Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors von Huang, Xiaohua, Cheng, Cliff C., Fischmann, Thierry O., Duca, José S., Richards, Matthew, Tadikonda, Praveen K., Reddy, Panduranga Adulla, Zhao, Lianyun, Arshad Siddiqui, M., Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Shipps, Gerald W.

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Design and synthesis of potent Gram-negative specific LpxC inhibitors von Faruk Mansoor, U., Vitharana, Dilrukshi, Reddy, Panduranga Adulla, Daubaras, Dayna L., McNicholas, Paul, Orth, Peter, Black, Todd, Arshad Siddiqui, M.

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Design, synthesis and SAR of thienopyridines as potent CHK1 inhibitors von Zhao, Lianyun, Zhang, Yingxin, Dai, Chaoyang, Guzi, Timothy, Wiswell, Derek, Seghezzi, Wolfgang, Parry, David, Fischmann, Thierry, Siddiqui, M. Arshad

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Discovery and SAR of hydantoin TACE inhibitors von Yu, Wensheng, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Girijavallabhan, Vinay M., Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Li, Dansu, Lundell, Daniel, Niu, Xiaoda, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Bandarpalle B., Shih, Neng-Yang, Arshad Siddiqui, M., Sun, Jing, Tong, Ling, Umland, Shelby, Wong, Michael K.C., Yang, De-yi, Zhou, Guowei

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Potency switch between CHK1 and MK2: Discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors von Meng, Zhaoyang, Ciavarri, Jeffrey P., McRiner, Andrew, Zhao, Yinyan, Zhao, Lianyun, Reddy, Panduranga Adulla, Zhang, Xingmin, Fischmann, Thierry O., Whitehurst, Charles, Arshad Siddiqui, M.

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Discovery of novel imidazo[1,2- a]pyrazin-8-amines as Brk/PTK6 inhibitors von Zeng, Hongbo, Belanger, David B., Curran, Patrick J., Shipps, Gerald W., Miao, Hua, Bracken, Jack B., Arshad Siddiqui, M., Malkowski, Michael, Wang, Yan

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Pyrazolo[1,5- a]pyrimidine-based inhibitors of HCV polymerase von Popovici-Muller, Janeta, Shipps, Gerald W., Rosner, Kristin E., Deng, Yongqi, Wang, Tong, Curran, Patrick J., Brown, Meredith A., Siddiqui, M. Arshad, Cooper, Alan B., Duca, José, Cable, Michael, Girijavallabhan, Viyyoor

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2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors von Dai, Chaoyang, Li, Dansu, Popovici-Muller, Janeta, Zhao, Lianyun, Girijavallabhan, Vinay M., Rosner, Kristin E., Lavey, Brian J., Rizvi, Razia, Shankar, Bandarpalle B., Wong, Michael K.C., Guo, Zhuyan, Orth, Peter, Strickland, Corey O., Sun, Jing, Niu, Xiaoda, Chen, Shiying, Kozlowski, Joseph A., Lundell, Daniel J., Piwinski, John J., Shih, Neng-Yang, Siddiqui, M. Arshad

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Small Molecule JNK (c-Jun N-Terminal Kinase) Inhibitors von Siddiqui, M. Arshad, Reddy, Panduranga A

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Method for Quantitative Protein−Ligand Affinity Measurements in Compound Mixtures von Annis, D. Allen, Shipps, Gerald W, Deng, Yongqi, Popovici-Müller, Janeta, Siddiqui, M. Arshad, Curran, Patrick J, Gowen, Matthew, Windsor, William T

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Bioisosteric approach to the discovery of imidazo[1,2-a]pyrazines as potent Aurora kinase inhibitors von Meng, Zhaoyang, Kulkarni, Bheemashankar A., Kerekes, Angela D., Mandal, Amit K., Esposite, Sara J., Belanger, David B., Reddy, Panduranga Adulla, Basso, Andrea D., Tevar, Seema, Gray, Kimberly, Jones, Jennifer, Smith, Elizabeth B., Doll, Ronald J., Siddiqui, M. Arshad

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Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors von Belanger, David B., Williams, Michael J., Curran, Patrick J., Mandal, Amit K., Meng, Zhaoyang, Rainka, Matthew P., Yu, Tao, Shih, Neng-Yang, Siddiqui, M. Arshad, Liu, Ming, Tevar, Seema, Lee, Suining, Liang, Lianzhu, Gray, Kimberly, Yaremko, Bohdan, Jones, Jennifer, Smith, Elizabeth B., Prelusky, Dan B., Basso, Andrea D.

