Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors von Woodhead, Jeffrey L, Brock, William J, Roth, Sharin E, Shoaf, Susan E, Brouwer, Kim L R, Church, Rachel, Grammatopoulos, Tom N, Stiles, Linsey, Siler, Scott Q, Howell, Brett A, Mosedale, Merrie, Watkins, Paul B, Shoda, Lisl K M

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The role of quantitative systems pharmacology modeling in the prediction and explanation of idiosyncratic drug-induced liver injury von Woodhead, Jeffrey L., Watkins, Paul B., Howell, Brett A., Siler, Scott Q., Shoda, Lisl K.M.

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A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation von Shoda, Lisl K.M., Young, Daniel L., Ramanujan, Saroja, Whiting, Chan C., Atkinson, Mark A., Bluestone, Jeffrey A., Eisenbarth, George S., Mathis, Diane, Rossini, Aldo A., Campbell, Scott E., Kahn, Richard, Kreuwel, Huub T.C.

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Preexisting Autoantibodies Predict Efficacy of Oral Insulin to Cure Autoimmune Diabetes in Combination With Anti-CD3 von MAMCHAK, Alusha A, MANENKOVA, Yulia, LECONET, Wilhem, YANAN ZHENG, CHAN, Jason R, STOKES, Cynthia L, SHODA, Lisl K. M, VON HERRATH, Matthias, BRESSON, Damien

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Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches von Bhattacharya, Sudin, Shoda, Lisl K M, Zhang, Qiang, Woods, Courtney G, Howell, Brett A, Siler, Scott Q, Woodhead, Jeffrey L, Yang, Yuching, McMullen, Patrick, Watkins, Paul B, Andersen, Melvin E

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Quantitative Systems Toxicology Identifies Independent Mechanisms for Hepatotoxicity and Bilirubin Elevations Due to AKR1C3 Inhibitor BAY1128688 von Battista, Christina, Shoda, Lisl K.M., Watkins, Paul B., Groettrup‐Wolfers, Esther, Rottmann, Antje, Raschke, Marian, Generaux, Grant T.

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Assessing Effects of BHV-0223 40 mg Zydis Sublingual Formulation and Riluzole 50 mg Oral Tablet on Liver Function Test Parameters Utilizing DILIsym von Longo, Diane M, Shoda, Lisl K M, Howell, Brett A, Coric, Vladimir, Berman, Robert M, Qureshi, Irfan A

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The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanist... von Beaudoin, James J, Clemens, Lara, Miedel, Mark T, Gough, Albert, Zaidi, Fatima, Ramamoorthy, Priya, Wong, Kari E, Sarangarajan, Rangaprasad, Battista, Christina, Shoda, Lisl K M, Siler, Scott Q, Taylor, D Lansing, Howell, Brett A, Vernetti, Lawrence A, Yang, Kyunghee

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Modulation of host immune responses by protozoal DNA von Brown, Wendy C, Suarez, Carlos E, Shoda, Lisl K.M, Estes, D.Mark

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Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury von Shoda, Lisl K. M., Woodhead, Jeffrey L., Siler, Scott Q., Watkins, Paul B., Howell, Brett A.

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Induction of interleukin-6 and interleukin-12 in bovine B lymphocytes, monocytes, and macrophages by a CpG oligodeoxynucleotide (ODN 2059) containing the GTCGTT motif von Zhang, Y, Shoda, L K, Brayton, K A, Estes, D M, Palmer, G H, Brown, W C

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Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses von Shoda, Lisl KM, Battista, Christina, Siler, Scott Q, Pisetsky, David S, Watkins, Paul B, Howell, Brett A

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Quantitative systems toxicology (QST) reproduces species differences in PF‐04895162 liver safety due to combined mitochondrial and bile acid toxicity von Generaux, Grant, Lakhani, Vinal V., Yang, Yuching, Nadanaciva, Sashi, Qiu, Luping, Riccardi, Keith, Di, Li, Howell, Brett A., Siler, Scott Q., Watkins, Paul B., Barton, Hugh A., Aleo, Michael D., Shoda, Lisl K. M.

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The virtual NOD mouse: applying predictive biosimulation to research in type 1 diabetes von Zheng, Yanan, Kreuwel, Huub T C, Young, Daniel L, Shoda, Lisl K M, Ramanujan, Saroja, Gadkar, Kapil G, Atkinson, Mark A, Whiting, Chan C

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Dosing and timing effects of anti-CD40L therapy: predictions from a mathematical model of type 1 diabetes von Gadkar, Kapil G, Shoda, Lisl K M, Kreuwel, Huub T C, Ramanujan, Saroja, Zheng, Yanan, Whiting, Chan C, Young, Daniel L

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Immunostimulatory CpG-modified plasmid DNA enhances IL-12, TNF-α, and NO production by bovine macrophages von Shoda, Lisl K. M., Kegerreis, Kimberly A., Suarez, Carlos E., Mwangi, Waithaka, Knowles, Donald P., Brown, Wendy C.

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Mechanisms mediating anti-CD3 antibody efficacy: insights from a mathematical model of type 1 diabetes von Young, Daniel L, Ramanujan, Saroja, Kreuwel, Huub T C, Whiting, Chan Chung, Gadkar, Kapil G, Shoda, Lisl K M

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Stimulation of Nitric Oxide Production in Macrophages by Babesia bovis von STICH, R. W, SHODA, L. K. M, DREEWES, M, ADLER, B, JUNGI, T. W, BROWN, W. C

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Mechanisms Mediating Anti-CD3 Antibody Efficacy von YOUNG, DANIEL L., RAMANUJAN, SAROJA, KREUWEL, HUUB T.C., WHITING, CHAN CHUNG, GADKAR, KAPIL G., SHODA, LISL K.M.

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Cloning of a cDNA encoding bovine interleukin-18 and analysis of IL-18 expression in macrophages and its IFN-gamma-inducing activity von Shoda, L K, Zarlenga, D S, Hirano, A, Brown, W C

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