Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair von Haradhvala, Nicholas J., Polak, Paz, Stojanov, Petar, Covington, Kyle R., Shinbrot, Eve, Hess, Julian M., Rheinbay, Esther, Kim, Jaegil, Maruvka, Yosef E., Braunstein, Lior Z., Kamburov, Atanas, Hanawalt, Philip C., Wheeler, David A., Koren, Amnon, Lawrence, Michael S., Getz, Gad

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Mutational landscape of aggressive cutaneous squamous cell carcinoma von Pickering, Curtis R, Zhou, Jane H, Lee, J Jack, Drummond, Jennifer A, Peng, S Andrew, Saade, Rami E, Tsai, Kenneth Y, Curry, Jonathan L, Tetzlaff, Michael T, Lai, Stephen Y, Yu, Jun, Muzny, Donna M, Doddapaneni, Harshavardhan, Shinbrot, Eve, Covington, Kyle R, Zhang, Jianhua, Seth, Sahil, Caulin, Carlos, Clayman, Gary L, El-Naggar, Adel K, Gibbs, Richard A, Weber, Randal S, Myers, Jeffrey N, Wheeler, David A, Frederick, Mitchell J

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Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication von Shinbrot, Eve, Henninger, Erin E, Weinhold, Nils, Covington, Kyle R, Göksenin, A Yasemin, Schultz, Nikolaus, Chao, Hsu, Doddapaneni, HarshaVardhan, Muzny, Donna M, Gibbs, Richard A, Sander, Chris, Pursell, Zachary F, Wheeler, David A

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An enhanced genetic model of colorectal cancer progression history von Yang, Lixing, Wang, Su, Lee, Jake June-Koo, Lee, Semin, Lee, Eunjung, Shinbrot, Eve, Wheeler, David A, Kucherlapati, Raju, Park, Peter J

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Effects of TP53 mutational status on gene expression patterns across 10 human cancer types von Parikh, Neha, Hilsenbeck, Susan, Creighton, Chad J, Dayaram, Tajhal, Shuck, Ryan, Shinbrot, Eve, Xi, Liu, Gibbs, Richard A, Wheeler, David A, Donehower, Lawrence A

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MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes von Donehower, Lawrence A, Creighton, Chad J, Schultz, Nikolaus, Shinbrot, Eve, Chang, Kyle, Gunaratne, Preethi H, Muzny, Donna, Sander, Chris, Hamilton, Stanley R, Gibbs, Richard A, Wheeler, David

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Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma von Carlsen, Rebecca, Chuah, Eric, Clarke, Amanda, Holt, Robert A., Mayo, Michael, Schein, Jacqueline E., Thiessen, Nina, Cheung, Dorothy, Bowlby, Reanne, Shinbrot, Eve, Donehower, Lawrence A., Bowen, Jay, Helsel, Carmen, Leraas, Kristen M., Wise, Lisa, Shih, Juliann, Cherniack, Andrew D., Saksena, Gordon, Pedamallu, Chandra Sekhar, Chin, Lynda, Cho, Juok, Defreitas, Timothy, Meier, Sam, Lawrence, Michael, Hu, Jianhong, Wang, Min, Morton, Donna, Korchina, Viktoriya, Lewis, Lora, Bellair, Michelle, Lee, Sandra, Shmulevich, Ilya, Zhang, Wei, Liu, Yuexin, Iype, Lisa, Makhlouf, Hala, Kakar, Sanjay, Yeh, Matthew M., Kleiner, David E., El-Serag, Hashem B., Mishra, Lopa, Ling, Shiyun, Su, Xiaoping, Chen, Jian, Tong, Pan, Aburatani, Hiroyuki, Tatsuno, Kenji, Seiser, Eric, Gao, Jianjiong, Ochoa, Angelica, Shen, Ronglai, Arora, Arshi, Radenbaugh, Amie, Moore, David D., Totoki, Yasushi, Shibata, Tatsuhiro, Yau, Christina, Slagle, Betty L., Ojesina, Akinyemi I., Koire, Amanda, Hsu, Teng-Kuei, Felau, Ina, Wang, Zhining, Yang, Liming, Zenklusen, Jean C., Hutter, Carolyn M., Sofia, Heidi J., Chudamani, Sudha, Liu, Jia, Lolla, Laxmi, Wu, Ye, Pihl, Todd, Huang, Mei, Junior, Carlos Gilberto Carlotti, Silva, Orlando de Castro, Ahn, Keun Soo, Moser, Catherine D., Giordano, Thomas J., Crain, Daniel, Curley, Erin, Morris, Scott, Paulauskis, Joseph, Shelton, Candace, Shelton, Troy, Roberts, Lewis R., Hagedorn, Curt H., O'Brien, Daniel R., Perou, Charles M., Skelly, Tara, Veluvolu, Umadevi, Balu, Saianand, Hoyle, Alan P., Jefferys, Stuart R., Meng, Shaowu, Mose, Lisle E., Simons, Janae V., Hoadley, Katherine A., Shen, Hui, Berrios, Mario, Laird, Peter W.