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Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase von YONGQI DENG, SHIPPS, Gerald W, TONG WANG, POPOVICI-MULLER, Janeta, ROSNER, Kristin E, ARSHAD SIDDIQUI, M, DUCA, Jose, COOPER, Alan B, CABLE, Michael

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The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors von Rosner, Kristin E., Guo, Zhuyan, Orth, Peter, Shipps, Gerald W., Belanger, David B., Chan, Tin Yau, Curran, Patrick J., Dai, Chaoyang, Deng, Yongqi, Girijavallabhan, Vinay M., Hong, Liwu, Lavey, Brian J., Lee, Joe F., Li, Dansu, Liu, Zhidan, Popovici-Muller, Janeta, Ting, Pauline C., Vaccaro, Henry, Wang, Li, Wang, Tong, Yu, Wensheng, Zhou, Guowei, Niu, Xiaoda, Sun, Jing, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng -Yang, Arshad Siddiqui, M., Strickland, Corey O.

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Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases von Girijavallabhan, Vinay M., Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Firmansjah, Luke, Li, Dansu, Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Kosinski, Aneta, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Banderpalle B., Shih, Neng-Yang, Siddiqui, M. Arshad, Tong, Ling, Wong, Michael K.C., Yang, De-yi, Yang, Liping, Yu, Wensheng, Zhou, Guowei, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Bian, Hong, Lundell, Daniel, Niu, Xiaoda, Shah, Himanshu, Sun, Jing, Umland, Shelby

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Structure and activity relationships of tartrate-based TACE inhibitors von Li, Dansu, Popovici-Muller, Janeta, Belanger, David B., Caldwell, John, Dai, Chaoyang, David, Maria, Girijavallabhan, Vinay M., Lavey, Brian J., Lee, Joe F., Liu, Zhidan, Mazzola, Rob, Rizvi, Razia, Rosner, Kristin E., Shankar, Bandarpalle, Spitler, Jim, Ting, Pauline C., Vaccaro, Henry, Yu, Wensheng, Zhou, Guowei, Zhu, Zhaoning, Niu, Xiaoda, Sun, Jing, Guo, Zhuyan, Orth, Peter, Chen, Shiying, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng-Yang, Shipps, Gerald W., Siddiqui, M. Arshad, Strickland, Corey O.

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Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core von Yu, Tao, Tagat, Jayaram R, Kerekes, Angela D, Doll, Ronald J, Zhang, Yonglian, Xiao, Yushi, Esposite, Sara, Belanger, David B, Curran, Patrick J, Mandal, Amit K, Siddiqui, M. Arshad, Shih, Neng-Yang, Basso, Andrea D, Liu, Ming, Gray, Kimberly, Tevar, Seema, Jones, Jennifer, Lee, Suining, Liang, Lianzhu, Ponery, Samad, Smith, Elizabeth B, Hruza, Alan, Voigt, Johannes, Ramanathan, Lata, Prosise, Winifred, Hu, Mengwei

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Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors von Tong, Ling, Kim, Seong Heon, Rosner, Kristin, Yu, Wensheng, Shankar, Bandarpalle B., Chen, Lei, Li, Dansu, Dai, Chaoyang, Girijavallabhan, Vinay, Popovici-Muller, Janeta, Yang, Liping, Zhou, Guowei, Kosinski, Aneta, Siddiqui, M. Arshad, Shih, Neng-Yang, Guo, Zhuyan, Orth, Peter, Chen, Shiying, Lundell, Daniel, Niu, Xiaoda, Umland, Shelby, Kozlowski, Joseph A.

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Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors von Mansoor, Umar Faruk, Angeles, Angie R., Dai, Chaoyang, Yang, Liping, Vitharana, Dilrukshi, Basso, Andrea D., Gray, Kimberly, Tang, Huadong, Liu, Ming, Liang, Lianzhu, Allbritton, Omaira, Siddiqui, M. Arshad

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Discovery of imidazo[1,2- a]pyrazine-based Aurora kinase inhibitors von Belanger, David B., Curran, Patrick J., Hruza, Alan, Voigt, Johannes, Meng, Zhaoyang, Mandal, Amit K., Siddiqui, M. Arshad, Basso, Andrea D., Gray, Kimberly

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