Drugging the 'undruggable' cancer targets von Dang, Chi V., Reddy, E. Premkumar, Shokat, Kevan M., Soucek, Laura

Volltext

Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S) von Zhang, Ziyang, Guiley, Keelan Z., Shokat, Kevan M.

Volltext

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design von Ostrem, Jonathan M. L., Shokat, Kevan M.

Volltext

Drugging MYCN through an Allosteric Transition in Aurora Kinase A von Gustafson, William Clay, Meyerowitz, Justin Gabriel, Nekritz, Erin A., Chen, Justin, Benes, Cyril, Charron, Elise, Simonds, Erin F., Seeger, Robert, Matthay, Katherine K., Hertz, Nicholas T., Eilers, Martin, Shokat, Kevan M., Weiss, William A.

Volltext

Bifunctional Small‐Molecule Ligands of K‐Ras Induce Its Association with Immunophilin Proteins von Zhang, Ziyang, Shokat, Kevan M.

Volltext

The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling von Dar, Arvin C, Shokat, Kevan M

Volltext

A Neo-Substrate that Amplifies Catalytic Activity of Parkinson’s-Disease-Related Kinase PINK1 von Hertz, Nicholas T., Berthet, Amandine, Sos, Martin L., Thorn, Kurt S., Burlingame, Al L., Nakamura, Ken, Shokat, Kevan M.

Volltext

Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP von Hu, Qi, Shokat, Kevan M.

Volltext

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions von Ostrem, Jonathan M., Peters, Ulf, Sos, Martin L., Wells, James A., Shokat, Kevan M.

Volltext

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2 von Feldman, Morris E, Apsel, Beth, Uotila, Aino, Loewith, Robbie, Knight, Zachary A, Ruggero, Davide, Shokat, Kevan M

Volltext

Targeting the cancer kinome through polypharmacology von Knight, Zachary A, Shokat, Kevan M, Lin, Henry

Volltext

Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D von Zheng, Qinheng, Zhang, Ziyang, Guiley, Keelan Z., Shokat, Kevan M.

Volltext

A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability von Guiley, Keelan Z, Shokat, Kevan M

Volltext

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF von Shokat, Kevan M, Rosen, Neal, Zhang, Chao, Bollag, Gideon, Poulikakos, Poulikos I

Volltext

Evolutionarily divergent mTOR remodels translatome for tissue regeneration von Zhulyn, Olena, Rosenblatt, Hannah D., Shokat, Leila, Dai, Shizhong, Kuzuoglu-Öztürk, Duygu, Zhang, Zijian, Ruggero, Davide, Shokat, Kevan M., Barna, Maria

Volltext

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A von White, Kris M, Rosales, Romel, Yildiz, Soner, Kehrer, Thomas, Miorin, Lisa, Moreno, Elena, Jangra, Sonia, Uccellini, Melissa B, Rathnasinghe, Raveen, Coughlan, Lynda, Martinez-Romero, Carles, Batra, Jyoti, Rojc, Ajda, Bouhaddou, Mehdi, Fabius, Jacqueline M, Obernier, Kirsten, Dejosez, Marion, Guillén, María José, Losada, Alejandro, Avilés, Pablo, Schotsaert, Michael, Zwaka, Thomas, Vignuzzi, Marco, Shokat, Kevan M, Krogan, Nevan J, García-Sastre, Adolfo

Volltext

Chemoselective Covalent Modification of K‑Ras(G12R) with a Small Molecule Electrophile von Zhang, Ziyang, Morstein, Johannes, Ecker, Andrew K., Guiley, Keelan Z., Shokat, Kevan M.

Volltext

Brain-restricted mTOR inhibition with binary pharmacology von Zhang, Ziyang, Fan, Qiwen, Luo, Xujun, Lou, Kevin, Weiss, William A., Shokat, Kevan M.

Volltext

EGFR Phosphorylates Tumor-Derived EGFRvIII Driving STAT3/5 and Progression in Glioblastoma von Fan, Qi-Wen, Cheng, Christine K., Gustafson, W. Clay, Charron, Elizabeth, Zipper, Petra, Wong, Robyn A., Chen, Justin, Lau, Jasmine, Knobbe-Thomsen, Christiane, Weller, Michael, Jura, Natalia, Reifenberger, Guido, Shokat, Kevan M., Weiss, William A.

Volltext

A Cdk7-Cdk4 T-Loop Phosphorylation Cascade Promotes G1 Progression von Schachter, Miriam Merzel, Merrick, Karl A., Larochelle, Stéphane, Hirschi, Alexander, Zhang, Chao, Shokat, Kevan M., Rubin, Seth M., Fisher, Robert P.

Volltext