Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity von Lan, Hong, Cheng, Cliff C., Kowalski, Timothy J., Pang, Ling, Shan, Lixin, Chuang, Cheng-Chi, Jackson, James, Rojas-Triana, Alberto, Bober, Loretta, Liu, Li, Voigt, Johannes, Orth, Peter, Yang, Xianshu, Shipps, Jr. Gerald W., Hedrick, Joseph A.

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Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors von Huang, Xiaohua, Cheng, Cliff C., Fischmann, Thierry O., Duca, José S., Richards, Matthew, Tadikonda, Praveen K., Reddy, Panduranga Adulla, Zhao, Lianyun, Arshad Siddiqui, M., Parry, David, Davis, Nicole, Seghezzi, Wolfgang, Wiswell, Derek, Shipps, Gerald W.

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Discovery of novel imidazo[1,2- a]pyrazin-8-amines as Brk/PTK6 inhibitors von Zeng, Hongbo, Belanger, David B., Curran, Patrick J., Shipps, Gerald W., Miao, Hua, Bracken, Jack B., Arshad Siddiqui, M., Malkowski, Michael, Wang, Yan

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Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1) von Deng, Yongqi, Yang, Zhiwei, Shipps, Gerald W., Lo, Sie-Mun, West, Robert, Hwa, Joyce, Zheng, Shuqin, Farley, Constance, Lachowicz, Jean, van Heek, Margaret, Bass, Alan S., Sinha, Dinesh P., Mahon, Craig R., Cartwright, Mark E.

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Discovery and optimization of antibacterial AccC inhibitors von Cheng, Cliff C., Shipps, Gerald W., Yang, Zhiwei, Sun, Binyuan, Kawahata, Noriyuki, Soucy, Kyle A., Soriano, Aileen, Orth, Peter, Xiao, Li, Mann, Paul, Black, Todd

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Discovery and Characterization of Orthosteric and Allosteric Muscarinic M2 Acetylcholine Receptor Ligands by Affinity Selection–Mass Spectrometry von Whitehurst, Charles E., Nazef, Naim, Annis, D. Allen, Hou, Yongmin, Murphy, Denise M., Spacciapoli, Peter, Yao, Zhiping, Ziebell, Michael R., Cheng, Cliff C., Shipps, Jr, Gerald W., Felsch, Jason S., Lau, David, Nash, Huw M.

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Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase von Deng, Yongqi, Shipps, Gerald W, Cooper, Alan, English, Jessie M, Annis, D. Allen, Carr, Donna, Nan, Yang, Wang, Tong, Zhu, Hugh Y, Chuang, Cheng-Chi, Dayananth, Priya, Hruza, Alan W, Xiao, Li, Jin, Weihong, Kirschmeier, Paul, Windsor, William T, Samatar, Ahmed A

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Substituted piperidines as HDM2 inhibitors von Ma, Yao, Lahue, Brian R, Shipps, Jr, Gerald W, Brookes, Jeseca, Wang, Yaolin

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MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology von Boga, Sobhana Babu, Deng, Yongqi, Zhu, Liang, Nan, Yang, Cooper, Alan B., Shipps, Gerald W., Doll, Ronald, Shih, Neng-Yang, Zhu, Hugh, Sun, Robert, Wang, Tong, Paliwal, Sunil, Tsui, Hon-Chung, Gao, Xiaolei, Yao, Xin, Desai, Jagdish, Wang, James, Alhassan, Abdul Basit, Kelly, Joseph, Patel, Mehul, Muppalla, Kiran, Gudipati, Subrahmanyam, Zhang, Li-Kang, Buevich, Alexei, Hesk, David, Carr, Donna, Dayananth, Priya, Black, Stuart, Mei, Hong, Cox, Kathleen, Sherborne, Bradley, Hruza, Alan W., Xiao, Li, Jin, Weihong, Long, Brian, Liu, Gongjie, Taylor, Stacey A., Kirschmeier, Paul, Windsor, William T., Bishop, Robert, Samatar, Ahmed A.

