Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design von Ostrem, Jonathan M. L., Shokat, Kevan M.

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The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling von Dar, Arvin C, Shokat, Kevan M

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Drugging MYCN through an Allosteric Transition in Aurora Kinase A von Gustafson, William Clay, Meyerowitz, Justin Gabriel, Nekritz, Erin A., Chen, Justin, Benes, Cyril, Charron, Elise, Simonds, Erin F., Seeger, Robert, Matthay, Katherine K., Hertz, Nicholas T., Eilers, Martin, Shokat, Kevan M., Weiss, William A.

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions von Ostrem, Jonathan M., Peters, Ulf, Sos, Martin L., Wells, James A., Shokat, Kevan M.

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Targeting the cancer kinome through polypharmacology von Knight, Zachary A, Shokat, Kevan M, Lin, Henry

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A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1 von Hertz, Nicholas T., Berthet, Amandine, Sos, Martin L., Thorn, Kurt S., Burlingame, Al L., Nakamura, Ken, Shokat, Kevan M.

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Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A von White, Kris M, Rosales, Romel, Yildiz, Soner, Kehrer, Thomas, Miorin, Lisa, Moreno, Elena, Jangra, Sonia, Uccellini, Melissa B, Rathnasinghe, Raveen, Coughlan, Lynda, Martinez-Romero, Carles, Batra, Jyoti, Rojc, Ajda, Bouhaddou, Mehdi, Fabius, Jacqueline M, Obernier, Kirsten, Dejosez, Marion, Guillén, María José, Losada, Alejandro, Avilés, Pablo, Schotsaert, Michael, Zwaka, Thomas, Vignuzzi, Marco, Shokat, Kevan M, Krogan, Nevan J, García-Sastre, Adolfo

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Chemical genetic discovery of targets and anti-targets for cancer polypharmacology von Dar, Arvin C., Das, Tirtha K., Shokat, Kevan M., Cagan, Ross L.

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Evolutionarily divergent mTOR remodels translatome for tissue regeneration von Zhulyn, Olena, Rosenblatt, Hannah D., Shokat, Leila, Dai, Shizhong, Kuzuoglu-Öztürk, Duygu, Zhang, Zijian, Ruggero, Davide, Shokat, Kevan M., Barna, Maria

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EGFR Phosphorylates Tumor-Derived EGFRvIII Driving STAT3/5 and Progression in Glioblastoma von Fan, Qi-Wen, Cheng, Christine K., Gustafson, W. Clay, Charron, Elizabeth, Zipper, Petra, Wong, Robyn A., Chen, Justin, Lau, Jasmine, Knobbe-Thomsen, Christiane, Weller, Michael, Jura, Natalia, Reifenberger, Guido, Shokat, Kevan M., Weiss, William A.

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Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 von Tummino, Tia A, Rezelj, Veronica V, Fischer, Benoit, Fischer, Audrey, O'Meara, Matthew J, Monel, Blandine, Vallet, Thomas, White, Kris M, Zhang, Ziyang, Alon, Assaf, Schadt, Heiko, O'Donnell, Henry R, Lyu, Jiankun, Rosales, Romel, McGovern, Briana L, Rathnasinghe, Raveen, Jangra, Sonia, Schotsaert, Michael, Galarneau, Jean-René, Krogan, Nevan J, Urban, Laszlo, Shokat, Kevan M, Kruse, Andrew C, García-Sastre, Adolfo, Schwartz, Olivier, Moretti, Francesca, Vignuzzi, Marco, Pognan, Francois, Shoichet, Brian K

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Site-specific incorporation of phosphotyrosine using an expanded genetic code von Hoppmann, Christian, Wong, Allison, Yang, Bing, Li, Shuwei, Hunter, Tony, Shokat, Kevan M, Wang, Lei

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2 von Feldman, Morris E, Apsel, Beth, Uotila, Aino, Loewith, Robbie, Knight, Zachary A, Ruggero, Davide, Shokat, Kevan M

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A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression von Schachter, Miriam Merzel, Merrick, Karl A., Larochelle, Stéphane, Hirschi, Alexander, Zhang, Chao, Shokat, Kevan M., Rubin, Seth M., Fisher, Robert P.

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Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis von Banko, Max R., Allen, Jasmina J., Schaffer, Bethany E., Wilker, Erik W., Tsou, Peiling, White, Jamie L., Villén, Judit, Wang, Beatrice, Kim, Sara R., Sakamoto, Kei, Gygi, Steven P., Cantley, Lewis C., Yaffe, Michael B., Shokat, Kevan M., Brunet, Anne

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Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction von Schaffer, Bethany E., Levin, Rebecca S., Hertz, Nicholas T., Maures, Travis J., Schoof, Michael L., Hollstein, Pablo E., Benayoun, Bérénice A., Banko, Max R., Shaw, Reuben J., Shokat, Kevan M., Brunet, Anne

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Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II von Larochelle, Stéphane, Amat, Ramon, Glover-Cutter, Kira, Sansó, Miriam, Zhang, Chao, Allen, Jasmina J, Shokat, Kevan M, Bentley, David L, Fisher, Robert P

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Expanding the Scope of Electrophiles Capable of Targeting K‑Ras Oncogenes von McGregor, Lynn M, Jenkins, Meredith L, Kerwin, Caitlin, Burke, John E, Shokat, Kevan M

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Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1 von Lazarus, Michael B., Shokat, Kevan M.

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Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers von Pourdehnad, Michael, Truitt, Morgan L., Siddiqi, Imran N., Ducker, Gregory S., Shokat, Kevan M., Ruggero, Davide

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