Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress von Ri, M, Iida, S, Nakashima, T, Miyazaki, H, Mori, F, Ito, A, Inagaki, A, Kusumoto, S, Ishida, T, Komatsu, H, Shiotsu, Y, Ueda, R

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Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing von Ri, M, Tashiro, E, Oikawa, D, Shinjo, S, Tokuda, M, Yokouchi, Y, Narita, T, Masaki, A, Ito, A, Ding, J, Kusumoto, S, Ishida, T, Komatsu, H, Shiotsu, Y, Ueda, R, Iwawaki, T, Imoto, M, Iida, S

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Thin-Film π-Type Micro TEG Using Vacuum/Insulator-Hybrid Isolation with Convex-Shape Hot-Plate Module Structure for Wearable Device Applications von Shiotsu, Y, Seino, T, Chiwaki, N, Sugahara, S

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Circulating cell-free DNA molecular profiling among east Asian patients reveals activating MET alterations are common in diverse advanced cancer types von Ikeda, S., Kumaki, Y., Rich, T.A., Shiotsu, Y., Franovic, A., Raymond, V.M., Kurzrock, R., Lanman, R.B., Lee, J., Mok, T.S.K.

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RET rearrangements may arise following anti-EGFR therapy in advanced colorectal cancer von Rich, T A, Clifton, K, Grothey, A, Hendifar, A, Henry, D H, Kagawa, Y, Nakamura, Y, Okamoto, W, Tan, B R, Sherrill, G, Yoshino, T, Raymond, V M, Shiotsu, Y, Lanman, R B, Morris, V

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Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1 Noxa axis von Kojima, K, Konopleva, M, Tsao, T, Andreeff, M, Ishida, H, Shiotsu, Y, Jin, L, Tabe, Y, Nakakuma, H

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Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib von Ishii, T, Seike, T, Nakashima, T, Juliger, S, Maharaj, L, Soga, S, Akinaga, S, Cavenagh, J, Joel, S, Shiotsu, Y

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MO60-3 Aggregated analysis of integrated whole exome (WES) and whole transcriptome (WTS) sequencing in 1,000 cancer patients von Chernyshov, K., Love, A., Rumyantsev, K., Senichkin, V., Sagaradze, G., Polyakova, Z., Shiotsu, Y., Clayton, P., Postovalova, E., Kotlov, N., Ogloblina, A., Bagaev, A., Fowler, N.

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373PCell-free DNA (cfDNA) landscape in ERBB2 (HER2)-amplified Asian cancer patient population von Lee, J, Franovic, A, Rich, T A, Shiotsu, Y, Raymond, V M, Lanman, R B

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Stereospecific antitumor activity of radicicol oxime derivatives von SOGA, Shiro, SHARMA, Sreenath V, SCHULTE, Theodor W, NECKERS, Leonard M, AKINAGA, Shiro, SHIOTSU, Yukimasa, SHIMIZU, Makiko, TAHARA, Harunobu, YAMAGUCHI, Kazuo, IKUINA, Yoji, MURAKATA, Chikara, TAMAOKI, Tatsuya, KUREBAYASHI, Junichi

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378PCirculating cell-free DNA molecular profiling among east Asian patients reveals activating MET alterations are common in diverse advanced cancer types von Ikeda, S, Kumaki, Y, Rich, T A, Shiotsu, Y, Franovic, A, Raymond, V M, Kurzrock, R, Lanman, R B, Lee, J, Mok, T S K

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Systemic Distribution of Steroid Sulfatase and Estrogen Sulfotransferase in Human Adult and Fetal Tissues von Miki, Yasuhiro, Nakata, Taisuke, Suzuki, Takashi, Darnel, Andrew David, Moriya, Takuya, Kaneko, Chika, Hidaka, Kumiko, Shiotsu, Yukimasa, Kusaka, Hideaki, Sasano, Hironobu

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KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules von SOGA, S, NECKERS, L. M, AKINAGA, S, SCHULTE, T. W, SHIOTSU, Y, AKASAKA, K, NARUMI, H, AGATSUMA, T, IKUINA, Y, MURAKATA, C, TAMAOKI, T

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Synthesis and Antitumor Activity of Novel O-Carbamoylmethyloxime Derivatives of Radicicol von Ikuina, Yoji, Amishiro, Nobuyoshi, Miyata, Mayumi, Narumi, Hiroaki, Ogawa, Harumi, Akiyama, Tadakazu, Shiotsu, Yukimasa, Akinaga, Shiro, Murakata, Chikara

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Expression Levels of Enzymes Related to In Situ Estrogen Synthesis and Clinicopathological Parameters in Breast Cancer Patients von Saeki, T., Suzuki, M., Nakata, T., Shiotsu, Y., Ishida, H., Akinaga, S., Aogi, K., Utsumi, T., Harada, N.

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Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients von Nakata, Taisuke, Takashima, Shigemitsu, Shiotsu, Yukimasa, Murakata, Chikara, Ishida, Hiroyuki, Akinaga, Shiro, Li, Pui-Ki, Sasano, Hironobu, Suzuki, Takashi, Saeki, Toshiaki

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Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destab... von Shiotsu, Y, Neckers, L M, Wortman, I, An, W G, Schulte, T W, Soga, S, Murakata, C, Tamaoki, T, Akinaga, S

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Optimizing the dose and schedule of KW-2449, FLT3/Aurora inhibitor, through analysis of in vivo target inhibition von Pratz, K. W., Stine, A., Karp, J., Small, D., Cortez, J., Roboz, G., Rao, N., Akinaga, S., Shiotsu, Y., Levis, M.

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Protein release behavior from carbonate apatite hydrogel von Yokogawa, Yoshiyuki, Nagata, Fukue, Kato, Katsuya, Shiotsu, Yoshikazu, Watanabe, Makoto

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Heat Shock Protein 90-antagonist Destabilizes Bcr-Abl/HSP90 Chaperone Complex von Shiotsu, Yukimasa, Soga, Shiro, Akinaga, Shiro

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