Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming von Barile, Elisa, Baggio, Carlo, Gambini, Luca, Shiryaev, Sergey A., Strongin, Alex Y., Pellecchia, Maurizio

Volltext

High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome von Shiryaev, Sergey A, Chernov, Andrei V, Golubkov, Vladislav S, Thomsen, Elliot R, Chudin, Eugene, Chee, Mark S, Kozlov, Igor A, Strongin, Alex Y, Cieplak, Piotr

Volltext

Immunodominant fragments of myelin basic protein initiate T cell-dependent pain von Liu, Huaqing, Shiryaev, Sergey A, Chernov, Andrei V, Kim, Youngsoon, Shubayev, Igor, Remacle, Albert G, Baranovskaya, Svetlana, Golubkov, Vladislav S, Strongin, Alex Y, Shubayev, Veronica I

Volltext

Tissue Inhibitor of Metalloproteinases-2 Binding to Membrane-type 1 Matrix Metalloproteinase Induces MAPK Activation and Cell Growth by a Non-proteolytic Mechanism von D'Alessio, Silvia, Ferrari, Giovanni, Cinnante, Karma, Scheerer, William, Galloway, Aubrey C., Roses, Daniel F., Rozanov, Dmitri V., Remacle, Albert G., Oh, Eok-Soo, Shiryaev, Sergey A., Strongin, Alex Y., Pintucci, Giuseppe, Mignatti, Paolo

Volltext

Probing of exosites leads to novel inhibitor scaffolds of HCV NS3/4A proteinase von Shiryaev, Sergey A, Cheltsov, Anton V, Strongin, Alex Y

Volltext

Targeting Host Cell Furin Proprotein Convertases as a Therapeutic Strategy against Bacterial Toxins and Viral Pathogens von Shiryaev, Sergey A., Remacle, Albert G., Ratnikov, Boris I., Nelson, Nicholas A., Savinov, Alexei Y., Wei, Ge, Bottini, Massimo, Rega, Michele F., Parent, Amelie, Desjardins, Roxane, Fugere, Martin, Day, Robert, Sabet, Mojgan, Pellecchia, Maurizio, Liddington, Robert C., Smith, Jeffrey W., Mustelin, Tomas, Guiney, Donald G., Lebl, Michal, Strongin, Alex Y.

Volltext

Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase von Shiryaev, Sergey A, Ratnikov, Boris I, Chekanov, Alexei V, Sikora, Sergey, Rozanov, Dmitri V, Godzik, Adam, Wang, Jun, Smith, Jeffrey W, Huang, Ziwei, Lindberg, Iris, Samuel, Melanie A, Diamond, Michael S, Strongin, Alex Y

Volltext

Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site von Gawlik, Katarzyna, Shiryaev, Sergey A, Zhu, Wenhong, Motamedchaboki, Khatereh, Desjardins, Roxane, Day, Robert, Remacle, Albert G, Stec, Boguslaw, Strongin, Alex Y

Volltext

Dynamic Interdomain Interactions Contribute to the Inhibition of Matrix Metalloproteinases by Tissue Inhibitors of Metalloproteinases von Remacle, Albert G., Shiryaev, Sergey A., Radichev, Ilian A., Rozanov, Dmitri V., Stec, Boguslaw, Strongin, Alex Y.

Volltext

Switching the Substrate Specificity of the Two-Component NS2B-NS3 Flavivirus Proteinase by Structure-Based Mutagenesis von SHIRYAEV, Sergey A, RATNIKOV, Boris I, ALESHIN, Alexander E, KOZLOV, Igor A, NELSON, Nicholas A, LEBL, Michal, SMITH, Jeffrey W, LIDDINGTON, Robert C, STRONGIN, Alex Y

Volltext

Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth von REMACLE, Albert G, GOLUBKOV, Vladislav S, SHIRYAEV, Sergey A, DAHL, Russell, STEBBINS, John L, CHERNOV, Andrei V, CHELTSOV, Anton V, PELLECCHIA, Maurizio, STRONGIN, Alex Y

Volltext

Selective function-blocking monoclonal human antibody highlights the important role of membrane type-1 matrix metalloproteinase (MT1-MMP) in metastasis von Remacle, Albert G, Cieplak, Piotr, Nam, Dong Hyun, Shiryaev, Sergey A, Ge, Xin, Strongin, Alex Y

Volltext

Simultaneous Visualization of Protumorigenic Src and MT1-MMP Activities with Fluorescence Resonance Energy Transfer von MINGXING OUYANG, HE HUANG, SHANER, Nathan C, REMACLE, Albert G, SHIRYAEV, Sergey A, STRONGIN, Alex Y, TSIEN, Roger Y, YINGXIAO WANG

Volltext

NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus von Shiryaev, Sergey A, Chernov, Andrei V, Aleshin, Alexander E, Shiryaeva, Tatiana N, Strongin, Alex Y

Volltext

Substrate Cleavage Profiling Suggests a Distinct Function of Bacteroides fragilis Metalloproteinases (Fragilysin and Metalloproteinase II) at the Microbiome-Inflammation-Cancer Int... von Shiryaev, Sergey A., Remacle, Albert G., Chernov, Andrei V., Golubkov, Vladislav S., Motamedchaboki, Khatereh, Muranaka, Norihito, Dambacher, Corey M., Capek, Petr, Kukreja, Muskan, Kozlov, Igor A., Perucho, Manuel, Cieplak, Piotr, Strongin, Alex Y.

Volltext

Partial Jacobsen syndrome phenotype in a patient with a de novo frameshift mutation in the ETS1 transcription factor von Tootleman, Eva, Malamut, Barbara, Akshoomoff, Natacha, Mattson, Sarah N, Hoffman, Hal M, Jones, Marilyn C, Printz, Beth, Shiryaev, Sergey A, Grossfeld, Paul

Volltext

Author Correction: Blocking Zika virus vertical transmission von Mesci, Pinar, Macia, Angela, Moore, Spencer M., Shiryaev, Sergey A., Pinto, Antonella, Huang, Chun-Teng, Tejwani, Leon, Fernandes, Isabella R., Suarez, Nicole A., Kolar, Matthew J., Montefusco, Sandro, Rosenberg, Scott C., Herai, Roberto H., Cugola, Fernanda R., Russo, Fabiele B., Sheets, Nicholas, Saghatelian, Alan, Shresta, Sujan, Momper, Jeremiah D., Siqueira-Neto, Jair L., Corbett, Kevin D., Beltrão-Braga, Patricia C. B., Terskikh, Alexey V., Muotri, Alysson R.

Volltext

ATPase activity of a yeast secretory glycoprotein allows ER exit during inactivation of COPII components Sec24p and Sec13p von Suntio, Taina, Shiryaev, Sergey A, Makarow, Marja

Volltext

Biochemical Characterization of the Cellular Glycosylphosphatidylinositol-linked Membrane Type-6 Matrix Metalloproteinase von Radichev, Ilian A., Remacle, Albert G., Shiryaev, Sergey A., Purves, Angela N., Johnson, Sherida L., Pellecchia, Maurizio, Strongin, Alex Y.

Volltext

Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase von Shiryaev, Sergey A, Cheltsov, Anton V, Gawlik, Katarzyna, Ratnikov, Boris I, Strongin, Alex Y

Volltext