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Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma von Linehan, W Marston, Spellman, Paul T, Ricketts, Christopher J, Creighton, Chad J, Fei, Suzanne S, Davis, Caleb, Wheeler, David A, Murray, Bradley A, Schmidt, Laura, Vocke, Cathy D, Peto, Myron, Al Mamun, Abu Amar M, Shinbrot, Eve, Sethi, Anurag, Brooks, Samira, Rathmell, W Kimryn, Brooks, Angela N, Hoadley, Katherine A, Robertson, A Gordon, Brooks, Denise, Bowlby, Reanne, Sadeghi, Sara, Shen, Hui, Weisenberger, Daniel J, Bootwalla, Moiz, Baylin, Stephen B, Laird, Peter W, Cherniack, Andrew D, Saksena, Gordon, Haake, Scott, Li, Jun, Liang, Han, Lu, Yiling, Mills, Gordon B, Akbani, Rehan, Leiserson, Mark D M, Raphael, Benjamin J, Anur, Pavana, Bottaro, Donald, Albiges, Laurence, Barnabas, Nandita, Choueiri, Toni K, Czerniak, Bogdan, Godwin, Andrew K, Hakimi, A Ari, Ho, Thai H, Hsieh, James, Ittmann, Michael, Kim, William Y, Krishnan, Bhavani, Merino, Maria J, Mills Shaw, Kenna R, Reuter, Victor E, Reznik, Ed, Shelley, Carl S, Shuch, Brian, Signoretti, Sabina, Srinivasan, Ramaprasad, Tamboli, Pheroze, Thomas, George, Tickoo, Satish, Burnett, Kenneth, Crain, Daniel, Gardner, Johanna, Lau, Kevin, Mallery, David, Morris, Scott, Paulauskis, Joseph D, Penny, Robert J, Shelton, Candace, Shelton, W Troy, Sherman, Mark, Thompson, Eric, Yena, Peggy, Avedon, Melissa T, Bowen, Jay, Gastier-Foster, Julie M, Gerken, Mark, Leraas, Kristen M, Lichtenberg, Tara M, Ramirez, Nilsa C, Santos, Tracie, Wise, Lisa, Zmuda, Erik, Demchok, John A, Felau, Ina, Hutter, Carolyn M, Sheth, Margi, Sofia, Heidi J, Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Zenklusen, Jean C, Zhang, Jiashan, Ayala, Brenda, Baboud, Julien, Chudamani, Sudha, Liu, Jia, Lolla, Laxmi, Naresh, Rashi

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Abstract 2474: Automated somatic variant classifier to reduce false positives identified by tumor normal variant callers von Harley, Alena S., Lau, Corine K., Shinbrot, Eve

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Comprehensive molecular characterization of human colon and rectal cancer von Muzny, Donna M, Bainbridge, Matthew N, Chang, Kyle, Dinh, Huyen H, Drummond, Jennifer A, Fowler, Gerald, Kovar, Christie L

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Trans-ancestry mutational landscape of hepatocellular carcinoma genomes von Totoki, Yasushi, Tatsuno, Kenji, Covington, Kyle R, Ueda, Hiroki, Creighton, Chad J, Kato, Mamoru, Tsuji, Shingo, Donehower, Lawrence A, Slagle, Betty L, Nakamura, Hiromi, Yamamoto, Shogo, Shinbrot, Eve, Hama, Natsuko, Lehmkuhl, Megan, Hosoda, Fumie, Arai, Yasuhito, Walker, Kim, Dahdouli, Mahmoud, Gotoh, Kengo, Nagae, Genta, Gingras, Marie-Claude, Muzny, Donna M, Ojima, Hidenori, Shimada, Kazuaki, Midorikawa, Yutaka, Goss, John A, Cotton, Ronald, Hayashi, Akimasa, Shibahara, Junji, Ishikawa, Shumpei, Guiteau, Jacfranz, Tanaka, Mariko, Urushidate, Tomoko, Ohashi, Shoko, Okada, Naoko, Doddapaneni, Harsha, Wang, Min, Zhu, Yiming, Dinh, Huyen, Okusaka, Takuji, Kokudo, Norihiro, Kosuge, Tomoo, Takayama, Tadatoshi, Fukayama, Masashi, Gibbs, Richard A, Wheeler, David A, Aburatani, Hiroyuki, Shibata, Tatsuhiro