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Structure–activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53–hDM2 inhibitors von Tian, Yuan, Ma, Yao, Gibeau, Craig R., Lahue, Brian R., Shipps, Gerald W., Strickland, Corey, Bogen, Stéphane L.

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Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction von Pan, Weidong, Lahue, Brian R, Ma, Yao, Nair, Latha G, Shipps, Jr, Gerald W, Wang, Yaolin, Doll, Ronald, Bogen, Stéphane L

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Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor von Deng, Yongqi, Shipps, Jr, Gerald W, Zhao, Lianyun, Siddiqui, M Arshad, Popovici-Muller, Janeta, Curran, Patrick J, Duca, Jose S, Hruza, Alan W, Fischmann, Thierry O, Madison, Vincent S, Zhang, Rumin, McNemar, Charles W, Mayhood, Todd W, Syto, Rosalinda, Annis, Allen, Kirschmeier, Paul, Lees, Emma M, Parry, David A, Windsor, William T

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Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain von Sheth, Payal R, Shipps, Gerald W, Seghezzi, Wolfgang, Smith, Catherine K, Chuang, Cheng-Chi, Sanden, David, Basso, Andrea D, Vilenchik, Lev, Gray, Kimberly, Annis, D. Allen, Nickbarg, Elliott, Ma, Yao, Lahue, Brian, Herbst, Ronald, Le, Hung V

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Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode von Huang, Xiaohua, Cheng, Cliff C, Fischmann, Thierry O, Duca, José S, Yang, Xianshu, Richards, Matthew, Shipps, Gerald W

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Substituted benzimidazoles: A novel chemotype for small molecule hKSP inhibitors von Lahue, Brian R., Ma, Yao, Shipps, Gerald W., Seghezzi, Wolfgang, Herbst, Ronald

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Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors von Bogen, Stéphane L, Pan, Weidong, Gibeau, Craig R, Lahue, Brian R, Ma, Yao, Nair, Latha G, Seigel, Elise, Shipps, Gerald W, Tian, Yuan, Wang, Yaolin, Lin, Yinghui, Liu, Ming, Liu, Suxing, Mirza, Asra, Wang, Xiaoying, Lipari, Philip, Seidel-Dugan, Cynthia, Hicklin, Daniel J, Bishop, W. Robert, Rindgen, Diane, Nomeir, Amin, Prosise, Winifred, Reichert, Paul, Scapin, Giovanna, Strickland, Corey, Doll, Ronald J

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Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor von Ma, Yao, Lahue, Brian R, Gibeau, Craig R, Shipps, Gerald W, Bogen, Stéphane L, Wang, Yaolin, Guo, Zhuyan, Guzi, Timothy J

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Pyrazolo[1,5- a]pyrimidine-based inhibitors of HCV polymerase von Popovici-Muller, Janeta, Shipps, Gerald W., Rosner, Kristin E., Deng, Yongqi, Wang, Tong, Curran, Patrick J., Brown, Meredith A., Siddiqui, M. Arshad, Cooper, Alan B., Duca, José, Cable, Michael, Girijavallabhan, Viyyoor

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Inhibitors of hepatitis C virus polymerase: Synthesis and characterization of novel 2-oxy-6-fluoro- N-(( S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides von Cheng, Cliff C., Shipps, Gerald W., Yang, Zhiwei, Kawahata, Noriyuki, Lesburg, Charles A., Duca, José S., Bandouveres, Jamie, Bracken, Jack D., Jiang, Chuan-kui, Agrawal, Sony, Ferrari, Eric, Huang, H.-C.

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Method for Quantitative Protein−Ligand Affinity Measurements in Compound Mixtures von Annis, D. Allen, Shipps, Gerald W, Deng, Yongqi, Popovici-Müller, Janeta, Siddiqui, M. Arshad, Curran, Patrick J, Gowen, Matthew, Windsor, William T

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