Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update von Lee, Craig R., Luzum, Jasmine A., Sangkuhl, Katrin, Gammal, Roseann S., Sabatine, Marc S., Stein, Charles Michael, Kisor, David F., Limdi, Nita A., Lee, Yee Ming, Scott, Stuart A., Hulot, Jean‐Sébastien, Roden, Dan M., Gaedigk, Andrea, Caudle, Kelly E., Klein, Teri E., Johnson, Julie A., Shuldiner, Alan R.

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Exome sequencing and analysis of 454,787 UK Biobank participants von Backman, Joshua D., Li, Alexander H., Marcketta, Anthony, Sun, Dylan, Mbatchou, Joelle, Kessler, Michael D., Benner, Christian, Liu, Daren, Locke, Adam E., Balasubramanian, Suganthi, Yadav, Ashish, Banerjee, Nilanjana, Gillies, Christopher E., Damask, Amy, Liu, Simon, Bai, Xiaodong, Hawes, Alicia, Maxwell, Evan, Gurski, Lauren, Watanabe, Kyoko, Kosmicki, Jack A., Rajagopal, Veera, Mighty, Jason, Jones, Marcus, Mitnaul, Lyndon, Stahl, Eli, Coppola, Giovanni, Jorgenson, Eric, Habegger, Lukas, Salerno, William J., Shuldiner, Alan R., Lotta, Luca A., Overton, John D., Cantor, Michael N., Reid, Jeffrey G., Yancopoulos, George, Kang, Hyun M., Marchini, Jonathan, Baras, Aris, Abecasis, Gonçalo R., Ferreira, Manuel A. R.

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Metformin Pharmacogenomics: Current Status and Future Directions von PAWLYK, Aaron C, GIACOMINI, Kathleen M, MCKEON, Catherine, SHULDINER, Alan R, FLOREZ, Jose C

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Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish von Lynch, Megan T, Maloney, Kristin A, Xu, Huichun, Perry, James A, Center, Regeneron Genetics, Shuldiner, Alan R, Mitchell, Braxton D

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Regionally enriched rare deleterious exonic variants in the UK and Ireland von Halachev, Mihail, Gountouna, Viktoria-Eleni, Meynert, Alison, Tzoneva, Gannie, Shuldiner, Alan R., Semple, Colin A., Wilson, James F.

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Analysis of the gut microbiota in the old order Amish and its relation to the metabolic syndrome von Zupancic, Margaret L, Cantarel, Brandi L, Liu, Zhenqiu, Drabek, Elliott F, Ryan, Kathleen A, Cirimotich, Shana, Jones, Cheron, Knight, Rob, Walters, William A, Knights, Daniel, Mongodin, Emmanuel F, Horenstein, Richard B, Mitchell, Braxton D, Steinle, Nanette, Snitker, Soren, Shuldiner, Alan R, Fraser, Claire M

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Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease von Horowitz, Julie E., Warner, Neil, Staples, Jeffrey, Crowley, Eileen, Gosalia, Nehal, Murchie, Ryan, Van Hout, Cristopher, Fiedler, Karoline, Welch, Gabriel, King, Alejandra Klauer, Reid, Jeffrey G., Overton, John D., Baras, Aris, Shuldiner, Alan R., Griffiths, Anne, Gottesman, Omri, Muise, Aleixo M., Gonzaga-Jauregui, Claudia

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Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program von JABLONSKI, Kathleen A, MCATEER, Jarred B, ALTSHULER, David, FLOREZ, Jose C, DE BAKKER, Paul I. W, FRANKS, Paul W, POLLIN, Toni I, HANSON, Robert L, SAXENA, Richa, FOWLER, Sarah, SHULDINER, Alan R, KNOWLER, William C

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Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action von Yang, Rong-Ze, Lee, Mi-Jeong, Hu, Hong, Pray, Jessica, Wu, Hai-Bin, Hansen, Barbara C, Shuldiner, Alan R, Fried, Susan K, McLenithan, John C, Gong, Da-Wei

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Omentin Plasma Levels and Gene Expression Are Decreased in Obesity von DE SOUZA BATISTA, Celia M, YANG, Rong-Ze, FRIED, Susan K, GONG, Da-Wei, SHULDINER, Alan R, POLLIN, Toni I, MCLENITHAN, John C, LEE, Mi-Jeong, GLYNRI, Nicole M, YU, Dao-Zhan, PRAY, Jessica, NDUBUIZU, Kelechi, PATIL, Susheel, SCHWARTZ, Alan, KLIGMAN, Mark