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Impact of COVID-19 on delay in cancer diagnostic testing von Juncker-Jensen, Anna, Lau, Corine K., Shah, Manan, Weiss, Lawrence Martin, Shinbrot, Eve

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Genetic Mechanisms of Immune Evasion in Colorectal Cancer von Grasso, Catherine S, Giannakis, Marios, Wells, Daniel K, Hamada, Tsuyoshi, Mu, Xinmeng Jasmine, Quist, Michael, Nowak, Jonathan A, Nishihara, Reiko, Qian, Zhi Rong, Inamura, Kentaro, Morikawa, Teppei, Nosho, Katsuhiko, Abril-Rodriguez, Gabriel, Connolly, Charles, Escuin-Ordinas, Helena, Geybels, Milan S, Grady, William M, Hsu, Li, Hu-Lieskovan, Siwen, Huyghe, Jeroen R, Kim, Yeon Joo, Krystofinski, Paige, Leiserson, Mark D M, Montoya, Dennis J, Nadel, Brian B, Pellegrini, Matteo, Pritchard, Colin C, Puig-Saus, Cristina, Quist, Elleanor H, Raphael, Ben J, Salipante, Stephen J, Shin, Daniel Sanghoon, Shinbrot, Eve, Shirts, Brian, Shukla, Sachet, Stanford, Janet L, Sun, Wei, Tsoi, Jennifer, Upfill-Brown, Alexander, Wheeler, David A, Wu, Catherine J, Yu, Ming, Zaidi, Syed H, Zaretsky, Jesse M, Gabriel, Stacey B, Lander, Eric S, Garraway, Levi A, Hudson, Thomas J, Fuchs, Charles S, Ribas, Antoni, Ogino, Shuji, Peters, Ulrike

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Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma von Chen, Fengju, Zhang, Yiqun, Şenbabaoğlu, Yasin, Ciriello, Giovanni, Yang, Lixing, Reznik, Ed, Shuch, Brian, Micevic, Goran, De Velasco, Guillermo, Shinbrot, Eve, Noble, Michael S., Lu, Yiling, Covington, Kyle R., Xi, Liu, Drummond, Jennifer A., Muzny, Donna, Kang, Hyojin, Lee, Junehawk, Tamboli, Pheroze, Reuter, Victor, Shelley, Carl Simon, Kaipparettu, Benny A., Bottaro, Donald P., Godwin, Andrew K., Gibbs, Richard A., Getz, Gad, Kucherlapati, Raju, Park, Peter J., Sander, Chris, Henske, Elizabeth P., Zhou, Jane H., Kwiatkowski, David J., Ho, Thai H., Choueiri, Toni K., Hsieh, James J., Akbani, Rehan, Mills, Gordon B., Hakimi, A. Ari, Wheeler, David A., Creighton, Chad J.

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Abstract 2208: A comprehensive genomic profiling approach to detect functional translocations and genomic alterations in a single tube workflow von Wong, Cynthie, Thomas, Brad, Mou, Yanglong, Magnan, Christophe, Jung, Segun, Gyuris, Tibor, Alarcon, Francys, Shinbrot, Eve, Ye, Fei, Bender, Ryan, Agersborg, Sally, Weiss, Lawrence, Funari, Vincent

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Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival von Zaidi, Syed H., Harrison, Tabitha A., Phipps, Amanda I., Steinfelder, Robert, Trinh, Quang M., Qu, Conghui, Banbury, Barbara L., Georgeson, Peter, Grasso, Catherine S., Giannakis, Marios, Adams, Jeremy B., Alwers, Elizabeth, Amitay, Efrat L., Barfield, Richard T., Berndt, Sonja I., Borozan, Ivan, Brenner, Hermann, Brezina, Stefanie, Buchanan, Daniel D., Cao, Yin, Chan, Andrew T., Chang-Claude, Jenny, Connolly, Charles M., Drew, David A., Farris, Alton Brad, Figueiredo, Jane C., French, Amy J., Fuchs, Charles S., Garraway, Levi A., Gruber, Steve, Guinter, Mark A., Hamilton, Stanley R., Harlid, Sophia, Heisler, Lawrence E., Hidaka, Akihisa, Hopper, John L., Huang, Wen-Yi, Huyghe, Jeroen R., Jenkins, Mark A., Krzyzanowski, Paul M., Lemire, Mathieu, Lin, Yi, Luo, Xuemei, Mardis, Elaine R., McPherson, John D., Miller, Jessica K., Moreno, Victor, Mu, Xinmeng Jasmine, Nishihara, Reiko, Papadopoulos, Nickolas, Pasternack, Danielle, Quist, Michael J., Rafikova, Adilya, Reid, Emma E. G., Shinbrot, Eve, Shirts, Brian H., Stein, Lincoln D., Teney, Cherie D., Timms, Lee, Um, Caroline Y., Van Guelpen, Bethany, Van Tassel, Megan, Wang, Xiaolong, Wheeler, David A., Yung, Christina K., Hsu, Li, Ogino, Shuji, Gsur, Andrea, Newcomb, Polly A., Gallinger, Steven, Hoffmeister, Michael, Campbell, Peter T., Thibodeau, Stephen N., Sun, Wei, Hudson, Thomas J., Peters, Ulrike

