidhu, Sachdev S

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A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis von Ghosh, Eshan, Srivastava, Ashish, Baidya, Mithu, Kumari, Punita, Dwivedi, Hemlata, Nidhi, Kumari, Ranjan, Ravi, Dogra, Shalini, Koide, Akiko, Yadav, Prem N., Sidhu, Sachdev S., Koide, Shohei, Shukla, Arun K.

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A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models von Ling, Binbing, Watt, Kathleen, Banerjee, Sunandan, Newsted, Daniel, Truesdell, Peter, Adams, Jarrett, Sidhu, Sachdev S, Craig, Andrew W B

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Conformational Control of the Ste5 Scaffold Protein Insulates Against MAP Kinase Misactivation von Zalatan, Jesse G., Coyle, Scott M., Rajan, Saravanan, Sidhu, Sachdev S., Lim, Wendell A.

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Crystal Structure of Full-Length KcsA in Its Closed Conformation von Uysal, Serdar, Vásquez, Valeria, Tereshko, Valentina, Esaki, Kaori, Fellouse, Frederic A., Sidhu, Sachdev S., Koide, Shohei, Perozo, Eduardo, Kossiakoff, Anthony, Kuriyan, John

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Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies von Pollock, Samuel B., Hu, Amy, Mou, Yun, Martinko, Alexander J., Julien, Olivier, Hornsby, Michael, Ploder, Lynda, Adams, Jarrett J., Geng, Huimin, Müschen, Markus, Sidhu, Sachdev S., Moffat, Jason, Wells, James A.

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The Intrinsic Contributions of Tyrosine, Serine, Glycine and Arginine to the Affinity and Specificity of Antibodies von Birtalan, Sara, Zhang, Yingnan, Fellouse, Frederic A., Shao, Lihua, Schaefer, Gabriele, Sidhu, Sachdev S.

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A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy von Chidiac, Rony, Abedin, Md, Macleod, Graham, Yang, Andy, Thibeault, Pierre E, Blazer, Levi L, Adams, Jarrett J, Zhang, Lingling, Roehrich, Heidi, Jo, Ha‐Neul, Seshagiri, Somasekar, Sidhu, Sachdev S, Junge, Harald J, Angers, Stephane

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