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Missense variants in SORT1 are associated with LDL-C in an Amish population von Mitok, Kelly A, Schueler, Kathryn L, King, Sarah M, Orr, Joseph, Ryan, Kathleen A, Keller, Mark P, Krauss, Ronald M, Mitchell, Braxton D, Shuldiner, Alan R, Attie, Alan D

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Clinical case study meets population cohort: identification of a BRCA1 pathogenic founder variant in Orcadians von Kerr, Shona M, Cowan, Emma, Klaric, Lucija, Bell, Christine, O'Sullivan, Dawn, Buchanan, David, Grzymski, Joseph J, van Hout, Cristopher V, Tzoneva, Gannie, Shuldiner, Alan R, Wilson, James F, Miedzybrodzka, Zosia

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Meta-analysis of genome-wide association data identifies two loci influencing age at menarche von Perry, John R B, Stolk, Lisette, Franceschini, Nora, Lunetta, Kathryn L, Zhai, Guangju, McArdle, Patrick F, Smith, Albert V, Aspelund, Thor, Bandinelli, Stefania, Boerwinkle, Eric, Cherkas, Lynn, Eiriksdottir, Gudny, Estrada, Karol, Ferrucci, Luigi, Folsom, Aaron R, Garcia, Melissa, Gudnason, Vilmundur, Hofman, Albert, Karasik, David, Kiel, Douglas P, Launer, Lenore J, van Meurs, Joyce, Nalls, Michael A, Rivadeneira, Fernando, Shuldiner, Alan R, Singleton, Andrew, Soranzo, Nicole, Tanaka, Toshiko, Visser, Jenny A, Weedon, Michael N, Wilson, Scott G, Zhuang, Vivian, Streeten, Elizabeth A, Harris, Tamara B, Murray, Anna, Spector, Tim D, Demerath, Ellen W, Uitterlinden, André G, Murabito, Joanne M

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The relation between CYP2C19 genotype and phenotype in stented patients on maintenance dual antiplatelet therapy von Gurbel, Paul A., MD, Shuldiner, Alan R., MD, Bliden, Kevin P., BS, Ryan, Kathaleen, MPH, Pakyz, Ruth E., BS, Tantry, Udaya S., PhD

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Whole-genome association study identifies STK39 as a hypertension susceptibility gene von Wang, Ying, O'Connell, Jeffrey R, McArdle, Patrick F, Wade, James B, Dorff, Sarah E, Shah, Sanjiv J, Shi, Xiaolian, Pan, Lin, Rampersaud, Evadnie, Shen, Haiqing, Kim, James D, Subramanya, Arohan R, Steinle, Nanette I, Parsa, Afshin, Ober, Carole C, Welling, Paul A, Chakravarti, Aravinda, Weder, Alan B, Cooper, Richard S, Mitchell, Braxton D, Shuldiner, Alan R, Chang, Yen-Pei C

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Telomere length is paternally inherited and is associated with parental lifespan von Njajou, Omer T, Cawthon, Richard M, Damcott, Coleen M, Wu, Shih-Hsuan, Ott, Sandy, Garant, Michael J, Blackburn, Elizabeth H, Mitchell, Braxton D, Shuldiner, Alan R, Hsueh, Wen-Chi

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Genomic diagnostics within a medically underserved population: efficacy and implications von Strauss, Kevin A., Gonzaga-Jauregui, Claudia, Brigatti, Karlla W., Williams, Katie B., King, Alejandra K., Van Hout, Cristopher, Robinson, Donna L., Young, Millie, Praveen, Kavita, Heaps, Adam D., Kuebler, Mindy, Baras, Aris, Reid, Jeffrey G., Overton, John D., Dewey, Frederick E., Jinks, Robert N., Finnegan, Ian, Mellis, Scott J., Shuldiner, Alan R., Puffenberger, Erik G.

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Lipoprotein genotype and conserved pathway for exceptional longevity in humans von Atzmon, Gil, Rincon, Marielisa, Schechter, Clyde B, Shuldiner, Alan R, Lipton, Richard B, Bergman, Aviv, Barzilai, Nir

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Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications von Yang, Rong-Ze, Lee, Mi-Jeong, Hu, Hong, Pollin, Toni I, Ryan, Alice S, Nicklas, Barbara J, Snitker, Soren, Horenstein, Richard B, Hull, Kristen, Goldberg, Nelson H, Goldberg, Andrew P, Shuldiner, Alan R, Fried, Susan K, Gong, Da-Wei

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Randomized evaluation of the loss‐of‐function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics von Lewis, Joshua P., Ryan, Kathleen A., Streeten, Elizabeth A., Whitlatch, Hilary B., Daue, Melanie, Tanner, Keith, Perry, James A., O'Connell, Jeffrey R., Shuldiner, Alan R., Mitchell, Braxton D.

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