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A Novel Multimodal Next Generation Sequencing Assay with Total Nucleic Acid Input to Provide Comprehensive Genomic Profiling for Hematologic Malignancies von Yu, Yongxin, Alarcon, Francys, Mou, Yanglong, Jung, Segun C, Nam, Hyunjun, Thomas, Brad, Keeler, Lauryn, Shinbrot, Eve, Magnan, Christophe, Weiss, Tessa, Bender, Ryan, Jiang, Shi-Ping, Agersborg, Sally, Weiss, Lawrence, Ye, Fei, Funari, Vincent

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Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma von Linehan, W. Marston, Spellman, Paul T., Ricketts, Christopher J., Creighton, Chad J., Fei, Suzanne S., Davis, Caleb, Wheeler, David A., Murray, Bradley A., Schmidt, Laura, Vocke, Cathy D., Peto, Myron, Al Mamun, Abu Amar M., Shinbrot, Eve, Sethi, Anurag, Brooks, Samira, Rathmell, W. Kimryn, Brooks, Angela N., Hoadley, Katherine A., Robertson, A. Gordon, Brooks, Denise, Bowlby, Reanne, Sadeghi, Sara, Shen, Hui, Weisenberger, Daniel J., Bootwalla, Moiz, Baylin, Stephen B., Laird, Peter W., Cherniack, Andrew D., Saksena, Gordon, Haake, Scott, Li, Jun, Liang, Han, Lu, Yiling, Mills, Gordon B., Akbani, Rehan, Leiserson, Mark D.M., Raphael, Benjamin J., Anur, Pavana, Bottaro, Donald, Albiges, Laurence, Barnabas, Nandita, Choueiri, Toni K., Czerniak, Bogdan, Godwin, Andrew K., Hakimi, A. Ari, Ho, Thai, Hsieh, James, Ittmann, Michael, Kim, William Y., Krishnan, Bhavani, Merino, Maria J., Mills Shaw, Kenna R., Reuter, Victor E., Reznik, Ed, Shelley, Carl Simon, Shuch, Brian, Signoretti, Sabina, Srinivasan, Ramaprasad, Tamboli, Pheroze, Thomas, George, Tickoo, Satish, Burnett, Kenneth, Crain, Daniel, Gardner, Johanna, Lau, Kevin, Mallery, David, Morris, Scott, Paulauskis, Joseph D., Penny, Robert J., Shelton, Candace, Shelton, W. Troy, Sherman, Mark, Thompson, Eric, Yena, Peggy, Avedon, Melissa T., Bowen, Jay, Gastier-Foster, Julie M., Gerken, Mark, Leraas, Kristen M., Lichtenberg, Tara M., Ramirez, Nilsa C., Santos, Tracie, Wise, Lisa, Zmuda, Erik, Demchok, John A., Felau, Ina, Hutter, Carolyn M., Sheth, Margi, Sofia, Heidi J., Tarnuzzer, Roy, Wang, Zhining, Yang, Liming, Zenklusen, Jean C., Zhang, Jiashan (Julia), Ayala, Brenda, Baboud, Julien, Chudamani, Sudha, Liu, Jia, Lolla, Laxmi, Naresh, Rashi

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Abstract 3420: Integrative tumor profiling beyond panel sequencing von Lau, Corine K., Harley, Alena S., Choppa, Paul, Cooc, Janine, Kyshtoobayeva, Ainura, Jun, Natalia, Dayrit, Mark, Delport, Wayne, Saldivar, Mark, Jun, Yop, Trivedi, Raaj, Gylfe, Alexandra E., Lacey, Travis R., Cohen, Ezra, Bloom, Kenneth, Shinbrot, Eve

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Abstract B011: Immunoediting in untreated mismatch repair deficient colorectal cancer von Grasso, Catherine, Giannakis, Marios, Wells, Daniel, Wheeler, David, Shinbrot, Eve, Zaidi, Syed, Huyghe, Jeroen, Geybels, Milan, Salipante, Stephen, Abril-Rodriguez, Gabriel, Escuin-Ordinas, Helena, Puig-Saus, Cristina, Shin, Daniel Sanghoon, Ogino, Shuji, Ribas, Antoni, Peters, Ulrike

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